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BÜYÜME HORMONU EKSİKLİĞİNDE MANYETİK REZONANS GÖRÜNTÜLEME BULGULARININ DEĞERLENDİRİLMESİ

Journal Name:

  • İstanbul Tıp Fakültesi Dergisi

Publication Year:

  • 2000

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
SUMMARY Magnetic resonance imaging (MRI) findings in patients with idiopatine growîh hormone deficieney. This study was condueted to evaiuate the MRI findings in patients with idiopatine grovvth hormone (GH)deficİency and evaiuate the correlations between abnormal findings on MRI with clinical and hormonal parameters. AuxoIogical and clinical parameters at presentation were recorded in 58 patients (33 M, 25F) wİth GH deficieney in whonı the diagnosis was based on peak GH levels <10 ng/ml in at least two provocative tests. The patients were divided into two groups based on the pituitary height measured on MRI: Group 1 with a pituitary height below -2SD of the mean lor normal children and group 2 with a pituitary height in normal ranges. The chronological ages of the two groups were comparable. Group 1 had a significantly lower height SDS [-4.0(1.6) ] than group2 [-2.9(1.5) ] and a lower peak GH response [3.1(2.0 ) and (4.9(1.9) ] (p<0.001). Other anterior pituitary hormones were deficient in 60 % of group 1 compared to 28.6% of group 2 (p<0.001). There were no differences widı respect to the mode of delivery between the twö groups.There was a positİve significant correlatioıı between the pituitary height on MRI and peak GH levels on stimulatİon tests (r:0.85, p<0.001). It was coneluded that MRI studies give a considerable information about the etİology and severity of idiopatine GH deficieney. As the pituitary height decreases, GH defieney becomes more severe and is more often accompanied by other pituitary hormone deficiencies. MRI findings seem also to confirm the results obfaİned İn GH stimulation tests.
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Abstract (Original Language): 
Bu çalışmanın amacı İdyopatik büyüme hormonu eksikliği (BHE) olan hastaların manyetik rezonans görüntüleme (MRG) bulgularını değerlendirmek ve anormal MRG bulguları ile klinik ve hormonal parametreler arasındaki korelasyonu karşılaştırmaktır. En az İki uyarı testine doruk BH yanıtının 10 ng/mi'nin allında olması ile BHE tanısı konulan 58 hasta (33E, 25K) başlangıçtaki klinik ve oksolojik parametreleri ile değerlendirildi. Hipofiz yüksekliği kronolojik yaşa göre normalin -2SD'nın altında kalanlar (grupl) ve normal olanlar (grup2) olarak İki gruba ayrıldı. İki grubun tanı yaşları arasında fark olmadığı görüldü. Grupl'in boy SDS değerleri [-4.0(1.6) ] grup 2'ye [-2.9(1.5) ] göre anlamlı derecede düşük bulundu (p<0.001). BH doruk değerlerine bakıldığında grupl'in doruk BH yanıtı [ 3.1 (2.0) ng/ml ] grup2'ye [4.9(1.9) ng/ml ] göre düşük bulundu (p<0,001). Hipofiz yüksekliği -2 SD'nin altında bulunan vakalarda çoğul hormon eksikliği oranının yüksek olduğu görüldü (%66, %28.6) (p<0.001). Vakaların doğum şekillerine bakıldığında İki grup arasında fark görülmedi. MRG'de hipofiz yüksekliği ortalamanın -2'SD'nin altında kalan vakalarda (grupl) hipofiz yükseldiği ile BH doruk değeri arasında pozitif korelasyon bulundu (n 0.85, p<0.001). Sonuç olarak MRG incelemesinin BHE'de tanıya yardımcı bir unsur olduğu ve sığ hipofiz saptanan vakaların boylarının daha kısa, BH düzeylerinin daha düşük ve sıklıkla çoğul hormon eksildiğinin eşlik ettiği görüldü
FULL TEXT (PDF): 
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  • 4
387-391
  • Turkish

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