You are here

Home » Content

SIÇANLARDA ABDOMİNAL ADA FLEBİ MODELİNDE VENÖZ OKLÜZYON SÜRESİ İLE REPERFÜZYON HASARININ İLİŞKİSİ

Journal Name:

  • İstanbul Tıp Fakültesi Dergisi

Publication Year:

  • 2000

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
The relation between venous ocelusion peri od and reperfusion injury in abdominal flep of rats. Skin flep failure is a commonly eııcountered problem in venous insufficiency. A standart model of reperfusion injury due (o venous stasıs in the epigastrik artery and vein based abdominal flep of rats was created in order to evaluate treatment choices of venous stasıs. Fi-ve groups each consisting of eight animals were performed. A 5x3 cm3 neurovascular skin is-land fiap based on the inferior epigastrik artery and vein was raised and vein was clamped. Af-ter two hours in fırst group, five hours in second group, seven hours in third group, nine hours in fourth group and ten hours in fifth group elamps were removed and mean survival rate of flaps were %100, 100%, 82%, 20%, and 3% respeetively. As wide sprcad reperfusion injury and "reflow" was possible
Bookmark/Search this post with
Abstract (Original Language): 
Veııöz yetmezlik sonucu aksiyal devi fleplerinde doku kaybı sık karşılaşılan bir problemdir. Çalışmamızda, venöz staz sonrası tedavi seçeneklerini değerlendirebilmek amacıyla,sıçanlarda epİgasrik arter ve ven pcdiküllü nörovasküler abdominal ada flebinde standart bir venöz staz hasan modeli oluşturulmuştur. 5 ayrı grup sıçannın (n=8) 5x3 cm3 abdominal ada flebinde epi-gastrik ven 2, 5, 7, 9 ve 10 saat süreyle klemplenerek venöz staz sağlanmıştır. Bu süreler sonunda reperfüze edilen fleplerde sırasıyla %100, %100, %82, %20 vc %3'luk ortalama canlı flep alanlarına ulaşılmıştır. Hem yaygın doku hasarı oluşması, hemde 'reflow' gözlenmesi nedeniyle dokuz saatlik venöz staz süresi ideal venöz staz süresi olarak değerlendirilmiştir
FULL TEXT (PDF): 
PDF icon arastirmax-sicanlarda-abdominal-ada-flebi-modelinde-venoz-okluzyon-suresi-ile-reperfuzyon-hasarinin-iliskisi.pdf
  • 4
371-374
  • Turkish

REFERENCES

References: 

1. Kleinert HE, Kasdan ML: Small vessel anastomosis for salvage of scverely injured upper extrcmity. J Bone Joint Surg 45:788 (1963)
2. Jacobs GR, Reinisch JF: Microcircular fibrinolysis after ischemİa: its relalion to vascular pateney and tissue sur-vival. Plast Reconstr Surg 68:737 (1981)
3. Angel MF, Mellow CG, Knİhht KR: Secondary isehemia
lime in rodents: conlrustiııg complete pedicle inlen uption with venous obstruetion. 85:789 (1990)
4. Güne! E, Çağlayan F: Treatment of inlestina! reperfusion injury using anttoxidative agents. i Pediatr Surg 33:1536 (1998)
5. Seatzler RK, Lchr HA, Barker JH: Visualizaüon of nulri-tive perfusion followirıg louıniquet isehemia in arterial pattern skin flaps: effecl of vasoaclive medication 94:652 (1994)
6. Petry JJ, Worthanı BA: The anatomy uf the epigastric (lap in the experimenta! rat. Plast Reconstr Surg. 74:4)0 (1984)
7. Sasaki HG, Pang CY: Memodynamics and viabîliıy of acute neurovascıılar island skin flaps in rals. Plasl Reconstr Surg. 65:152(1980)
8. Kerrigan C, Wizman P: Global flap isehemia: A compa-rison of arterial versus venous etioiogy. Plast and Reconstr Surg. 93:1485 (1994)
9. Komatsu S, Tamai S: Successful replantation of a comp-letelycut off thump. Plast Reconstr Surg. 68:374. (1968)
10. Manşon PM, Anthenclli RM: The role of oxygen free ra-dicals in isehemie tissue injury in island skin flaps. Ann Surg 198:87 (1983)
1 ]. May JW. Chait LA: The no-reflow phenomenon in expc-rimental free flaps. Plast Reconstr Surg. 61:256 (1978)
12. Rosen HM, Slivjak SM: Preischemic flap washout and its efl'eet on the no-rei"low phenomenon. Plast Reconstr Surg. 76:737 (1985)
13. Heden P, Sollei A: Circulatovy and metabolic everıts in pig island skin flaps after aıteıial or venous ocelusion. Plaits Recounts Surge. 84:475 (1989)
14. Hjordal VE: Myocutaneus flap isehemia: flow dynamics fo]lowing venous and arterial obstruetion. isehemia reperfusion injury dııe to venous slasis is a commonly en-counlered problem in free flap and replantation surgery Plast Reconstr Surg. 89:1083 (1992)
15. Hjordal VE: Venous isehemia iti skin flaps: mierocircu-latory iııtravascular thrombosis. Plast Reconstr Surg. 93:366 (1994)
16. Angel M, Ramasastry S: Free radicals: basic coııcepts concerning Iheir ehemistry, pathophysiology and relc-vance to plastic surgery. Plast and Rccons Surg. 79:990 (1987)
17. Hjordal VE, Hauge E: Difierential effecis of venous slasis and arterial insııfficicncy on tissue oxygenation in myocutaneus island flaps: an expci'inıental study in pigs. Piast Reconstr Surg. 89:521 (1992)
18. Wİzman P, Kcrrigan CL: Acııtc venous injuıy: Compari-son of secondary venous and arterial ocelusion. J Reconstr Microsurg 7:281 (1991)
19. Haıashina T: The rclutionship beıween venous ocelusion lime in island flaps and flap survivaîs. 60:92 (1977)

Thank you for copying data from http://www.arastirmax.com