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ST ELEVASYONSUZ AKUT KORONER SENDROMLARDA TROPONİN T POZİTİFLİĞİNİN KORONER RİSK FAKTÖRLERİ, SOL VENTRİKÜL FONKSİYONLARI, ANJİOGRAFİ BULGULARI VE UZUN SÜRELİ PROGNOZ İLE İLİŞKİSİ

Journal Name:

  • İstanbul Tıp Fakültesi Dergisi

Publication Year:

  • 2001

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Relations between troponin T positivity and coronary risk factors, left ventricıdar function, coronary angiographic findings and loııg term prognosis in patients with acute coronary syndrome without ST eievation. Troponin T positivity is a strong predictor of advers outco-mes in patients with acute coronary syndrome without ST eievation. We analyzed fhe relations betvveen troponin T (TnT) positivity and coronary risk factors, left ventricular function, coronary angiography findings and long term follow-up results in patients with acute coronary syndrom without ST eievation. Ninty eight patients were enrolled (34 female, 64 male, mean age 59.4+ 11.6 years) in the study. TnT was positive in 50 patients (51%) and negative in 48 patients (49%). Coronory angiography was performed in 75 patients (76.5%). The mean num-ber of the vessel with significant stenosis was 2.1 ± 0.9% in TnT positive and 1.4 + 1.2 (p=0.004) in TnT negative patients. Follow-up data was available in 62 patients (63%) and mean follow-up time was 367 days (range 35-755 days). Eight patients was died in this fol-low-up period and ali of them were from TnT positive group (p:0.025). Majör advers cardiac event rate was 31.4% in TnT positive and 9.5% in TnT negative group (p=0.048). In conclusi-on, the results of our study suggest that in acute coronary syndrome vvithout ST eievation, TnT positive patients have more severe coronary artery disease and poor prognosis. In this patient group more active therapeutic approach may be beneficial.
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Abstract (Original Language): 
ST elevasyonsuz akut koroner sendromlarda troponin pozitifliği, gelişebilecek kardiyak olayların kuvvetli bir öngördürUcüsüdür. Çalışmamızda ST elevasyonsuz akut koroner sendromlarda troponin T'nin (TnT) koroner risk faktörleri, ventrikül fonksiyonları, koroner anjiografi bulguları ve uzun süreli takip sonuçları ile ilişkisi araştırıldı. Çalışmaya alman 98 hastanın (34 kadın, 64 erkek, ortalama yaş 59.4± 11.6) %51'inde (n: 50) TnT pozitif, %49'unda (n: 48) negatif bulundu. Koroner risk faktörleri ve sol ventrikül fonksiyonları ile TnT pozitifliği ve kantitatif değerleri arasında anlamlı bir ilişki saptanmadı. 98 hastanın 75'ine (%76.5) koroner anjiografi yapıldı. TnT pozitif olan hastalarda anlamlı darlık gösteren damar sayısı ortalama 2.1 ± 0.9 ve negatif olanlarda 1.4 + 1.2 (p=0.004) idi. 62 hasta (%63) ortalama 367 (35-755) gün takip edildi. Bu süre içinde 8 hasta vefat etti, bu hastaların tamamı TnT pozitif gruptandı (p: 0.025). Takip süresince majör kardiyak olay sıklığı TnT pozitif grupta %31.4 ve negatif grupta %9.5 olarak bulundu (p=0.048). Sonuç olarak, çalışmamızın bulguları ST elevasyonsuz akut koroner sendromlarda TnT pozitif bulunan hastalarda koroner arter hastalığının daha ciddi ve prog-nozun daha kötü olduğuna işaret etmektedir. Bu hastalarda daha aktif bir tedavi yaklaşımının yararlı olacağı düşünülebilir.
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PDF icon arastirmax-st-elevasyonsuz-akut-koroner-sendromlarda-troponin-t-pozitifliginin-koroner-risk-faktorleri-sol-ventrikul-fonksiyonlari-anjiografi-bulgulari-uzun-sureli-prognoz-ile.pdf
  • 4
199-207
  • Turkish

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