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FİBRAT KULLANIMINA BAĞLI RABDOMİYOLİZ GELİŞİMİ İLE İLİŞKİLİ AKUT BÖBREK YETERSİZLİĞİ

ACUTE RENAL FAILURE ASSOCIATED WITH RHABDOMYOLYSIS DUE TO FIBRATE USE

Journal Name:

  • İstanbul Tıp Fakültesi Dergisi

Publication Year:

  • 2011

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Sixty two years old female patient presented to our emergency service with diffuse, muscle pain, nausea and vomiting. Her laboratory investigations showed that urea, creatinine, AST, ALT, creatine kinase and phosphorus were increased. The patient was admilted with the diagnosis of acute renal failure. The patient whose history included diabetes mellitus (DM) type 2 and hypertension has received fenofibrate 200 mg daily for hypertrigliceridemia for two months. Last ten days she has had too much muscle pain. On the basis of the clinical and laboratory examinations, a diagnosis of acute renal failure secondary to fenofibrate-induced rhabdomyolysis was made. Fenofibrate was stopped. Intravenous fluid replacement and bicarbonate therapy were started. Hemodialysis was not needed. She was discharged after the clinical and laboratory findings returned to normal.
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Abstract (Original Language): 
Acil servisimize yaygın kas ağrısı, bulantı, kusma Ģikayetleri ile baĢvuran altmıĢiki yaĢında kadın hastanın yapılan tetkiklerinde üre, kreatinin, aspartat aminotansferaz (AST), alanin aminotransferaz (ALT), kreatinkinaz (CK) değerlerinde yükseklik tespit edildi. Hasta akut böbrek yetersizliği tanısı ile yatırıldı. Diyabetes Mellitus (DM) Tip 2 ve hipertansiyon tanıları olan hasta lipid düĢürücü tedavi amacıyla iki aydır günde 200 mg fenofibrat kullanmaktaydı. Son on gündür belirgin kas ağrıları vardı. Mevcut klinik ve laboratuar bulgularının eĢliğinde hastada fenofibrat kullanımına bağlı rabdomiyolizin sebep olduğu akut böbrek yetersizliği tanısı konuldu. Fenofibrat tedavisi kesildi. Ġntravenöz sıvı tedavisi ve idrarı alkali yapmak amacıyla bikarbonat tedavisi uygulandı. Hastanın takiplerinde diyaliz ihtiyacı olmadı. Fizik muayene ve laboratuvar bulguları geriledi. Hasta poliklinik kontrolüne gelmek üzere çıkarıldı.
FULL TEXT (PDF): 
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  • Turkish

REFERENCES

References: 

1. Bellomo R.The epidemiology of acute renal failure:1975 versus 2005. Curr Opin Crit Care. 2006;12:557- 560.
2. Clouatre Y, Leblanc M, Ouimet D, Pichette V. Fenofibrate induced rhabdomyolysis in two dialysis patients with hypothyroidism. Nephral Dial Transplant 1999;14:1047-1048.
3. Deighan CJ, Wong KM, Mclaughin KJ, Harden P. Rhabdomyolysis and acute renal failure resulting from alcohol and drug abuse. Q J Med 2000;93:29-33.
4. Graham DJ , Staffa JA, Shatin D, Andrade SE, Schech SD, La Grenade L, Gurwitz JH, Chan KA, Goodman MJ, Platt R. Incidence of hospitalized rhabdomyolysis in patients treated with lipid lowering drugs. JAMA 2004 ;292:2585-2590.
5. Melli G, Chaundry V, Cornblath DR.Rhabdomyolysis ;an evaluation of 475 hospitalized patients.Medicine (Baltimore) 2005;84:377-385.
6. Nash K, Hafeez A, Hou S. Hospital acquired renal insufficiency. Am J Kidney Dis. 2002; 39:930-936.
7. Rosenson RS:Current overview of statin induced myopathy. Am J Med 2004;116:408-416.
8. Sauret JM, Marinidess G, Way Gordon K. Rhabdomyolysis. Am Fam Physician 2002;65:907-912.
9. Vanholder M, Sever MS, Erek E, Lameine N, Acute renal failure related to crush syndrome:Toward on area of seismo nephrology? Nephrol Dial Transplant 2000;15:517-521

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