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SAĞLIKLI KİŞİLERDE DÜŞÜK DANSİTELİ LİPOPROTEİNLERİN KOLESTEROL İÇERİĞİ İLE PEROKSİDASYON POTANSİYELİ ARASINDAKİ İLİŞKİNİN İNCELENMESİ

Journal Name:

  • İstanbul Tıp Fakültesi Dergisi

Publication Year:

  • 2001

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
The investigation of relationship between cholesterol content and peroxidation potential oj low density lipoproteins in healthy subjects. In this study, we determined endogenous diene conjugate levels and the susceptibility to copper-induced lipid peroxidation of low density lipoproteins (LDL) isolated by precipitation with buffered heparin from plasma in healthy 50 subjects, aged 27-79 years (means 56.6, SD 19.4). Positive coırelations were found to exist betvveen LDL endogenous diene conjugate levels, copper-induced malondialdehyde levels and LDL-cholesterol content. According to these findings, we can say that the oxidation potential of LDL may be related to LDL-cholesterol content
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Abstract (Original Language): 
Yaşlan 27-79 arasında değişen (ort. 56.6, SD 19.4) 50 sağlıklı kişinin plazmasından tampon-lanmış heparin kullanılarak elde edilen düşük dansiteli lipoprotein (LDL) fraksiyonunda endo-jen dien konjugat düzeyleri ve bakırla inkübasyon sonrası oluşan malondialdehit (MDA) düzeyleri ölçüldü. LDL'nin endojen dien konjugat düzeyleri ve bakırla inkübasyon sonrası oluşan malondialdehit düzeylerinin LDL'nin kolesterol içeriğiyle pozitif korelasyon gösterdiği saptandı. Bu bulgulara göre, LDL'nin oksidasyon potansiyelinin kolesterol içeriği ile yakın bir ilişki gösterdiğini söyleyebiliriz
FULL TEXT (PDF): 
PDF icon arastirmax-saglikli-kisilerde-dusuk-dansiteli-lipoproteinlerin-kolesterol-icerigi-ile-peroksidasyon-potansiyeli-arasindaki-iliskinin-incelenmesi.pdf
  • 4
281-284
  • Turkish

REFERENCES

References: 

1. Ahotupa M, Ruutu M, Mantyla E: Simple methods of qu-antifying ojddation products and antioxidant potential of low density lipoproteins. Clin Biochem 29: 139 (1996).
2. Ahotupa M, Vasankari TJ: Baseline diene conjugation in LDL lipids: An indicator of circulating oxidized LDL. FreeRadical BiolMed27: 1141 (1996).
3. Bettridge DJ, Morrell JM: Lipids and Coronary Heart Di-sease. Chapman and Hail Medical, London (1998).
4. Buege JA and Aust JD: Microsomal lipid peroxidation. Method Enzymol 52: 302 (1978).
5. Doğru-Abbasoğlu S, Kanbağlı Ö, Bulur H, Babalık E, Öztürk S, Aykac-Toker G, Uysal M: Lipid peroxides and antioxidant status in serum of patients with angiographi-cally defined coronary atherosclerosis. Clin Biochem 32: 671 (1999).
6. Esterbauer H, Gebicki J, Puhl H, JUrgens G: The role of peroxidation and antioxidants in oxidative modification of LDL. FreeRadical Biol Med 13: 341 (1992).
7. Grundy SM: Atlas of Lipid Disorders, Cholesterol, Atherosclerosis and Coronary Heart Disease, Gower Medical Publ., New York (1990).
8. Gugliucci A, Menini T, Stahl AJC: Susceptibility to cop-per-enhanced autoxidation of VLDL+LDL fractions from diabetic patients. Biochem Mol Biol İnter 32: 139 (1994).
9. Halevy D, Thiery J, Nagel D, Arnold S, Erdmann E, Höfling B, Cremer P, Seidel D. Increased oxidation of LDL in patients vvith coronary artery disease is indepen-dent from dietary vitamins E and C.Arterioscler Thromb VascBiol 17: 1432 (1997).
10. Halliwell B and Gutteridge JMC: The antioxidants of hu-
man extracellular fluids. Arch Biochem Biophys 280: 1 (1990).
11. Itabe H: Oxidized phospholipids as a new landmark in atherosclerosis. Prog Lipid Res 37: 181 (1998).
12. Jialal I, Devaraj S: Low-density lipoprotein oxidation, antioxidants and atherosclerosis: a clinical biochemistry perspective. Clin Chem 42: 498 (1996).
13. Mehmetçik G, Toker G, Uysal M: Endogenous and copper-induced lipid peroxidation and antioxidant activity of serum in hypercholesterolemic subjects. Horm Metab Res 29: 63 (1997).
14. Özdemirler G, Öztezcan S, Toker G, Uysal M: Peroxida-tion status of erythrocytes and apolipoprotein B contai-ning lipoproteins in hypercholesterolemic subjects. Inter-nat J Vit Nutr Res67:130(1997).
15. Sattler W, Maile E, Kostner GM: Methodological appro-aches for assessing lipid and protein oxidation and modification in plasma and isolated lipoproteins. Method Mol Biol 110: 167(1998).
16. Schwenke DC: Antioxidants and atherogenesis. J Nutr Biochem 9: 424 (1998).
17. Uysal M: Ateroskleroz, kalb-damar hastalıkları ve serbest radikaller. Aktüel Tıp Dergisi 5: 15 (2000).
18. Uysal M, Kanbağlı Ö, Doğru-Abbasoğlu S, Mehmetçik G, Özdemirler G, Aykac-Toker G: Aterosklerozla ilişkili hastalıklarda lipit peroksidasyonu ve antioksidan sistem üzerine incelemeler. Osmangazi Üniversitesi Tıp Fakültesi Dergisi 20: 141 ( 1999)
19. Uzel N, Sivas A, Uysal M, Öz H: Studies on serum pero-xides in normolipidemic and hyperlipidemic individuals. IRCS Med Sci 13: 1039(1985).
20. Van de Vijyer LPL, Kardinaal AFM, Van Duyvenvoorde W, Kruijssen DACM, Grobbee DE, Van Poppel G, Prin-cen HMG: LDL oxidation and extent of coronary atherosclerosis. Aıterioscler Thromb Vasc Biol 18: 193 (1998).
21. Wieland H, Seidel D: A simple specific method for pıe-cipitation of low density lipoproteins. J Lipid Res 24: 904 (1983).
22. Yla-Herttuala S: Is oxidized low-density lipoprotein presem in vivo? Curr Opin Lipidol 9: 337 (1998).
23. Yla-Herttuala S, Palinski W, Rosenfeld ME, Parthasa-rathy S, Carew TE, Butler S, Witztum JL, Steinberg D: Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man. J Clin İnvest 84: 1086 (1989).
24. Zhang A, Vertommen J, Van Gaal L, De Leeuvv I: A ra-pid and simple method for measuring the susceptibility of low-density-lipoprotein and very-low-density-lipopıo-tein to copper-catalyzed oxidation. Clin Chim Açta 227: 159(1994).

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