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SİSTEMİK LUPUS ERİTEMATOZUS ETYOPATOGENEZİNDE VİRÜSLERİN ROLÜ

THE ROLE OF VIRUSES IN THE ETIOPATHOGENESIS OF SYSTEMIC LUPUS ERYTHEMATOSUS

Journal Name:

  • İstanbul Tıp Fakültesi Dergisi

Publication Year:

  • 2005
Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease characterized by a broad variety of autoantibodies and different clinical presentations. Viruses have long been accused of being one of the potential enviromental triggers of SLE and Epstein Barr virus (EBV) has been the most attractive of these agents based on the evidences obtained from clinical and laboratory studies. Its being ubiquitous in many populations, ability to produce a life-long latent infection and its ability to stimulate the immune system continuously are the features of EBV considered to be consistent with an etiologic role in SLE. In this work, the potential mechanisms of virus-induced autoimmunity and SLE-EBV relationship are reviewed in the context of important papers on this subject.
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Abstract (Original Language): 
Sistemik lupus eritematozus (SLE) çok say›da otoantikor ve farkl› klinik tablolarla karakterize, kronik, inflamatuvar otoimmün bir hastal›kt›r. ‹nfeksiyon ajanlar›ndan virüslerin SLE patogenezinde çevresel tetikleyici etkenler olabilecekleri öne sürülmüfl, kona¤›n immün sistemi ile olan iliflkisi ve flimdiye kadar yap›lan klinik ve laboratuvar çal› flmalarda elde edilen kan›tlar nedeniyle de Epstein Barr virüs (EBV) bu virüslerin en çok ilgi çekeni olmufltur. EBVinfeksiyonunun tüm dünyada yayg›n olmas›, EBV’nin infeksiyondan sonra yaflam boyu konakta varl›¤›n› sürdürebilmesi ve ba¤›fl›kl›k sistemini uyaran sürekli bir kaynak oluflturmas› EBV’nin SLE geliflimi için risk oluflturan özelliklerinden bafll›calar› olarak ileri sürülmektedir. Bu yaz›da virüslerin otoimmünite geliflimindeki rolleri ve SLE-EBV iliflkisi flimdiye kadar yap›lan önemli çal›flmalar ›fl›¤›nda özetlenmifltir
FULL TEXT (PDF): 
PDF icon arastirmax-sistemik-lupus-eritematozus-etyopatogenezinde-viruslerin-rolu.pdf
  • 3
85-91
  • Turkish

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