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HİPERFİBROTİK MİYELODİSPLASTİK SENDROM: İKİ OLGUNUN SUNUMU

Journal Name:

  • İstanbul Tıp Fakültesi Dergisi

Publication Year:

  • 2001

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Hyperfibrotic Myelodisplastic Syndrome: Report of Two Cases: Myelodisplastic syndrome (MDS) is a heterogenous group of hematological disorders characterized by persistent cytope-nia in peripheral blood, dysplastic and ineffective hematopoiesis in bone marrow and an incre-ased risk of transformation to acute leukemia. Bone marrow fibrosis (myelofibrosis) may ac-company some MDS cases who had previous antineoplastic therapy, but extremely rare in unt-reated MDS cases. Here we report clinical, pathological and radiological characteristics of two hyperfibrotic MDS cases.
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Abstract (Original Language): 
Myelodisplastik sendrom (MDS), çevre kanında sitopeniler, kemik iliğinde displastik ve ine-fektif eritropoez ile seyreden ve akut lösemiye dönüşüm riski olan heterojen bir grup hastalığın ortak adıdır. Antineoplastik tedavi alan MDS olgularında kemik iliğinde fibroz gelişebilir, ancak tedavi görmemiş olgularda ileri derecede fibroz oldukça nadirdir. Bu yazıda hiperfibro-tik MDS saptanan iki olgunun klinik, patolojik ve radyolojik bulguları sunulmaktadır.
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  • 4
310-315
  • Turkish

REFERENCES

References: 

1. Harris NL, Jaffe ES, Diebold J, Flandrin G, Muller-Her-melink HK, Vardiman J, Lister TA, Bloomfield CD: The World Health Organization classification of neoplasms of the hematopoietic and lymphoid tissues: Report of the cli-nical advisory committee Meeting- Airlie House, Virginia, November, 1997. The Hematology Journal 1:53 (2000).
2. Lambertenghi-Deliliei's G, Orazi A,Luksch R, Annaloro C, Soligo D: Myelodisplastic syndrome with increased marrow fibrosis: a distinct clinico-pathological entity. Br J Haematol 78:161 (1991).
3. Narayanan MN, Benaim ME, Geary CG, Harrison CJ: Hyperfibrotic myelodysplasia. Br J Haematol (letter) 79:653 (1991)
4. Pagliuca A, Layton DM, Manoharan A, Gordon S, Green PJ, Mufti GJ: Myelofibrosis in primary myelodisplastic syndromes: a clinico-morphological study of 10 cases. Br J Haematol 71:499 (1989)
5. Reilly JT, Dolan G: Proposed classification for the myeldysplasia/myelofibrosis syndromes. Br J Haematol (letter) 79:653 (1991).
6. Watts EJ, Majer RV, Green PJ, Mavor WO: Hyperfibrotic myelodisplasia: a report of three cases shovving haemato-logical remission following treatment with prednisolone. Br J Haematol (letter) 78:120 (1991).

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