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FARKLI ENDODONTIK YIKAMA SOLÜSYONLARININ TOKSİK VE NEKROTİK DOKU ÇÖZÜCÜ ETKİLERİNİN KARŞILAŞTIRMALI OLARAK İNCELENMESİ

COMPARATIVE INVESTIGATION OF THE TOXIC AND NECROTIC TISSUE-DISSOLVING EFFECTS OF DIFFERENT ENDODONTIC IRRIGANTS

Journal Name:

  • İstanbul Üniversitesi Diş Hekimliği Fakültesi Dergisi

Publication Year:

  • 1998

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
The purpose of this study was to compare the necrotic tissue-dissolving and toxic effects of Cetrexidin and chlorhexidine gluconate with those of two different dilutions (5.25% and 0.5%) of sodium hypochlorite (NaOCI). 5.25% NaOCI and sterile saline were used as positive and negative controls, respectively. In the first part of the study, 0.1 ml of each test solution was injected subcutaneously into predetermined areas on the rabbit dorsum. Test areas were histologically examined 2 hours, 48 hours and 2 weeks after the injections. In the second part, dissolving effect of the inrigants was studied on the necrotic bovine muscular tissue. The results of this study showed that all test solutions exhibited mild inflamation at 2 hours. While 5.25% NaOCI caused the severe inflamatory tissue reactions at 48 hours and 2 weeks, other solutions exhibited moderate inflamation at 48 hours; after 2 weeks, the severity of inflamation was decreased to the mild rate. The fibrosis was observed in all experimental groups except for negative control. 5.25% NaOCI was significantly more effective than 0.5 % NaOCI as a necrotic tissue solvent Necrotic tissue-dissolving effect of Cetrexidin and chlorhexidine gluconate was less effective than 0.5% NaOCI.
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Abstract (Original Language): 
Bu çalışmanın amacı Cetrexidin ve klorheksidin gluko-nat'ı, toksik ve nekrotik doku çözücü etkileri bakımından iki farklı konsantrasyondaki (% 5.25 ve %0.5) sodyum hipoklorit (NaOCI) ile karşılaşürmah olarak incelemektir. Çalışmada %5.25'lik NaOCI pozitif kontrol, serum fizyolojik ise negatif kontrol olarak kullanılmıştır. Çalışmanın birinci bölümünde herbir yıkama solüsyonunun 0.1 ml'si tavşanın sırt bölgesinde daha önce belirlenen bölgelere cilt altı bağ dokusuna enjekte edildi. Enjeksiyon bölgeleri 2 saat, 48 saat ve 2 hafta sonra histopatolojik olarak incelendi ve oluşan doku reaksiyonları değerlendirildi. İkinci bölümde yıkama solüsyonlarının nekrotik sığır kas dokusu üzerindeki çözücü etkileri incelendi. Çalışma sonunda; iki saatlik periyotta tüm solüsyonların hafif yangı oluşturduğu gözlendi. %5.25'lik NaOCI 48 saat ve 2 haftada şiddetli yangısal doku reaksiyonlarına sebeb olurken; diğer test solüsyonlarının 48 saatte orta şiddette yangı oluşturduğu; 2 hafta sonra oluşan yangının en az düzeye gerilediği saptandı, iki haftalık periyotta negatif kontrol dışında tüm deney gruplarında fibrozis gözlendi, %5.25'lik NaOCI'in, %0.5iik NaOCI'e oranla daha etkili bir nekrotik doku çözücü olduğu, Cetrexidin ve klorheksidin glukonaün nekrotik doku çözücü etkisinin %0.5'lik NaOCI'den bile düşük olduğu saptandı.
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REFERENCES

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