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OSTEOPOROZDA AİLE ÖYKÜSÜ VE CİNSİYET FAKTÖRÜNÜN İNCELENMESİ

Journal Name:

  • İstanbul Tıp Fakültesi Dergisi

Publication Year:

  • 2000

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Family history and gender effect in osteoporosis. There is a lot of epidemi ol ogical evidence supporting the role for genetic İnfluences on the bone density and osteoporotic fraetures. İn this study, the family history of osteoporosis and its interaction with enviromental conditions have been evaluated. A qucstionnaire form was prepared and filled out for each 92-male and 298-female research subject after his or her Dual Energy X-ray Absorbsiometry (DEXA) had been performed. The anthropometric data, education level, menopausc age, skin and hair color, diabetic habit, and the resideney area of the subjects were recorded. İn addition, the inforınation about the previo-us fraetures and osteoporosis İn their families were obtained. In this study, the subjects belonging to osteoporotic and control groups differed from each ot-her with respect to some characteristics such as age, body mass index, education, menopouse age and resideney. We have found that previous fraetures do not play an important role in the determination of osteoporosis. The inquisition of osteoporosis or relevant factors İn a family has had no predietive power on the osteoporosis in female subjects wheıeas osteoporosis has been more frequently diagnosed in male subjects having a positive fraeture history in their fa-milİcs. As a conelusion, it İs crucial for the predietion of osteoporosis that males be questioned in terms of the family history in clinical praetice in addition to the enviromental conditions with which they are faced. Hcncc, for those patients who are subject to furlher complicated exposi-tions will be seleeted based on more accurate criteria.
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Abstract (Original Language): 
Kemik mineral yoğuniuğu (KMY) ve osteoporotik kırıklar üzerinde genetik faktörlerin rolünü destekleyen pek çok epidemiyolojik kanıt bulunmaktadır. Bu çalışmada osteoporozda aile hikayesi ve bunun çevresel faktörlerle etkileşimi araştırılmıştır. Bu amaçla Dual enerji X-ray absorbsİometre (DEXA) ölçümleri yapılmış 92 erkek ve 298 kadın için bir sorgulama formu doldurulmuştur. Antropometrik veriler, eğitim düzeyi, menopoz yaşı, cilt ve saç rengi, diyel ve yerleşim yeri kaydedilmiştir. Ayrıca önceki kırıklar ve ailede osteoporoz hikayesi ile ilgili bilgi edinilmiştir. Çalışmamızda osteoporozu olanlar ile kontrol grubunda yer alan olgular yaş, vücut kitle indeksi, eğitim durumları, menopoz yaşı ve yerleşim yerleri gibi özellikleri yönünden farklılık göstermekteydiler. Önceki geçirilen kırıkların osteoporozu belirlemede önemli olmadığı bulunmuştur. Ailede osteoporoz veya ilişkili faktörlerin sorgulanması, kadın olgularda osteoporozu olanları tahmin etmede önemli bulunmamış tır. Ailelerinde kırık öyküsü olan erkeklerde ise osteoporoz daha sık olarak gözlenmiştir. Sonuç olarak osteoporozun kestİrimi için klinik pratikte, çevresel faktörlerin yanısıra aile öy-küsüün sorgulanması erkek bireyler için önem taşımaktadır. Böylece ileri tetkik uygulanacak olan hastalar daha doğrulukla belirlenecektir.
FULL TEXT (PDF): 
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  • 1
68-75
  • Turkish

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