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DENEYSEL ENDOTOKSEMİDE NİTRİK OKSİT SENT AZ İNHİBİTÖRLERİNİN ETKİLERİ

Journal Name:

  • İstanbul Tıp Fakültesi Dergisi

Publication Year:

  • 2001

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
The effects ofnitric oxide synthase inhibitör s in experimental endotoxemia. In this study, that has been planned to evaluate the probable role of nitric oxide in sepsis, in endotoxemic rats serum nitrite+nitrate levels, the changes in liver and kidney functions and the effects of nitric oxide synthase inhibitors to these alterations have been investigated. In experimental endoto-xemia, NG-nitro-L-argininine-mefhyl ester, has been administered at two different doses for increased serum nitrite+nitrate levels and organ dysfunctions and has decreased nitrite+nitrate levels, but has not revealed obvious effect on organ functions; however, selective inhibitör L-Canavanine, without effecting nitrite+nitrate levels, in low doses has caused liver dysfunction and in high doses provided evident improving effect. The results obtained in this study show that other mechanisms, in addition to nitric oxide, may play role in septisemia and nitric oxide synthase inhibition can have different effects beside this inhibition.
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Abstract (Original Language): 
Nitrik oksidin sepsisteki olası rolünü değerlendirmek üzere planlanan bu çalışmada, endotok-senıik sıçanlarda serum nitrit-nitrat düzeyleri ile karaciğer ve böbrek fonksiyonlarındaki değişiklikler ve bu değişikliklere nitrik oksit sentaz inhibitörlerinin etkileri araştırılmıştır. Deneysel endotoksemide artan nitrit-nitrat düzeyleri ve organ bozukluklarına karşı iki değişik dozda uygulanan nonselektif nitrik oksit sentaz inhibitörü NG-nitro-L-arginin-metil ester artan nitrit-nitrat düzeylerini anlamlı olarak düşürürken, organ fonksiyonlarına belirgin bir etki oluşturmamış, selektif inhibitör L-Kanavanin ise nitrit-nitrat düzeylerini etkilemeden, düşük dozda karaciğer fonksiyon bozukluğuna neden olup, yüksek dozda belirgin iyileştirici etkinlik sağlamıştır. Elde edilen sonuçlar septisemide nitrik oksit yanında başka mekanizmaların rol oynayabileceğini ve nitrik oksit sentaz inhibitörü drogların ise bu inhibisyon yanında başka etkinliklere sahip olabileceğini ortaya koymuştur
FULL TEXT (PDF): 
PDF icon arastirmax-deneysel-endotoksemide-nitrik-oksit-sent-az-inhibitorlerinin-etkileri.pdf
  • 4
301-306
  • Turkish

REFERENCES

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