You are here

Home » Content

D3 HİPERVİTAMİNOZUNUN KEMİKLER VE DİŞLERDE MEYDANA GETİRDİĞİ HİSTOPATOLOJİK DEĞİŞİKLİKLER

HISTOPATHOLOGICAL CHANGES OF BONES AND TEETH DUE TO HYPER VITAMINOSIS OF D3

Journal Name:

  • İstanbul Üniversitesi Diş Hekimliği Fakültesi Dergisi

Publication Year:

  • 1996

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
20 Wistar rats were used in this study, in which the effects oj D} hypervitaminosis on jaws, long bones and teeth were investigated. The rats were divided into four groups, each consisting of five rats. Vitamin D, injection was fei formed in the first group, and propylene glycate (PC) in the second. These rast were fed with normal diet The rats in the third group were fed with a diet rich in vitamin D3. No special application was made in the fourth group, which was used as control. At the end of five weeks Hie rats were sacrified. Paraffin sections of the jaw, incisors, molars and tibias were prepared and examined under light microscope. Bone trabecules and bone marrow were evaluated both in jaws and long, bones. Epiphysial, cartilage was also investigated in the long bones. Dentin tubules, pulp odontoblasts, periodontal and apical reginos of the teeth was examined as well. Histobatolomcal features were compared with those of literature and discussed. In conclusion, the histopathologic changes found tn bone and teeth due to D) hypervitaminosis similar to those of literature.
Bookmark/Search this post with
Abstract (Original Language): 
Ds hipervitaminozunun çene kemikleri, uzun kemikler ve dişle üzerindeki etkilerinin araştırıldığı bu çalışmada 20 Wistar tipi sıçan kullanıldı. Her biri beşer sıçandan oluşan döt grubun ilkine D a vitamini enjeksiyonu, ikincisine prophylene glycol (PC) enjeksiyonu uygulanarak normal dietle beslendi. Üçüncü grup D3 vitamininden zengin dietle beslendi. Kontol grubu olan dördüncü gruba hiçbir uygulama yapılmadı. Beş haftalık deney süresi sonunda öldürülen hayvanların çene kemikleri, Ön ve azı dişleri ile uzun kemiklerinden hazırlanan parafin kesitler ışık mikroskobunda incelendi. Çene kemikleri ve uzun kemiklmerde, kemik trabekülleri, kemik iliği ve uzun kemiklerde epifiz kıkırdağı değerlendirildi. Dişlerde de dentin kanalları, pulpa odontoblasts, periodontal aralık ve apikal bölge araştırıldı. Sonuç olarak dişlerde ve kemiklerde saptanan patolojik değişikliklerin kaynaklar ile uygunluk gösterdiği saptandı.
FULL TEXT (PDF): 
PDF icon arastirmax-d3-hipervitaminozunun-kemikler-dislerde-meydana-getirdigi-histopatolojik-degisiklikler.pdf
  • 2
75
80
  • Turkish

REFERENCES

References: 

1- Harada M, Miyahara T, Miyata M, Komiyama H, Sugu-re A, İkemoto Y, Kondo S, Takamura T, Higuchi S, Otosoma S: Calcium regulating activity of 24a-homo-24, 24-difluoro-1, alpha 25-dihdyroxyvitamin D3 and, 26,27-dimethyl-24, difluoro-1, alpha, 25-dihydroxy-vitamin D3. Calcif-Tissue-Int 1993:5?:318-23
2- HuntRD, Garcia GF, Hegsted DM: Hypervitaminosis D in new world monkays, Am J Oin Nutr 1969:22:358-66.
3- Joffe P, Ladefoged SD, Cintin C, Jensen LT, Hyldstrup L. Acute effect of oral, intrapcitoneai, and intravenous 1 alpha, hydroxychole-calciferol on markers of bone metabolism. Nephrol Dial Transplant 1994:9:524-31.
4- Jenkins GN: The physiology and Biohemistry of the Mouth. Blackwell Sei Pub, Oxford, 1978:16-20.
5- Kent PS, Vawter FG, Dowben MR: Hypervitaminosis D in monkeys; Am J Pathol 1958:54.-37-60.
6- Klein GL, Coburn JW: Total parenteral nutrition and its effect on bone metabolism. Crit Rev Clin Lab Sei 1994:31:135-67.
7- Krishnaswamy K, Theoh PC: Diseases of a Tropical Environment. In: Avery GS, ed, Drug treatment, Pirnciples
and Practice of Clinical Pharmacology and Thrapeutics. :!
Churcil, Livingstone, Edinburgh and London 1980:1187. j
8- Mewberne, PM: Nutritional and metabolic discsacs.
In: benirschke K, Garner FM, Jones TC, eds Pathalogy of la- i
boratory Animals. Vol .1, Spri nger Ve rlag, N ew York 1978. j
9- Pitaru S, Blaushild N, Edelstein S: the effect of toxic
doses of L25-d-Hiydroxycholecalciterol on dental tissues in |Ş
the rat. Archs Oral Biol 1982:27:915-9. t-
10- Reeve J: Therapeutic applications of vitamin D ana- j; logues. Br Med J 1979:2:888-90,
11- Weisman Y, Sapir R, Hareli A, Edeskeain S: Maternal-perinatal interelationsbips of vitamin D metabolism in
rats. Biochim Biophys Acta 1976:428, 388-95. İ
12- Woodard IC, Montgomery CA: Musculoskeletal | system. In: Bcnirsche K, Garner FM, Jones TC, Eds. Patho- [' logy of laboratory Animals. Vol I, Springer Veriag, New York i: 1979:745-6, %
13- Yoshiki S, Yanagisawa T: The role of vitamin D in the !; mineralization of dentin in rats made rachil ic by a diet low in I? calcium and deficient in vitamin D Cak Tiss Res t 1975:25:295-302.

Thank you for copying data from http://www.arastirmax.com