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0-2 YAŞ ARASI ÇOCUKLARDA SAÇ KURŞUN DÜZEYLERİ VE KRONİK KURŞUNA MARUZ KALMA NEDENLERİ

Journal Name:

  • İstanbul Tıp Fakültesi Dergisi

Publication Year:

  • 2003

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
SUMMARY llair lead levels in children under the age of 2 years and factors determining ehronic lead exposwe. The aim of this study was to determine hair lead levels and the risk factors of lead poisoning among infants under 2 years of age in istanbul. Lead poisoning in children results from the ingestion of lead in the environ-ment ineluding paint chips, dust, soil, drinking water, consumer produets, enamel utensüs and traditional medicines and usually oecur between the second and third year of life. Lead İs normally present in the hair of healthy subjects, but its concentration varies widely depending on diet and environment. The levels of lead İn hair reflect a long term or past exposure averaging their extent during the perİod of theİr growth. Since hair is readily available and easy to obtain, hair lead nıeasurements may provide a simple tool for sereening. Using a longitudinal design in this study, we obtaincd repeated measures of hair lead levels. A questionnaire was applied to each care giver to identify risk factors for lead exposure. This study was con-dueted at the " Well-Cİıild Unit" based in the istanbul Faculty of Medicine. The families of 199 infants ga-ve their consent for this study. Written consent was obtaİned from care givers of the children. Inclusion criteria for the study were as follows: an uneventfui pregnaney; healthy term infants; birth weight of at ie-ast 2500 g wİth no apparent congenital defeets. Hair samples were colleeted when the infants were aged 1, 6, 12 and 24 months. Ali samples were assessed using atomic absorption speclrophotometer (Varian speetra AA 200, GTA-100). There were 199 infants at the beginning of the study. 193 were left at 6 months, 185 at 12 months and at the end of the study there were İ3I remaining. Hair lead levels inerea-sed by age. Hair lead levels were 2+ 1.6 İn the fİrst month, 3.4+3.0 at 6. month, 4.3+ 3.8 at 12. month, 5.3+ 3.4ug/g at 24. months of age. There were statistically significant dfferences between months (p<0.001). Children who were given herbal teas and who were exposed to smoking environment, and li-ved İn centrally heated homes, and whose fathers were manual workers had significantly high hair lead levels. Our findings suggest that hair lead levels may be a useful parameter to show ehronic lead exposurc and al-so our findings carry some messages for public health nıeasurements such as the nced for avoiding the use of herbal teas and, avoiding passive smoking for the sake of children less than two years of age. Parents and parents-to-be should perhaps take note of these findings in order to gİve their children a healthy start İn life.
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Abstract (Original Language): 
Araştırmamızın amacı 2 yaşından küçük sağlıklı çocuklar arasında saç kurşun düzeylerini ölçmek ve çocukların kronik kurşunla karşılaşma nedenlerini saptamaktır. Kurşun normalde saçta bulunmaktadır. Beslenme, çevresel şartlar nedeniyle miktarı değişebilir. Saçtaki kurşun konsantrasyonu uzun süreli kurşuna maruz kalmanın bir göstergesidir. Saç kolaylıkla uzayıp ve kolayca çocuklardan kolaylıkla alınabileceği için uzun süreli kurşuna maruz kalma ile ilgili toplumsal çalışmalarda veri olarak kullanılabilir. Çalışma prospektif yöntemle İstanbul Tıp Fakültesi Çocuk Sağlığı vc Hastalıkları Ana Bilim Dalı Sağlam Çocuk Polikliniğine Mart 1998 ile Eylül 2000 yıllan arasında başvuran çocuklar arasından yürütüldü. Olgular doğum tartısı 2500g üzerinde, miyadında doğmuş, kronik bir hastalığı olmayan, ailesi bir yıkhr İstanbul'da aynı adreste oturan çocuklardı. Bu çocukların ailelerine sosyo-ekonomik, demografik ve çocukların beslenme bilgilerini almak için 18 soruluk anket uygulandı. İlk başvuran 199, ö.ayda 193, 12 ayda 185, 24 ayda 131, çocuktan alman saç örneklerinde kurşun düzeyleri Atomik Absorbsiyon Spektrofotometresinin Grafit Fırın Ünitesinde (Varİan speetra AA 200, GTA-100) çalışılarak değerlendirildi.. Saç kurşun düzeyinin yaşla birlikte arttığı saptandı. Saç kurşun düzeyleri 1 ay 2± 1.6, 6. ay 3.4+3.00, 12. ay 4.3± 3.8, 24 ay 5.3± 3.4ug/gr İdi. Bu fark istatistiksel açıdan anlamlı idi (p<0.001). Bitkisel çay verilen (ıhlamur, rezene, anason, nane vb), sigara dumanına maruz kalan, kaloriferli evlerde yaşayan çocukların saç kurşun düzeyi yüksek bulundu. Baba mesleğine göre saç kurşun düzeyinde farklılıkların olduğu saptandı.
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  • 4
238-246
  • Turkish

