You are here

Home » Content

UYKUSUZLUK SÜRESİNCE VE SONRASINDA OPSONIZASYON

Journal Name:

  • İstanbul Tıp Fakültesi Dergisi

Publication Year:

  • 2002

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Opsonization during and after sleep deprivation. The present study was undertaken to investi-gate the effects of fourty-eight hours of sleep deprivation on opsonization which is one of the determinants of phagocytic activity. Ten young healthy male subjects were included the study. After the physical examination, subjects were recorded for one night with polysomnography (PSG) to exclude sleep pathologies. Following PSG, subjects undervvent to continuous wake-fulness under sedentary conditions. At the end of fourty-eight hours, they were allowed for re-covery sleep. Venous blood samples were collected at 0 - 24th - 48th and 72nd hours. Cortisol, IgG measurements and opsonization test was performed in blood samples by using classical method. Our results showed that 48 hours [L.Ö.ljof sleep deprivation did not lead to any alte-ration in opsonization
Bookmark/Search this post with
Abstract (Original Language): 
Bu çalışmada, 48 saat uykusuzluğun, fagositik aktiviteyi belirleyen göstergelerden biri olan opsonizasyon üzerine etkileri araştırıldı. Sağlıklı, genç erişkin 10 erkek gönüllü çalışmaya dahil edildi. Fizik muayene sonrasında, denekler, uyku bozukluğu açısından değerlendirilmek amacıyla bir gece poligrafik uyku kayıdma alındılar. Uyku tetkikini takiben 48 saat süre ile se-danter koşullarda uykusuz bırakılan denekler, yine kayıt altında telafi uykularını uyudular. 0 -24 - 48 ve 72. saatlerde venöz kan örnekleri toplandı. Alman kan örneklerinde kortizol, IgG ve klasik protokole uygun olarak opsonizasyon değerlendirildi. Sonuçlarımıza göre, 48 saat uykusuzluğun, sağlıklı insanlarda opsonizasyonda anlamlı bir değişikliğe neden olmadığı saptandı.
FULL TEXT (PDF): 
PDF icon arastirmax-uykusuzluk-suresince-sonrasinda-opsonizasyon.pdf
  • 1
34-38
  • Turkish

REFERENCES

References: 

1. Benca RM, Kushida CA, Everson CA, Kalski R, Beıg-mann BM, Rechtschaffen A: Sleep deprivation in the rat: VII. Immune function. Sleep 12: 47 (1989).
2. Bergmann BM, Gilliland MA, Feng PF, Russel DR, Shaw P, Wright M, Rechtschaffen A, Alverdy JC: Are physiological effects of sleep deprivation in the rat medi-ated by bacterial invasion? Sleep 19: 554 (1996).
3. Dickstein JB, Moldofsky H: Sleep, cytokines and immu-ne function. Sleep Med Rev 3: 219 (1999).
4. Dinges DF, Douglas SD, Hamarman S, Zaugg L, Kapoor S: Sleep deprivation and human immune function. Adv in Neuroimmunol 5:97 (1995).
5. Dinges DF, Douglas SD, Zaugg L, Campbell DE, McMann JM, Whitehouse WG, Orne EC, Kapoor SC, icaza E, Orne MT: Leukocytosis and natural killer celi function parallel neurobehavioral fatigue induced by 64 hours of sleep deprivation. J Clin Invest 93: 1930 (1994).
6. Everson CA: Functional consequences of sustained sleep deprivation in the rat. Behav Brain Res 69: 43 (1995).
7. Everson CA: Sustained sleep deprivation impairs host defense. Am J Physiol 265: Rl 148 (1993).
8. Irwin M, Mascovich A, Gillin JC, Willoughby R, Pike J, Smith TL: Partial sleep deprivation reduces natural killer celi activity in humans. Psychosom Med 56: 493-498 (1994).
9. Invin M, McClintick J, Costlovv C, Fortner M, White J, Gillin JC: Partial night sleep deprivation reduces natural killer and cellular immune responses in humans. FASEB J 10: 643 (1996).
10. Melchart D, Martin P, Hallek M, Holzmann M, Jurcic X, Wagner H. Circadian variation of the phagocytic activity of polymorphonuclear leukocytes and of various other parametersin 13 healthy male adults. Chronobiol Int 9: 35 (1992).
11. Moldofsky H, Lue FA, Davidson JR, Gorczynski R: Effects of sleep deprivation on human immune functions. FASEB J 3: 1972(1989).
12. Moldofsky H, Lue FA, Davidson JR, Jephthah-Ochola J, Carayanniotis K, Gorczynski R: The effect of 64 hours of wakefulness on immune functions and plasma cortisol in human. In: Sleep'88, ed. J. Horne, Gustav Fischer Ver-lag, Stuttgart, sayfa: 185 (1989).
13. Moldofsky H, Lue FA, Shahal LB, Jiang CG, Gorczynski R: Diurnal sleep/vvake-related immune functions du-ring the menstrual cycle of healthy young women. J Sleep Res 4: 150(1995).
14. Moldofsky H: Sleep and the immune system. Int J Im-munopharmac 17: 649 (1995).
15. Öztürk L, Pelin Z, Karadeniz D, Kaynak H, Çakar L, Gö-zükırmızı E: Effects of 48 hours sleep deprivation on human immune profile. Sleep Research Online 2: 107 (1999).
16. Palmblad J, Cantell K, Strander H, Froberg J, Karlsson C, Levi L, Ganstrom M, Unger P: Stressor exposure and immune response in man: Interferon proucing capacity and phagocytosis. J Psychosom Med 20: 193-199 (1976).
17. Rechtschaffen A, Kales A: A Manual of standardized ter-minology, techniques and scoring system for sleep stages of human subjects. Los Angeles: Brain Information Service/B rain Research Institute, (1968).
18. Terzioğlu M, Yiğit G, Oruç T: Fizyoloji Ders Kitabı Cilt II, İ.Ü. Basımevi ve Film Merkezi, İstanbul (1993), s: 134-144.

Thank you for copying data from http://www.arastirmax.com