You are here

Home » Content

ANTI-INFLAMMATORY AND ANTI-PYRETIC ACTIVITY OF ETHANOLIC EXTRACT OF INDIGOFERA ASPALATHOIDES (VAHL EX DC) LEAVES.

Journal Name:

  • The International Journal of Pharmaceutical Research and Bio-Science

Publication Year:

  • 2013

Key Words:

Author Name
Abstract (2. Language): 
Indigofera aspalathoides has been used traditionally in the siddha medicine to treat elephantiasis, skin disorder, leprosy and cancer. The in vitro anti-inflammatory effect of the ethanolic extract of Indigofera aspalathoides leaves (EEIa) was subjected to HRBC membrane stabilization. In vivo anti-inflammatory activity was assessed by Carrageenan induced paw edema and in vivo anti pyretic activity was investigated by yeast induced pyrexia using Indomethacin and paracetamol as standards respectively. The effect of ethanolic leaf extract on HRBC membrane stabilization showed positive correlation exists between the concentration and the activity i.e. activity is directly proportional to concentration of the sample. EEIa at test doses of 100 and 150 mg/kg clearly demonstrated anti– inflammatory effects by reducing paw edema induced by carrageenan in a dose dependent manner in all the treated groups. Pyrexia was also found to be decreased in treated groups on dose dependent manner. The present study contributes towards validation of the traditional use of ethanolic extract of Indigofera aspalathoides leaves for the treatment of inflammatory and pyrexia related disorders.
Bookmark/Search this post with
FULL TEXT (PDF): 
PDF icon arastirmax-anti-inflammatory-and-anti-pyretic-activity-ethanolic-extract-indigofera-aspalathoides-vahl-ex-dc-leaves.pdf
  • 5
391
403
  • English

REFERENCES

References: 

1. Molinski TF: Development in marine
natural products receptor specific bioactive
compounds. J Nat Prod 1993; 56:1-8.
2. Grabley S and Thiericke R: Bioactive
agents from natural resources-Trends in
discovery and application. Adv Bio chem
eng Bio technol 1999; 64:101-54.
3. Coussens LM and Werb Z: Inflammation
and cancer. Nature 2002; 420: 860-7.
4. Balkwill F and Mantovania: Cancer and
inflammations-Implication for
pharmacology and therapeutics. Clin
pharmacol ther 2010; 87:401-6.
5. Mantovani A ,Garlanda C and Allavena P :
Molecular pathways and targets in cancer
related inflammation. Am Med 2010;
42:161-70.
6. Grivennikov SI and Karin M:
Inflammation and oncogenesis; A Vicious
Connection. Curr opin Genet Dev 2010;
20:65-71.
7. Chattopadhyay D, Arunachalam G and
Ghosh et al: Antipyretic activity of Alstonia
macrophylla wall DC; An ethno medicine of
Andaman Islands. J. Pharm Pharmaceutical
Sci 2005; 8:558-564.
8. Spacer CB and Breder CD: The Neurologic
basis of fever. N Eng J Med1994; 330: 1880-
1886.
Research Article CODEN: IJPRNK ISSN: 2277-8713
Jothip Priya Ganapathy, IJPRBS, 2013; Volume 2(5):391-403 IJPRBS
Available Online at www.ijprbs.com
402
9. Veugelers PJ, Kaldor JM and Strathdae
SA et al: Incidence and Prognostic
significance of symptomatic primary human
immunodeficiency virus type 1 infection in
men. J. Infect. Dis 1997; 176:112-117.
10. Kirtikar KR and Basu D: Glossary of
Indian Medicinal plants 1975 Vol I, m/s
Periodical Experts, New Delhi: 338.
11. The Wealth of India: A Dictionary of
Indian Raw Materials and industrial
Products, Raw Materials. Vol V, H-K,
Publication and Information Direction,
Council of Scientific and Industrial Research
New Delhi, India 1959:176.
12. Nandakarni AK :.Indian Materia Medica.
Popular prakashan1976:112.
13. Gandhidasan R, Thamaraichelvam A and
Baburaj S: Anti inflammatory action of
Lannca coromandelica HRBC membrane
stabilization.Fitotherpia1991;62:82-83.
14. Winter C, Risley EA and Nuss GW:
Carrageenan-induced edema in hind paws
of the rat as an assay for anti-inflammatory
drugs. Proc Soc Exp Biol Med 1962;
111:544–547.
15. Loux JJ De Palma PD and Yankel SL:
1972. Antipyretic testing of aspirin in rats.
Toxicol Appl Pharmacol 1972; 22 (4): 672-
675.
16. Chou CT: The anti-inflammatory effect
of Tripterygium wilfordii Hook F on
adjuvant-induced paw edema in rats and
inflammatory mediators release. Phytother
Res 1997; 11:152-154.
17. Basu A and Nag Chaudhuri AK:
Preliminary studies on the antiinflammatory
and analgesic activities of
Calotropis procera root extract. Journal of
Ethno pharmacology 1991; 31: 319–324.
18. Santos AR, Vedana EM and De Freitas
GA: Anti-nociceptive effect of meloxicam in
neurogenic and inflammatory nociceptive
models in rats. Inflammation
Research1998b; 47: 302–307.
19. Zheng CJ, Tang WZ, Huang BK, Han T,
Zhang QY, Zhang and Qin LP: Bioactivityguided
fractionation for analgesic
properties and constituents of Vitex
negundo L. seeds. Phytomedicine 2009; 16:
560–567.
20. Ribeiro RA, Vale ML, Thomazzi SM ,
Paschoalato ABP, Poole S, Ferreira SH and
Cunha FQ: Involvement of resident
macrophages and mast cells in the writhing
nociceptive response induced by zymosan
and acetic acid in rats. European Journal of
Pharmacology 2000; 387:111–118.
21. Antonisamy P and Ignacimuthu S:
Immunomodulatory, analgesic and
antipyretic effects of violacein isolated from
Chromo bacterium violaceum.
Phytomedicine 2010; 17: 300–304.
22. Panthong A, Supraditaporn W,
Kanjanapothi D , Taesotikul T and Reutrakul
V:Analgesic,anti-Inflammatory and
venotonic effects of Cissus quadrangularis
Linn. Journal of Ethno pharmacology 2007;
110: 264–270.
Research Article CODEN: IJPRNK ISSN: 2277-8713
Jothip Priya Ganapathy, IJPRBS, 2013; Volume 2(5):391-403 IJPRBS
Available Online at www.ijprbs.com
403
23. Guyton AC, Hall JE: Text book of medical
physiology. 9th ed. Philadelphia: W.B.
Saunders Company 1998: 920-922.
24. Harborne JB: Phytochemical methods
11th Edn in Chapman &Hall New York, 1984.

Thank you for copying data from http://www.arastirmax.com