DISTRIBUTION OF MICROORGANISMS ISOLATED FROM URINARY SYSTEM INFECTIONS AND ANTIBIOTIC SUSCEPTIBILITY OF ESCHERICHIA COLI STRAINS
Journal Name:
- İstanbul Tıp Fakültesi Dergisi
Keywords (Original Language):
| Author Name |
|---|
Abstract (2. Language):
Objective: Urinary tract infections are one of the major health problems in adults and the most frequently encountered
etiological agent is Escherichia coli. Aprogressively increasing resistance to the antimicrobial agents used for
the treatment of urinary system infections is seen for most of the microorganisms causing these infections.
Material and methods: 300 urine specimens that were sent to Turkish Coal Enterprises Microbiology Laboratories,
Ankara, for the evaluation of urinary system infections were included in this study. Bacteriuria and pyuria were
detected by staining of uncentrifuged urine samples with Gram staining technique and counting the leukocytes by
using Thoma chamber. We aimed to determine the in vitro susceptibility of 76 Escherichia coli strains, isolated from
300 urine specimens by disk diffusion test as recommended by Clinical Laboratory Standarts Institute, to aminopenicillin,
aminoglycosides, quinolones, cephalosporins, and to betalactam / beta-lactamase inhibitor combinations.
Results: As a result, no growth was detected in 58% of specimens, significant growth was detected in 25.34%, and
16.66% of specimens were considered as contaminated.
The high resistance rates were detected to ampicillin (50.8%), co-trimoxazole (97.7%), and amoxicillin / clavulanic
acid (69.6%) respectively. The high susceptibility rates were detected to cefepime (98.3%), meropenem
(97.7%), amikacin (95.08%), and netilmicin (95.8%).
Conclusion: According to our findings, quinolones and aminoglycosides seem to be the most effective antibiotics
for the treatment of urinary tract infections.
Bookmark/Search this post with
Abstract (Original Language):
Amaç: Üriner sistem enfeksiyonlar› eriflkinlerde s›k görülen önemli bir sa¤l›k sorunudur ve en s›k rastlanan etkenler
gram negatif basiller olup Escherichia coli ilk s›ray› almaktad›r. Üriner sistem enfeksiyonlar›na yol açan mikroorganizmalar›
n ço¤unda tedavide kullan›lan antimikrobiyal ajanlara artan oranda direnç geliflti¤i görülmektedir.
Bu çal›flmada, Ankara Türkiye Kömür ‹flletmeleri laboratuvar›’na üriner sistem enfeksiyonu ön tan›s› ile gönderilen
toplam 300 idrar örne¤inden izole edilen mikroorganizmalar›n da¤›l›m› ve antimikrobiyallere in-vitro duyarl›-
l›klar›n›n belirlenmesi amaçlanm›flt›r.
Gereç ve yöntem: ‹drar örneklerinden bakteriyüri ve piyüri tespitinde gram boyama ve thoma lam›nda say›m yöntemi
kullan›lm›fl ve kültürde üreyen mikroorganizmalar say› ve türlerine göre de¤erlendirilmifltir. Toplam 300 idrar
örne¤inin 76’s›nda (%25,4) izole edilen E. coli suflu’nun aminopenisilin, betalaktam / beta laktamaz inhibitör kombinasyonlar›,
aminoglikozit, kinolon ve sefalosporin grubu antimikrobiyallere in-vitro duyarl›l›klar›, Clinical Laboratory
Standarts Institute temel al›narak disk diffüzyon yöntemi ile araflt›r›lm›flt›r.
Bulgular: Olgular›n 174’ ünde (%58) üreme olmazken, 76’s›nda (%25,4) anlaml› üreme ve olgular›n 50’sinde
(%16,6) kontaminasyon saptand›. En yüksek direnç saptanan antimikrobiyaller s›ras›yla ampisilin (%50,8), ko-trimaksazol
(%60,65) ve amoksisilin/klavunat (%69,6) bulundu. Sefepim (%98,3), meropenem (%97,7), amikasin (%
95,08) ve netilmisine (%95,8) ise yüksek oranda duyarl›l›k saptanan antimikrobiyaller oldu.
Sonuç: Bu çal›flmaya göre üriner sistem enfeksiyonlar›n›n sa¤alt›m›nda öncelikle kinolon ve aminoglikozid grubu
antibiyotiklerin uygun seçenek oldu¤u görüldü.
FULL TEXT (PDF):
- 1
1-4