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FAZLA KİLOLU VE ŞİŞMAN KADINLARDA ÜRİK ASİT DÜZEYLERİ

Journal Name:

  • İstanbul Tıp Fakültesi Dergisi

Publication Year:

  • 2003

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
The serum uric acid levefs in ovenveighf and abese womcn. The aim of this study was to de-terminc the relation belvvccn serum uric acid levels and mctalıolic paraıueters in 2486 overwe-ight and obesc women (body mass index, BMI>25 kg/m2). Serum uric acid levels wcre signif'İ-cantly correlated to BMI (r:.2980), waist circıımference (r:.3ü53), glucose (r: .1 123). maxİ-mum (r:,1629), and minimum blood pressurc (r:.1784), cholesterol (r:.1524), HDL-cholcsteroi (r:-.1051), triglyceridc (r:.1292), insülin (r:.2022) and HOMA (r:.2244; p for alls < 0.001). BMI, waist circıımference, glucose. maxinuım and minimum blood pressure, cholesterol, triglyceridc, insülin and HOMA levels were sİgnificantly lıighcr and HDL- cholesterol icvel was sİgnificantly lower İn the group wi!h elcvated uric acid levels. Our results suggcst thal serum uric acid levels is a convenient metbod to determine the obesity relaled melabolic complicati-ons, i.c. insülin a resisiancc and inereased risk for coronary bcart discasc.
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Abstract (Original Language): 
Bu çalışma fazla kilolu ve şişman kadınlarda ürik asit düzeyleri ile çeşitli kardiyovasküler risk göstergeleri arasındaki İlişkileri araştırmak amacıyla yapıldı. Çalışma kapsamı içine alman 2486 fazla kilolu ve şişman (beden kitle İndeksi, body mass index, BMI>25 kg/m2) kadında ürik asit düzeyleri ile vüeut yağ miktarı, vücut yağ dağılımı vc risk göstergeleri arasında anlamlı ilişkiler saptandı (BMI, r:.2980; bei çevresi, n.3053, glukoz, r: .1123; maksimum damar basıncı, r:.1629; minimum damar basıncı, r:.17S4; kolesterol, r:.1524; HDL-kolcsterol, r:-.105l; triglıserit, r:.1292; hısülin, r:.2Ü22 ve HOMA, r:.2244; tümü için p < O.ÜUI). Bunun yaııısıra ürik asit düzeyi yüksek olanlarda normal olanlara göre damar basıncı, HOMA, trigli-serid, glükoz, ve insülin seviyeleri anlamlı yüksek vc HDL-kolesterol değerleri anlamlı düşük bulundu. Bulgular, yüksek ürik asil düzeylerinin şişmanlarda risk göstergeleri ve insülin direnci varlığını yansıtan bir parametre olabileceğini düşündürmektedir.
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  • 4
229-233
  • Turkish

REFERENCES

References: 

