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DETECTION OF DAPSONE RESISTANT MYCOBACTERIUM LEPRAE BY DNA SEQUENCE ANALYSIS FROM A TURKISH RELAPSED LEPROSY PATIENT

Journal Name:

  • İstanbul Tıp Fakültesi Dergisi

Publication Year:

  • 2004

Key Words:

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Mycobacteıium leprae obtained from the relapsed case after 43-year dapsone monolherapy was submİtted to sequence analysis of the genes associated wİth resistance to antileprosy drugs for drag susceptibility testing. Single nucleotide substitutİon was revealcd at the codon 55 of ÛıefolP gene, which had been reported to confer resistance to dapsone. No nıutations in the rpoB and gyrA gcnes indicated thİs isolate was susceptible to rifampicin and fluoroquino-les respecüvely. Drug susceptibility was conducted easily and rapidly by the sequence analysis compared with that by mouse footpad method.
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  • 3
153-156
  • English

REFERENCES

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