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SİTOZİN-ARABİNOZİD'E BAĞLI AKUT SEREBELLAR SENDROM: OLGU SUNUMU

Journal Name:

  • İstanbul Tıp Fakültesi Dergisi

Publication Year:

  • 2002

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Acule cerebellar syndrome releated to cytosine-arabinoside: Case report. Cytosine arabinosi-de (cytarabine) is a chemotherapeutic agent that is widely used in the treatment of acute mye-loblastic leukemia (AML). It is known that af ter high dose cytarabine treatment, neurologic side effects can occur. In this case report, an AML patient is reported in whom acute cerebellar syndrome has occur-red after high dose cytarabine treatment. In his 2 months progress wifh supportive treatment, a mild clinical improvement in his neurologic symptoms and signs is observed. In this report, risk factors for cytarabine neurotoxicity and treatment alternatives are discussed.
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Abstract (Original Language): 
Sitozin Arabinozid (sitarabin) özellikle akut miyeloblastik lösemi(AML)'lerde sık olarak kullanılan kemoterapötik bir ajandır. Yüksek doz tedavi sonrasında nörolojik yan etkilerinin olabileceği bildirilmiştir. Bu olgu sunumunda yüksek doz tedavi sonrası akut serebellar sendrom gelişen ve 2 aylık izleminde destek tedavi ile nörolojik bulgularında hafif düzelme saptanan bir AML olgusu sunulmuş, nörolojik yan etkilerin gelişimi için risk faktörleri ve tedavi olanakları tartışılmıştır
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  • 3
204-205
  • Turkish

REFERENCES

References: 

1. Baker WJ: Cytarabine and neurologic toxicity. J Clin On-col 10:169(1992).
2. Friedman JH: Permanent cerebellar toxicity of cytosin ara-binoside(ARÂ-C) in a young vvoman. Mov Disord 16:575 (2001).
3. Winkelman MD, Hines JD: Cerebellar degeneration cau-sed by high dose cytosine arabinoside: a clinicopathologi-cal study. Ann Neurol 14: 520 (1983).
4. Zavvacki T, Friedman JH, Grace J, Shetty N: Cerebellar toxicity of cytosine arabinoside: Clinical and neuropsy-chological signs. Neurology 55:1234 (2000).

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