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BIOCORAL UYGULANAN KEMİK DEFEKTLERİNDE İYİLEŞMENİN RADYONÜKLİT VE HİSTOPATOLOJİK YÖNTEMLERLE İNCELENMESİ

HEALING EFFECT OF BİOCORAL IN EXPERIMENTALLY PREPARED BONE CAVITIES: Radionuclide and Histopathologic Study

Journal Name:

  • İstanbul Üniversitesi Diş Hekimliği Fakültesi Dergisi

Publication Year:

  • 1993

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Biocoral is a resorbable bone substitute, made from natural coral exoskeleton which İs transformed to resorbable porous Hydroxyapatite form by hydrothermal methods. In this study, effects of this graft material on different stages (1. 2. 3. weeks) of bone healing have been investigated experimentally on an animal model using Tc-99-m-MDP. Absorbed activity by experimentally created bone defects with and without BİOCORAL have been measured with "Gama Counting System". At the same stages of healing period, histopathological examinations were also done. It was found that activity absorbtion in the biocoral implanted group is higher than of the control group. Histopathologic changes at 1st. 2nd. and 3rd. weeks of implantation revealed fast and intensive bone induction in the biocoral group, as compared to control group.
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Abstract (Original Language): 
Eİocoral, mercan eksoİskeletinin hidrotermal yollarla rezorbe olabilen Hidroksiapatite dönüştürülmesiyle elde edilen doğal bir graft materyalidir. Sözkonusu materyalin kemik iyileşmesinin belirli safhalarındaki etkileri hayvan modellerinde deneysel olarak incelendi. Oluşturulan kemik defektlerindeki Tc-99m-MDP tutunumu "Gama Sayıcı Sisteminde" kantitatif olarak incelendi. Biocoral imp-lante edilen kemiklerle kontrol gruplarındaki kemik iyileşmesi, uygulamanın 1.2. ve 3. haftasında his to patolojik olarak incelendi. Çalışmanın sonucunda, deney gruplarındaki aktivite tutunumunun kontrol grubuna göre daha yüksek olduğu bulundu- Histopatolojik incelemelerde ise deney gruplarındaki kemik yapımının kontrol gruplarına göre "iyi" olduğu görüldü.
FULL TEXT (PDF): 
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  • Turkish

REFERENCES

References: 

1. Boyne, P.J.: Possibilities of stimulating bone reconstruction and regeneration by use of graft materrials. In Proceedings of 8th. Int. Conference on Oral Surg. 985: 584-90. Quintesenz Verlag-GMBH BERLIN 1987.
2. Ciark, A.E., Hench, L., Paschall, H.A.: The influence of surface chemistry on implant interface histology. J. Biomed. Mat. Res. 1974 Symp. Materials for Reconstructive Surg. Ciemson Univ.
3. Clinton, M.H., Witcofski, R.: Radiopharmaceuticals for skeletal and renal imaging. In Nuclear Pharmacy. 1986 Clinton-Witcofski, Lea-Febiger Berlin.
4. Guillemin G., Patat, J.L., Fournie, J., Chetail, M.: The use of coral as a bone grafts substitute. J. Biomed. Mater. Res. 1987 21: 557-67.
5. Hench, L.: Bioactive ceramics Ann. New York Acad. Sci. 1988 523:54-71.
6. Hench, L., Paschall, H.A.: Hİsto-chemical responses at abi-omaterials interface. J. Biomed. Master. Res. 1974 5: 49-64.
7. Hench L., Splinter, B.J., Greenlee, T.K., Allen, W.C.: Bonding mechanisms at the interface of ceramic prosthetic materials. /. Biomed. Mat. Res. 1971 2: 117-41.
8. Issahakian, S., Ouhayoun, J., Guillemin, G., Patat, J.L.: Le Coraii Madre'poraire.L'information Dentaire 1987 24: 2123¬32.
9. Klinge, B., Alberius, P., Isaksson, S., Jönsson, J.: Osseous response to implanted natural bone mineral and synthetic HA ceramic in the repair of experimental skull bone defects. J. Oral Maxillofac. Surg. 1992 50: 241-49.
10. Lııyten, F.P., Cunningham, N.S.: Purification and partial amino acid sequence of osteogenin, a protein initiary bone differentiation. J. Biol. Chem. 1989 264: 1377-86.
11. Mac Intyre, D.R., SpecuJand, B.: Autogenous bone grafting for persistent maxillary cyst cavities. Br. Dent. J. 1983 155: 273-77.
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A'. Timoçin, A. Kaynar, S. Öztiirk, A. Sungur, M. Demİryont
12. Mitchell, R.: An evaluation of bone healing in cavities in the jaws implanted with a collagen matrix. Br. J. OralMaxillo-fac. Surg. 1992 30: 180-82.
13. Ouhayoun, J.P., Issahakian, S., Patat, J.L., Guillemin, G., Shabana, A.H.M., Sawaf, H.M., Forest, N.: Histological evaluation of alloplastic grafting İn an animal closed model./. Dent. Res. 1989 4(68)-275 Abs.
14. Ouhayoun, J.P., Issahakian, S., Patat, J.L., Guillemin, G., Shabana, A.H.M., Sawaf, H.M.: Influence of biomaterials on the healing pattern of bony defects in miniature pig mandible. /. Dent. Res. 1989 68: 1244, Special issue.
15. Piotrowski, G., Hench, L., Allen, W„ Miller G.: Mechanical studies of the bone. Bioglass interfacial bond./. Biomed. Mater. Res. 1975 9:47-61.
16. Powers Thomas, A.: Bone imaging. In Nuclear Medicine. Martin Sandler, William-Wilkins London, 1985.
17. Reddi, A.H.: Cell biology and biochemistry of endochondral bone development. Cell. Rel. Res. 1981 1: 209-11.
18. Ripamonti, U.: The induction of bone in osteogenic composites of bone matrix and porous HA replicas./. OralMaxillo-fac. Surg. 1991 49: 817-30.
19.
Timoçin
, N., Oral, C, Soley, S., Olgaç, V.: Banka kemiğinin kemik defekti iyileşmesi üzerine olan etkisinin deneysel olarak araştırılması. İ.Ü. Diş Hek. Fak. Derg. 1992 26(3): 115-18.
20. Urist, M.R.: Bone; Formation by autoinduction. Science 1965 159: 893-99.
21. Vargervik, R".: Critical Sites For New Bone Formation.In Bone Grafts and Bone Substitutes. Habal-Reddi. Saunders Philadelphia, 1992.

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