REFERENCES

References: 

1. WHO. Inorganic Lead. In: Environmcntal Health Criteria 165. World Health Organization Gcneva, Sayfa: 25-31(1995).
2. Haan MN, Gerason M: Identification of children at risk for lead poisoning: An evaluation of routine pediatric blood İead sereening in an I1MO- insured popuiation. Pc-diatrics, 6:125 (1995).
3. Tong S, Yasmin E: Environmenial lead exposure: A pub¬lic heallh problem of global dimension. Bıdletin of the World Health Organisalion, 78: 1068 (2000).
4. Al-saleh I, Mustafa A, Dufour L, Taylor A, Hiton R: Lead cxposnre İn the cîty of Arar, Saudİa Arabîa. Ardı En-viron Heaİth, 51: 73 (1996)
5. Jones TM, Moore WL, Craig AS, Rcason RL, Schaffner W: Hidden Threats: Lead poisoning from uııusual sour-ces. Pediatrics, 104 :1223 (1999).
6. Sanbom MD, Abelson A, Campbell M, Weir E: Identif-ying and managing adverse environmental health ef-fecis:3. lead exposure. CMAJ, 166:1287 (2002).
7. Bellinger D, Leviton A, Waternaux C: Longitudinal analyses of prenalat and nostnatal lead exposurc and carly cognitive deveiopmcnt. N Engl J Med, 316:1037 (1987).
8. Schwartz J: Low-Iead lcvcİs exposure and childrcn's IQ: A Meta-analysis and search for a threshold. Enviıron. Res, 65:42(1994).
Özden T.A., İşsever H., Gökçay G., Saner G.
9. Murp DR, Levy B, Levy BS: Pmiccting children from lead poisoning and buitding healthy communities. Am J Pub Health, 89:822(1999).
ÎO. Tong S, Baghıms PA, Sawyer MG, Burns J, McMichael AJ: Declining biood lead levels and changes in cognilivc funcîion during chüdhood. JAMA, 280 : 1915 (1998).
11. Soong WT, Cbao KY, Jang CS, Wang JD: Long- term effect of inereased lead absorplion on in telli gence of children. Arch. Env Health, 54: 297 (1999).
12. Baghurst PA, Mc Michacl AJ, Wigg NR: Environmental exposure to lead and children's intelligence at the age of seven years. The Port Pirie Cohort Study. N Engl J Med, 327:1308(1992).
13. Committe on Environment Hazards. Statement on chüdhood lead poisoning. Pediatrics, 79:457 (1987).
14. American Academy of Pediatrics, Commillcc on Environmental Health, Sereening for Eievaîed Blood Lead Levels. Pediatrics, 101:1072 (1998).
15. Schaffer SJ, Szilagyi PG, Wciîzman M: Lead poisoning risk determination in an urban populalion fhrough the use of a standardizcd queslionnaire. Pediatrics, 93:159 (1994).
16. Binns HJ, LeBailly SA, Fingar AR, Saunders S: Evalua-tion of risk assessment question uscd to targel blood lead sereening in Illinois. Pediatrics, 103:100 (1999).
17. Lanphear BP, Byrd RS, Auinger MS ve ark. Community c haraç teri stic s associated with elevated bîood lead levels in children. Pedialrics.l 0:264 (1998).
18. Göker Ş, Aydın A: İstanbul'un çeşitli semtlerinde oturan çocuklarda kan kurşun düzeyleri ve bu düzeylere etki eden risk faktörleri. Türk Pediatri arşivi., 35:15 (2000).
