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SİSPLATİN TOKSİSİTESİ: OKSİDATİF STRESİN ÖNEMİ VE ANTİOKSİDANLARIN ETKİSİ

CISPLATIN TOXICITY: IMPORTANCE OF OXIDATIVE STRESS AND EFFECT OF ANTIOXIDANTS

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Abstract (2. Language): 
Cisplatin (CP) is one of the most widely used chemotherapeutic agents for the treatment of several human cancers; however, it has several side effects such as nephrotoxicity, hepatotoxicity, ototoxicity that limits the use of CP. Some studies have shown that CP increases free radical production and thereby oxidative damage. These findings indicate that oxidative stress plays an important role in CP toxicity. On the other hand, many studies have shown the preventive effect of antioxidant agents on CP toxicity. In this review, the importance of oxidative stress in CP toxicity and the preventive role of antioxidants has reviewed.
Abstract (Original Language): 
Sisplatin (CP) çeĢitli kanserlerin tedavisinde yaygın olarak kullanılan kematerapötik ajanlardan biridir, ancak, nefrotoksisisite, hepatotoksisite, ototoksisite gibi çeĢitli kullanımını kısıtlayan yan etkilere sahiptir. Bazı çalıĢmalar, CP uygulaması ile serbest radikal oluĢumunun ve dolayısıyla oksidatif hasarın arttığını göstermiĢtir. Bu bulgular, oksidatif stresin CP toksisitesinde önemli bir rol oynadığına iĢaret etmektedir. Diğer yandan, birçok çalıĢma antioksidan ajanların CP toksisitesini önlenebileceğini göstermiĢtir. Bu derlemede, CP toksisitesinde oksidatif stresin önemi ve antioksidanlar ile CP toksisitesinin önlenmesi ile ilgili çalıĢmalara yer verilmiĢtir.

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Sisplatin toksisitesi

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