1. Armitage P, Bcıry G: StatiMical Melhocls in Medical Research, Blackwell, Oxford, 2.Babkı, (1987).
2. Basdevaııt A, Cassulo D. Çiibaull T, Raison J, Gtıy-Grand B: Microalbuminuria and body fal distribulion in obese sııbjects. IntJObes 18: 806(11)94).
3. Bcnglsson C, Lapİdus L, Steııdalıal C, Waldenstronı .1: H y perm i cem ia and risk. ol" cardiovascııîar disea.se and
Sertkaya A.Ç., Manlar F., Özbey N., Orhan Y.
ovcrul) death. A 12 year follow-Lip of participitants in Ihc popıılalion stıtdy of women İn Golheııburg, Sweden. Açta Med Scand 224: 549 (1988).
4. Bonom E, Targhcr G, Zencre MB, Saggiani F, Cacciaiori V, Tosi F. Travia D.Zenlİ MG. Branzİ P. Santi L, Mug-geo M: Relalionship of uric acid corıcenlralion to cardio-vascular risk factors in young men. Role of obesity and ecntral fat dislribulion. The Vcrona Young Men Athe-rosclerosis Risk Factors Siudy. Int J Obes 2Ü: 975 (IW6).
5. Brand FEN, McGee DL. Kannel WB. Slokes J III, Cas-lelîi WP: Hyperuricemia as a risk lactor of coronary hc-arl disease. The Framinglıam Sludy. Am J Epidemİo) 121: I i (1975).
6. Bruckerl E, Giral P, Ratziu V, Poynard T, Chapman MJ, Opolon P, Tıııpin G: A constellation ol' cardiova.senlar risk Jaclors is assoeİated \vilh hepatic enzyme elevation in hypcrijpidemic patietıts. Mctaboiism 51:107i (2Ü02).
7. Chıırch TS, Finley CE, Earnest CP. Kampeıl JB, Gib-bons LW, Blair SN: Relalivc associaiions of Hlncss and l'alncss lo fîbrinogen, whilc blood celi coıınl, uric acid and mctaholic syıulrome. Inl J Obes 26: 805 (2002).
8. Dawsoıı-Saunders B, Trapp RG: Basic and CHnical Bios-tatistics. Appletnn & Lange, Coııncclicut, (1994).
9. De Fronzo RA, Tobiıı JD, Andrcs R: Glucose elamp technk]ue. A nıetlıod lor quantifying insülin secreıiun and resisiancc. Am J Physiol 237: E214-E223, 1979.
10. Dcüpres JP: Dyslipidemia and obesity. Baİllicre's Clin Endocrinol Mcıab 8: 629 (1994).
11. Despıes JP, Laıııarche B. Mauriegc P, Cantin B, Dagena-is GR, Moorjani S, Lııpİen PJ: Hyperinsulİncmia ÜS an independenl risk faclor for isehemîc hcart disease. N EugiJ Mcd .114: 952 (1995),
12. Desprcs JP, Pi'ud'honııııe D, Pouliot MC, Tremblay A, Botıchard C: Estimation of dcep abdominal adipose (is-sııe accumulation İroni simple anlhropomelric measurc-menls in inen, Am J Clin Nıılr 54: 471 (1991).
13. Duncan MM, Sirıgh BM, VVİse Pil, Carter G, Ataghband Zadeh J: A simple mcasure ol' insülin resislance, Lanccl 346: 120(1995|.
14. Enzİ G, Busetto L. Carrara R, İnelmen EM, Digilo M, Giantin V. Perini V: Association of mulliple risk factors for cardıovascuiar diseases and visccral obesily. A de-adly qııartet or scMet. Obesity iti Europe 1993, Ed: Dils-clıuneil M el al, John Libbey Co., Londra. (1994), s: 437¬445.
15. Folsom AR, Bııcke GL, Bailew C, Jacobs Jr DR, Haskell WL, Donahuc RP. Liu K, Hüner JE: Relation of body fatııess and its distribııtion lo cardıovascuiar risk factors in young blacks and whiles, The role of insülin. Am J Epidemfol 130: 11 (1989).
16. Geriler MM, Gam SM, Leviııe SA: Serum uric acid in relation to age and physicjue in health and coronary hcart discasc. Atın itileni Med 34:1421 (1951),
17. Gucli N, Del Ne.ro A, Zia N. Carmenini E, Cacciafesla M: An assessmcnl of the main melabolic variables of cardıovascuiar risk in a samplc popıılalion of woıkers in Rome. Panmincrva Med 43: 267 (2001).
18. Johnson RJ, Kang DH, Feig D, Kivlighn S, Kancllis J, Waıanabe S, Tuule KR, Rodıiguezdlurbe B, Hencıa-Acosta J, Maz?ali M: Is ihcre a pallıogcnetic role for
uric acid in hypertension and caıdiovascalar and renal disease'? Hypertension. 41: 1183 (2003).
!9. Houmard JA, Wheeler WS, McCammon MR, Wel! JM. Truitl N, Hamad SF, Holbert D, Israel RG. Barakat HA: An evahıation of waisl lo hip ralio measurement metlıods in relation to lipid and carbofıydrate mctaboiism in men. Int J Obes 15: 181 (1991).
20. Klein R, Klein BE, Coroni JC, Marcady J, Cassell bJC, Tyrobr HA: Senini uric acid. Its relatioııship lo coronary heari disease risk factors and cardıovascuiar disease. Evans Counfy, Georgia. Ardı Inlcrn Med 132: 401 (1973).
21. Lai SW, Li TC. Ng KC: Hyperurİcacmia and its related factors in Taiwaııese middle-aged adults, Int .1 Nıııs Pract. S: 56 (2002).
22. Lakka HM, Lakka TA, Tuomilehto .1, Saİoneıı JT: Abdominal obesily is associated wiıh inereased risk of acnıe coronary events in men. Eur Heart J 23:706 (2002).
23. Lemieux S, Pıud'lıomıne D, Tremblay A, Bouchaıd C, Despıes JP: Anhtropomelric correlates lo changes in vis-ceral adipose lissııe over 7 yenrs in women. Int .1 Obes 20:618 (1966).
24. Lohman T, Roche A, Marlorel R: Siandardardizalion of anthropometric measuremenls. The Airlie (VA) Consen-sus Conference, lîumeıı Kinciics, Champaign, 0988).
25. Matsubara M, Chiba H, Maruoka S, Kalayo.se S: Elcva-led lepıin concenfrations in womcn wilh hyperuricemia. J Atheroscler Thromb 9:28 (2002).
26. Matthews DR, Hoskcr JP, Rudcnski AS, Naylor BA, Tıeaclıer DF, Tuıncr RC: Hcımeoslasis model assess-ment: Insulin resistance and beta-cell funetion from las-ling plasma glucose and insülin concentraiions in man. Dtabelokıgia*2tf:4!2

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