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KARACİĞER SİROZUNDA ORTALAMA ERİTROSİT HACMİNİN DEĞERLENDİRİLMESİ

Journal Name:

  • İstanbul Tıp Fakültesi Dergisi

Publication Year:

  • 2001

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Evaluation ofthe mean corpuscular volume (mcv) in liver cirrhosis. Introduction and aim: In chronic liver diseases some changes in hematologic parameters are observed. The aim of this study is to investigate the relationship between MCV and aetiology as well as the severity of liver cirrhosis. Our patients (n:358) were divided into three groups; cirrhosis due to alcohol (group I), alcohol associated with any other aetiologic factors (group II) and any aetiologic factor other than alcohol (group III). MCV values in each group were determined and compared. We also inves-tigated the relationship betvveen MCV values and the Child-Pugh's stage. MCV values were found to be significantly higher in Child B than Child A and Child C than Child B (Child A-B p<0.001, Child B-C p<0<001, Child A-C p<0.0001). MCV values and Child-Pugh scores were found to have positive correlation and increased each other (r=0.3 p<0.01). Macrocytosis is frequently encountered also in liver cirrhosis due to causes other than alcohol. MCV values increase parellel to hepatic dysfunction.
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Abstract (Original Language): 
Kronik karaciğer hastalıklarında hematolojik parametrelerde değişiklikler sık görülmektedir. Bu çalışmanın amacı, karaciğer sirozunun etiyolojisi ve karaciğer fonksiyon bozukluğunun derecesi ile ortalama eritrosit hacmi (MCV) arasındaki ilişkileri araştırmaktır. Karaciğer sirozu tanısı konmuş 358 vaka, alkole bağlı, alkol ve bir başka etiyolojiye bağlı ve alkol dışı etiyolojiye bağlı olan karaciğer sirozu olmak üzere üç grupda incelenmiştir. Ortalama eritrosit hacmi ile Child-Pugh evrelemesi arasındaki ilişkiler araştırılmıştır. MCV, Child C olan vakalarda, Child A ve B'ye göre, Child B olan vakalarda ise Child A'ya göre anlamlı derecede yüksek bulunmuştur (Child A-B p<0.001, Child B-C p<0<001, Child A-C p<0.0001). Child-Pugh skoru ile ortalama eritrosit hacmi arasında pozitif korelasyon saptanmıştır (r=0.3, p<0.001). Makrositoz, alkol dışı etiyolojiye bağlı karaciğer sirozu vakalarında da sık görülmektedir. Ortalama eritrosit hacmi, karaciğer fonksiyon bozukluğuna paralel olarak artmaktadır
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PDF icon arastirmax-karaciger-sirozunda-ortalama-eritrosit-hacminin-degerlendirilmesi.pdf
  • 4
296-300
  • Turkish

REFERENCES

References: 

1. Alling C, Gustavsson L, Kristensson-Aas A, Wallerstedt S: Changes in fatty acid composition of majör glycerop-hospholipids in erythrocyte membranes from chronic al-coholics during withdrawal. Scand J Clin Lab Invest 44: 283(1974).
2. Chalmers DM, Chanarin I, MacDermott S, Levi AJ: Sex-related differences in the haematological effects of ex-cessive alcohol consumption. J Clin Pathol 33: 3 (1980).
3. Chanarin I: Haemopoiesis and alcohol. Br Med Bull 38: 81 (1982).
4. Clemens MR, Kessler W, Schied HW, Schupmann A, VValler HD: Plasma and red celi lipids in alcoholics with macrocytosis. Clin Chim Açta 156: 321 (1986).
5. Cooper RA: Hemolytic syndromes and red celi membra-ne abnormalities in liver disease. Semin Hematol 17: 103 (1980).
6. Dzik WH, Jenkins RL: Renal failure from ABO hemoly-sis due to anti-A of graft origin following liver trans-plantation. Transfusion 27: 550 (1987).
7. Friedman LS, Maddrey WC: Surgery in the patient with liver disease. Med Clin North Am 71: 453 (1987).
8. Hines JD, Cowan DH: Anemia in alcholism, In: Dimit-rov NV, Nodine JH (Eds): Drugs and Hematologic Reac-tions. New York, Grune & Stratton, 141 (1974).
9. Lelbach WK: Cirrhosis in the alcoholic and the relation to the volume of alcohol abuse. Ann NY Acad Sci 5: 252 (1974).
10. Lindenbaum J: Hematologic complications of alcohol abuse. Semin Liver Dis 7: 169 (1987).
11. Lindenbaum J: Folate and B12 vitamin deficiencies in al-coholism. Semin Hematol 17: 119 (1980).
12. Lindenbaum J: Drug-induced folate deficiency and the hematologic effects of alcohol. Lindenbaum J (Ed): Nut-rition in Hematology. New York, Churchill Livingstone, 33(1983). 299
Karaciğer Sirozunda Ortalama Eritrosit Hacminin Değerlendirilmesi
13. Ludwig J, Moyer TP, Rakela J: The liver biopsy diagno-sis of Wilson's disease: methods in pathology. Am.J Clin Pathol 102:443(1994).
14. Owen JS, Brown DJC, Harry DS, Mclntyre N, Beaven GH, Isenberg H, Gratzer WB: Erythrocyte echinocytosis in liver disease. Role of abnormal plasma high density li-poproteins. J Clin Invest 76: 2275 (1985).
15. Unger KW, Johnson D: Red blood celi mean corpuscular volume. A potential indicator of alcohol usage in a wor-king population. Am J Med Sci 267: 218 (1974).
16. Walshe JM: Copper: not too little, not too much, but just right. J RCP 29: 280 (1995).
17. Werre JM, Helleman PW, Verloop MC, De Gier J: Cau-ses of macroplania of erythrocytes in diseases of the liver and biliary tract with special reference to leptocytosis. Br JHaematoll9: 223 (1970).
18. Wu A, Chanarin I, Levi AJ: Macrocytosis of chronic al-coholism. Lancet 1: 829 (1974).

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