19. Ermiş H, Çizmecioğlu F, Berkman S and Güray Ö: Anne sütü ve umblikai kordon katımda kurşun düzeyi araştırması. İst. Tıp. Fak Mecmuası, 57: 22 (1994).
20. Onağ A, Taneli B: Toxicity of lead -related environmental factors and other traee and toxic elements in nutrition and health, Proceedings of tbe l'ourth interaational Con-ference on Health and Disease: Effect of Essential and Toxic Tracc elements, New Delhi, 92:176 (1993).
21. Bostancı j, Beyazova U, Kılıç Z ve ark: Kord kam kurşun düzeyi ve prenatal etkilenmenin erken çocuklukta zihinsel fonksiyonlara etkisi. XXXI. Türk Pediatri Kongresi; özel Formu, Ekim-1995, İstanbul.
22. Vural N, Kumbur H, Gülvendik G: Blood Lead levels of occupationally and monoccupationaliy exposcd populalion in Mersin. Health Sci., 2:71 (1990).
23. Gülvendik G, Vural N, Kumbur H: The Conıparison of blood lead levels of the poplatîorts living in Mersiıı( İçel) and Ankara. Precedings of the thiıd Internatİonai Cong-ress on Trace elements in Health and Disease at Adana Turkey); In Trace-89. 523 (1989).
24. Güray Ö, Spor Y, Demir L ve ark.: Metropolitan bir kentte egzos gazlarının mesleksel etkisi (Polis mesleğine iüşkiıı psikososyal ve laboratuvar araştırması) XXI. Ulusal Psikiyatri ve Nöroloji Kongresi Kitabı, Mersin, 249-51(1985).
25. Güray Ö: Ankarada profesyonel kurşun zehirlenmeleri üzerinde bir çalışma. A.Ü.Tıp Fak. Mec, 47:442 (İ984).
26. Güray Ö, Demir L, Hapçıoğlu B: İstanbul 8-12 yaş grubu çocuklrda kurşun zehirlenmesi tehlikesi üzerinde bir araştırma. İ.Ü. Tıp Fak. Mecmuası, 47:442 (1984).
27. Özek E, Bilgen H, ince Z, Yalçınkya A, Bekiroğlu N and Başaran M: Cord blood lead levels sn newborn. Turkisb J.Md Sci, 26:37(1996).
28. Özden TA, Kılıç A, Vehid HV, Toparlak D, Gökçay G, Saner G: Blood Lead levels in school children. lndoor Built and Environment, 12: 1-6 (2003) (In press).
29. Furman A, Laleli M: Semi- Occupational Exposnre to Lead: A case study of Child and Adolescenl slreet ven-dors in İstanbul. Environ. Research Section A, 83:41
(2000) .
30. Tuthill RW: Hair lead levels related to children's classro-om attendon-deficİl behavior. Arch Env Health, 51: 214
(1996) .
31. Kapito L, Byers RK, Shwachman H: Lead in hair of children with ehronic lead poisoning. N Engl J Med, 276: 949(1967).
32. Wilhelm M, Pesch A, Rostek U, Begerow J, Schmitz N, İdel H, Ranft U: Concentrations of lead in blood, hair and saliva of German children living in three diffeıent areas of traffic density. Sci Total Environ, 297:109 (2002).
33. Schumacher M, Belles M, Rico A, Domingo JL, Corbei-la J: Impact of reductioıı of lead in gasoline on the blood and hair lead levels in populalion of Tarragona province, Spain 1990-1995. Sci Total Environ, 184: 203 (1996).
34. Wilhelm M, Idel H: Hair anaiysis in environmenial me-ılicine. Zentralbİ Hyg Urmveltmed, 198:485 (1996).
35. Sen J, Das Chaudhurİ AB, Brief communication of was-hing method of hair samples for tracc element anaiysis in environmental studies. Am J Phs Anthropool, 115:289
