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ANTIOXIDANT POTENTIAL OF CINNAMALDEHYDE; AN INVITRO STUDY

Journal Name:

  • The International Journal of Pharmaceutical Research and Bio-Science

Publication Year:

  • 2013

Key Words:

Author Name
Abstract (2. Language): 
Antioxidants are the agents that are capable of effectively neutralizing the deleterious effects of free radicals. Therefore, the need for the search of antioxidants from natural origin has been greatly felt in the recent years. Cinnamaldehyde (CA) exert antimicrobial, anti tumor, anti inflammatory, anti diabetic effects as well as anti gastric properties. CA is potential against different free radicals which result in oxidative damage leading to various diseases. Current work was carried to evaluate the radical scavenging activities using different invitro models like DPPH, Superoxide, Nitric Oxide, H2O2 scavenging activity and Reducing power. Total antioxidant capacity expressed as equivalents of 160μg of Vitamin E / g of CA. CA has shown potent antioxidant activity in these methods with IC50 values of 377, 391, 437, 390 and 462μg/ml, respectively. The antioxidant activity of CA was compared with the standards like Ascorbic acid (AA) and Butylated hydroxy toluene (BHT). The results obtained in the present study indicate that the CA can act as a potential source of antioxidant scavenging free radicals and preventing oxidative stress leading to various diseases.
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REFERENCES

References: 

1. Aruoma O I: Free radicals, oxidative
stress, and antioxidants in human health
and disease. J Am Oil Chem Soc 1998; 75:
199.
2. Dehpour AA, Ebrahimzadeh MA, Nabavi
SF and Nabavi SM: Antioxidant activity of
methanol extract of Ferula assafoetida and
its essential oil composition. Grasas Aceites
2009; 60(4): 405-412.
3. Devasagayam TPA, Tilak JC, Boloor KK et
al. Review: Free radical and antioxidants in
human health. Curr Stat Fut Pros JAPI 2004;
53:794-804.
4. Green LC, Wagner DA, Glogowski J,
Skipper PL, Wishnok JS and Tannonbaum
SR: Analysis of nitrate and in biological
fluids. Analytical Biochemistry 1982: 126-
131.
5. Halliwell B and Gutteridge JM and
Aruoma OI: The deoxyribose method and
simple test tube assay for determination of
rate constants for teactions of hydroxyl
radicals. Anal. Biochem 1987; 165: 215-219.
6. Halliwell B: Free radicals, reactive
oxygen species and human disease: a
critical evaluation with special reference to
atherosclerosis. Br. J. Exp. Pathol 1989; 70:
737‐757.
7. Hyland K, Voisin E, Bonoun H and Auclair
C: Superoxide dismutase assay using
alkaline dimethyl sulfoxide as superoxide
anion genating system. Anal. Biochem 1983;
135: 280-287.
8. Ilhami GI, Haci AA, Mehmet C:
Determination of in Vitro Antioxidant and
Radical Scavenging Activities of Propofol.
Chem. Pharm. Bull 2005; 53: 281‐285.
9. Karadag A, Ozcelik B, Saner S: Review of
Methods to Determine Antioxidant
Capacities. Food Anal. Methods 2009; 2:
41‐60.
10. Koleva II, Van Beck TA, Linson, De Groot
A and Evstatieva LN: Screening of plant
extracts for antioxidant activity. A
comparative study on three testing method.
Phytochemical Analysis 2002; 2: 125-134.
11. Lata H, Ahuja GK: Role of free radicals in
health and disease. Ind. J. Physiol. Allied Sci
2003; 57: 124‐132.
12. Nabavi SM, Ebrahimzadeh MA, Nabavi
SF, Fazelian M and Eslami B: In vitro
antioxidant and free radical scavenging
activity of Diospyros lotus and Pyrus
boissieriana growing in Iran.
Pharmacognosy Magazine 2009; 4(18): 123-
127.
13. Nabavi SM, Ebrahimzadeh MA, Nabavi
SF, Hamidimia A and Bekhradnia AR:
Determination of antioxidant activity,
phenol and flavonoids content of Parrotia
persica Mey. Pharmacologyonline 2009; 32:
560- 567.
Research Article CODEN: IJPRNK ISSN: 2277-8713
K Vijayalakshmi, IJPRBS, 2013; Volume 2(5):270-278 IJPRBS
Available Online at www.ijprbs.com
278
14. Oyaizu M: Studies of products browning
reaction; Antioxidant activity of products of
browning reaction prepared from
glucosamine. Jap. J. Nut 1986; 44: 307-315.
15. Porto C D, Calligaris S, Cellotti E & Nicoli
M C: Antiradical properties of commercial
cognacs assessed by the DPPH test, J Agric
Food Chem 2000; 48: 4241.
16. Prieto P, Pineda M, Aguilar M:
Spectorophotometric quantification of
antioxidant capacity through the formation
of phosphomolybdenum complex specific
application to the determination of Vitamin
E. Anal biochem 1999; 69: 337-41.
17. Prior RL, Wu X, Schaich K: Standardized
methods for the determination of
antioxidant capacity and phenolics in foods
and dietary supplements. J. Agric. Food
Chem 2005; 53: 4290‐ 4302.
18. ReddyAM, Seo JH, Ryu SY, Kim YS, Min
KR: Cinnamaldehyde and 3-
methoxycinnamaldehyde as Nf- KappaB
inhibitors from Cinnamomum cassia. Plant
Med 2004; 70: 823-827.
19. Ruch RT, Cheng SJ. and Klawnig E:
Prevention of cytotoxicity and inhibition of
intercellular communication by antioxidant
catechins isolated from Chineese green tea.
Carcinogenesis 1989; 10: 1003-1009.
20. Sato M, Ramarathnam N, Suzuki Y,
Ohkubo T, Takeuchi M and Ochi H: Varietal
differences in the phenolic content and
superoxide radical scavenging potential of
wines from different sources. J. Agri. Food
Chem 1996; 44: 37-41.
21. Silva B, Ferreres F, Malva J, Dias A:
Phytochemical and antioxidant
characterization of Hypericum perforatum
alcoholic extracts. Food Chem 2005; 90:
157-167.
22. Suzi S. Atalla and Aida El- Makawy:
Could Cinnamaldehyde be harmful?
Histological, Cytogenetical and biochemical
studies on its effect on some organs of
mice. The Egyptian journal of histology
2007; 30(2): 47-464.
23. Wickens A P: Aging and the free radical
theory. Respir Physiol 2001; 128: 379.

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