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SON DÖNEM BÖBREK YETMEZLİĞİNDEKİ DEMİR EKSİKLİĞİ ANEMİSİNİN İNTRAVENÖZ DEMİR SÜKROZ İLE TEDAVİSİ

Journal Name:

  • İstanbul Tıp Fakültesi Dergisi

Publication Year:

  • 2003

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
The effect of iron sucrose in iron defîcieney anaeınia of end-stage. renal disease, Iron defici-eney is onc of the most important causes of anaemİa associaled with end-stage renal disease (ESRD) and there is no standard approach for the treatment. In this sludy we aimcd to study the effect and side effects of intravenous iron sucrose use İn patients with newly diagnosed ESRD and iran deficieney anaemia. 46 patients (31 female, 15 male) with newly diagnosed ESRD and iron deficieney anaemia were cnrolled into this study. The total need of iron of the patients was caiculated. The patients were taken to bicarbonate hemodialysis for two hours during six days. The first day, intravenous 25mg iron sucrose (Venofer®) vvas gİven to the patients as a test dose, the second day intravenous 1 OOmg was given in 30 minutes; after the second day 300mg/day were given unlil completc total iron deficit vvas replaced complefeiy. Haemoglobin (Hb), haematocrit (Hct), mcan corpuscular volumc (MCV), serum iron(Fc), serum iron binding capacİty (FeBC), trans-ferrin saturatİon (TS) and ferritin levels were studied before treatment and after four vveeks follovving treatment. The pretreatment levels of Hb, Hct, MCV, Fe, FeBC, TS and ferritin werc 7.6±0.6g/dl, 22.9±1.5%, 65±12fl, 28.6±12mcg/di, 378.6±39.8mcg/dl, 11.8±6.6%, 26.6±12.7ng/ml respeeti-vely. After four weeks they wcre 10.2±0.9g/dİ, 30.5+2.6%, 89.6+8fl, 68.6+24mcg/dl, 238.7+41 mcg/dl, 28.8±10.9%, 368.8+221ng/ml respeetively. The inereased mean levels of Hb, Hct, MCV, Fe, TS, ferritin and decreased serum level of FeBC were found as statistically significant (p<0.001). No side effect of the drııg was seen in the patients. The daily usagc of iron sucrose after hemodialysis session in patients wi(h newly diagnosed ESRD and iron deficieney was found to be safe and efficient.
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Abstract (Original Language): 
Son dönem böbrek yetmezliği (SDBY)'ndc görülen aneminin en önemli nedenlerinden biri de demir eksikliğidir ve tedavisinde standart bir yaklaşım mevcut değildir. Biz bu çalışmada yeni SDBY tanılı ve demir eksikliği anemili hastalarda İntravenöz demir sükroz kullanımının etkisini ve yan etkilerini araştırmayı amaçladık. Bu çalışmaya yeni SDBY tanısı konulan ve demir eksikliği tespit edilen 46 (31 kadm, 15 erkek) hasta alındı. Hastaların demir ihtiyacı hesaplandi. Hastalara altı gün boyunca her gün 2 saat bikarbonattı hemodiyaliz yapıldı. İlk gün demir sükroz (Venofer®) 25 mg intravenöz test dozu kontrollü olarak uygulandı, ikinci gün lOOmg intravenöz 30 dakikada verildi. İkinci günden sonra, total demir dozu tamamlanana kadar günde 300 mg demir sükroz verildi. Hastalanıl tedavi öncesinde vc tedavi tamamlandıktan 4 hafta sonra hemoglobin (Hb), hematokrit (Hct), ortalama eritrosit hacmi (OEH), serum demir (Fe), demir bağlama kapasitesi (FeBK), transferlin saturasyonu (TS) ve ferritin düzeyleri araştırıldı. Tedavi öncesi ortalama Hb, Hct, OEH, Fe, FeBK, TS ve ferritin düzeyleri sırasıyla 7.6±0.6g/dl, %22.9±1.5, 65±12fl, 28.6±12mcg/dl, 378.6±39.8mcg/dl, %li.8±6.6, 26.6±12.7ng/ml iken 4 hafta sonra sırasıyla 10.2+0.9g/dl, %30.5±2.6, 89.6±8fi, 68.6±24mcg/dl, 238.7±41mcg/dl, %28.8±10.9, 368.8+22lng/ml bulundu. Ortalama Hb, Hct, OEH, Fe, TS vc ferritin düzeylerindeki artış ve FeBK'deki düşüş istatistiksel olarak anlamlı bulundu (p<0.001). Hastaların hiçbirinde ilaca bağlı yan etki gözlenmedi. Yeni SDBY tanısı konulmuş ve demir eksikliği saptanmış olan hastalarda, günlük hemodiyaliz sonrası demir sükrozun İntravenöz olarak uygulanması güvenli ve etkili bulunmuştur
FULL TEXT (PDF): 
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  • Turkish

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