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ŞİŞMAN KADIN HASTALARDA PLAZMA LEPTİN DÜZEYLERİ; YAĞ MİKTARI, DAĞILIMI VE İNSÜLİN DÜZEYLERİ İLE İLİŞKİSİ

Journal Name:

  • İstanbul Tıp Fakültesi Dergisi

Publication Year:

  • 2002

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Leptin concentrations in relation to overall adiposity, fat distribution and plasma insülin le-vels in obese women. The aim of this study is to examine the associations between leptin le-vels and BMI, fat distribution and serum insülin levels in obese women. 125 premenouposal obese women and 25 normal-vveight women participated in the study. Leptin levels in obese women were significantly higher than controls (26.4+16.8 vs 11.7+4.9 ng/mL, p<0.001). In obese women, leptin levels were significantly correlated with BMI (r: 0,3433), vvaist circumfe-rence (r: 0.3278), insülin (r: 0,2466) and HOMA (r: 0,2971). Our data suggested a significant relationship between leptin concentration and BMI (a surrogate for overall adiposity) and indi-cated that leptin levels might be a marker for the existence of insülin resistance.
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Abstract (Original Language): 
Diabetik olmayan menopoz öncesi şişman kadınlarda plazma leptin düzeyleri ile vücut yağ miktarı, yağ dağılımı ve insülin düzeyleri arasındaki ilişkiyi araştırmak amacıyla 125 preme-nopozal şişman kadın ve 25 normal ağırlıklı kadın çalışma kapsamına alındı. Şişman kadınlarda leptin düzeyi normal ağırlıklı kadınlardan anlamlı olarak yüksek bulundu (26.4+16.8 ve 11.7+4.9 ng/mL, p<0.001), ayrıca leptin düzeyleri ile BMI (r: 0,3433), bel çevresi (r: 0.3278), insülin (r: 0,2466) ve HOMA (r: 0,2971) arasında anlamlı ilişkiler bulundu. Bulgular, şişman kadınlarda leptin düzeyleri ve BMI ile temsil edilen total vücut yağlanması arasında anlamlı ilişkilerin bulunduğunu ve leptin düzeylerinin bir insülin direnci göstergesi olabileceğini yansıtmaktadır.
FULL TEXT (PDF): 
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  • 1
25-29
  • Turkish

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