(2001) .
36. Brodie K.Routh M: Trace anaiysis lead in blood, alumi-nium and manganase in serum and ehromium in urinc by Graphite Furnace AAS, Clin Bioeem, (17) Sayfa:19 (1984).
37. Glantz Stanton A.: Primer of Biostatistics. Fouılh Editi-on. Mc Graw -Hill. Companies. Inc. USA, 346 (1997).
38. Özden TA, İşsever H, Gökçay G, Saner G: Longiludinal analyses of blood lead levels and risk factors for lead poisoning in healthy children under tvvo years of age. lndoor Built and Environment, (13)xx-x (2004) In press.
(1997) ,346-350.
39. Lekouch N, Sedki A, Bouhouch S, Nejmcddine A, Pinc-au A, Pihan JC: Trace elemements in children's hair, as related exposure in wastewater spreading I'İeid of Marra-kesh (Morocco) The Science Total Environ, 234: 323 (1999).
40. Chlopicka J, Zachwieja Z, Zagrodzki P, Frydrych J, Slo-taP, Krosniak M: Lead and cadmium in Hair an Blood of children from a highly industrial area in Poland. Biol. Trace Elem Res, 62:229 (1998).
41. Chlopicka J, Zagrodzki P, Zacfıwicja Z, Krosniak M, Folta M: Use of pattern recognition methods in the in-terpretation ol" heavy melal (Lead and Cadmium) in chldren's sealp hair. Analysl, 120:943 (1995).
42. Kasznia_Kocot J, Zachwieja Z, Chlopicka J, Krosniak M: The Content of selceted trace elemnet and heavy me¬tals in the hair of children from Chorzow. Peditr PoI.,71:31 (1996).
43. Zaboıowwska W, Wiercinski J: Determinaton of lead, cadmium, copper and zinc in hair of children from îublin as a test of environmental pollution. Rocz Pansiw Zakl Hig, 47:217 (1996).
44. Rhandİs M, Levallois P: Effect of maternaİ cigarette smoking and aîcohol consumption on blood lead levels of newboms. A J Epidemiol, 145:250 (1997).
0-2 Yaş Arası Çocuklarda Saç Kurşun Düzeyleri ve Kronik Kurşuna Maruz Kalma Nedenleri
45. Chiba M, Masironi R: Toxic and trace elements in tobac¬co and tobacco smoke. Bull Health Organ, 70: 269 (i 992).
46. Nordin J, Rolnİc S, Ehünger E: Lead levels in high- risk and low risk young children in Miıınepolis-St Paul met-ropolilan area. Pediatrics, 3 (4) :I32- 5(1997).
47. Weaver VM: Environmental tobacco smoke exposure in inner-city chidren. Cancer Epidemiol, 5: 135 (1996).
48. WoIfsperger M, Hauser WM, Gossler W, Schlagenhau-fen C: Heavy metals in human hair from Austria and Itaîy: Influcnce of sex and smoking habİts. Sci Total Environ, 156:235(1994).
49. WHO. Inorganİc Lead. In: Environmental Health Criteria 165. World Health Organization Geneva, (1995), Say-fa:33-60.
50. Işıklı B, Demir TA, Berber A, Kalyoncu C; Yol kenarı toprak ve bitkilerinde kurşun bivkimi. VI Ulusal Halk Sağlığı Kongresi Adana, Nisan (1998) Sayfa:4l4.
51. Wİlhelm M, Lombeck I, Hafner D, Ohnesorge FK: Hair lead ievels in yotıng children from The F.R.G. Trace Elem Electroites Health Dis, 3:165 (1989).

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