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MİNÖR GRUP ERİTROSİT ANTİKORLARINA BAĞLI YENİDOĞAN HEMOLİTİK HASTALIĞI

Journal Name:

  • İstanbul Tıp Fakültesi Dergisi

Publication Year:

  • 1998

Key Words:

Keywords (Original Language):

Author Name
Abstract (2. Language): 
Hemolytic disease of tlıe nevvborn due to minör group antibodies. In this study, our purpose was to understand the importance of minör group erythrocyte antibody in newborn hemolytic disease in patients who hadn't incompatibility of ABO and Rh antigens. 33 nevvborns who had hyperbilirubinemia were iııcluded in this study. The antiglobulin (Direct Coombs) test was done in babies and maternal Coombs titration (Indirect Coombs) test was done in babies and maternal Coombs titration (Indirect Coombs) test was done in their mothers. A patient whose Direct Coombs test was positive undervvent exchange transfusion 27 hours later. We found E antigen in this baby and anti-E in his mother. In three babies which had Direct Coombs test negative, Indirect Coombs test was positive. In two of them, anti-Lub and anti-Jkb were found. As a result, vve consider that, it is necesary to do antenatal screening in ali pregnant women inorder to discover newborn hemolytic disease as soon as possible.
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Abstract (Original Language): 
Çalışmamızda ABO ve Rh uygunsuzluğu saplanmayan, ancak hiperbilirubinemi nedeniyle tedaviye alınan yenidoğanlarda minör grup antikorlarının varlığını saptayabilmek ve bunların yenidoğan hemolitik hastalığındaki önemini belirlemek amaçlandı. Çalışmamıza yenidoğan servisinde hiperbilirubinemi nedeniyle yatırılan 33 bebeği aldık. Bebeklerde direkt Coombs testi, annelerinde ise indirekt Coombs testi yapıldı. Direkt ve indirekt Coombs pozitif olan ve 27. saatinde kan değişimi yapılan bir bebekte E antijeni, annede ise anti-e saptadık. Direkt Coombs negatif olan bebeklerin üçünde annelerde indirekt Coombs pozitif idi. Bunların ikisinde anti-Lub ve anti-Jkb saptandı. Sonuç olarak sorun olmaya devam eden yeni doğan hemolitik hastalığının erken tanısı için tüm gebelerde antenatal taramanın gerekli olduğuna karar verildi.
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  • 4
425-428
  • Turkish

REFERENCES

References: 

KAYNAKLAR
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