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KRONİK BÖBREK YETMEZLİĞİ OLAN HASTALARDA TÜMÖR BELİRLEYİCİLERİNİN DEĞERLENDİRİLMESİ

Journal Name:

  • İstanbul Tıp Fakültesi Dergisi

Publication Year:

  • 2003

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
The assessment of tumor markers in the patients with ehronic renal failure. In thc literatüre some studics showed that serum levels of some tumor markers inerease in patients with ehronic renal failure, despite the absence of malignaııcy. The aim of thİs study was to İnvestigate serum levels of different tumor markers such as alpha fetoprotein (AFP), carcinoembryonic antigen (CEA), cancer antigen 125 (CA 125), carbohydrate antigen 19-9 (CA 19-9), carbohy-drate antigen 15-3 (CA15-3), prostaıic specifie antigen (PSA) in 36 predİalysis, 42hemodialy-sis (HD) and 26 conlinuous ambulatory peritoneal dialysİs (CAPD) patients as well as 22 he-atthy controls who had not malignaney and negative hepatitis markers profile wcre enrolled. The mcan CEA and CA 19-9 levels were found to be higher than the control group in predİalysis patients, HD patient and CAPD patient groups. In addition serum CA 125 level in CAPD patients group was found higher than the other groups. Serum AFP, CA 15-3 and PSA levels were similar in ali groups. Howcver ali serum tumor markers levels vvere in normal rau-ge İn al! the patients. To conelude, serum tumor markers do not have diagnostic significance in patients with ehronic renal failure. These markers should not be studied out of research projects in this patient population wİthout malignaney suspİcion.
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Abstract (Original Language): 
Literatürde bazı çalışmalarda kronik böbrek yetmezlikli hastalarda bir malignite olmamasına rağmen bazı tümör belirleyicilerinin arttığı gösterilmiştir. Bu çalışmada malignİtesi olmayan ve hepatit belirleyicileri negatif olan 36 prediyaliz, 42 hemodiyaliz (HD), 26 sürekli ayaktan periton diyalizi (SAPD) hastalarında ve 22 sağlıklı kontrolde farklı tümör belirleyicilerinden serum a-fetoproteİn (AFP), karsinoembriyojenik antijen (CEA), karbonhidrat antijen 125 (CA 125), karbonhidrat antijeni 19-9 (CA 19-9), karbonhidrat antijeni 15-3 (CA15-3), prostat spesifik antijen (PSA) seviyelerine bakıldı. Prediyaliz, hemodiyaliz ve periton diyalizi hastalarının ortalama serum CEA ve CA 19-9 düzeyleri kontrol grubuna göre yüksek bulundu. Ayrıca SAPD hastalarında CA 125 düzeyi diğer gruplara ve kontrol grubuna göre yüksekti. Serum AFP, CA 15-3 ve PSA düzeyleri bütün gruplarda benzerdi. Ancak tüm tümör belirleyicilerinin bütün hastalarda normal laboratuvar sınırları içerisinde olduğu görüldü. Serum tümör belirleyicilerinin kronik böbrek yetmezliği hastalarında tanısal öneminin olmadığı görülmüştür ve malignite şüphesi olmayan kronik böbrek yetmezlikli hastalarda araştırma projeleri dışında çalışılmasına gerek yoktur.
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  • Turkish

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