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DİŞ ETİ BÜYÜMESİ MEYDANA GETİREN İLAÇLAR VE TEDAVİLERİ

Drug Induced Gingival Overgrowth and Its Management

Journal Name:

  • İstanbul Üniversitesi Diş Hekimliği Fakültesi Dergisi

Publication Year:

  • 2013

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Gingival overgrowth (GO) that associated with phenytoin tharapy was first reported in the dental literature in 1939 by Kimball. Recently, cyclosporine and numerous calcium channel blocker agents have been associated with GO. The etiology of drug-induced GO is not entirely understood but is clearly multifactorial. Some of the risk factors known to contribute to GO include the presence of gingival inflammation, presence of dental plaque, the depth of the periodontal pocket on probing, and the dose and duration of cyclosporine therapy. An oral medicine specialist and a periodontist should monitor patients with GO for as long as they receive therapy with cyclosporine, phenytoin, or calcium channel blockers to evaluate and treat oral complications from medical therapy
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Abstract (Original Language): 
Fenitoin tedavisine bağlı olarak oluşan diş eti büyümesi ilk olarak 1939 yılında Kimball tarafından rapor edilmiştir. Günümüzde, siklosporin ve kalsiyum kanal blokerlerinin diş eti büyümesi ile ilişkili olduğu bilinmektedir. İlaca bağlı diş eti büyümelerinin nedeni tam olarak açığa kavuşturulamasa da, multi-faktöriyel olduğu açıktır. Diş eti enflamasyonu, dental plak varlığı, periodontal cep derinliği, siklosporin tedavisinin dozu ve süresi gibi bazı etkenlerin risk faktörü olduğu ve diş eti büyümesini tetiklediği düşünülmektedir. Diş eti büyümesi olan hastalar, siklosporin, fenitoin veya kalsiyum kanal blokeri tedavisi aldığı sürece, medikal tedaviye bağlı gelişen komplikasyonların değerlendirilmesi ve tedavisi için bir ağız hastalıkları ve periodontoloji uzmanı tarafından izlenmelidirler.
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REFERENCES

References: 

1. Kimball OP. The treatment of epilepsy
with sodium diphenyl hyantoinate, JAMA,
1939; 112: 1244-45.
2. Dongari AI, Langlais RP, McDonnell
HT. Drug-induced gingival overgrowth. Oral
Surg Oral Med Oral Pathol, 1993; 76: 543-
48.
3. Hallmon WW, Rossmann JA. The role
of drugs in the pathogenesis of gingival overgrowth.
A collective review of current concepts.
Periodontol 2000, 1999; 21: 176-96.
4. Katz J, Givol N, Chaushu G, Taicher
S, Shemer J. Vigabatrin- induced gingival
overgrowth. J Clin Periodontol, 1997; 24:
180-82.
5. Barak S, Engelberg I, Hiss Z. Gingival
hyperplasia caused by nifedipine: histopathological
findings. J Periodontol, 1987; 58:
639-42.
6. Nakou M, Kamma JJ, Andronikaki
A, Mitsis F. Subgingival microflora associated
with nifedipine-induced gingival overgrowth.
J Periodontol, 1998; 69: 664-69.
7.Rateitschak-Pluss E, Hefti A, Lortscher
R, Thiel G. Initial observation that cyclosporin-
A induces gingival enlargement in man.
J Clin Periodontol, 1983; 10: 237-46.
8.Thomas DW, Newcombe RG, Osborne
GR. Risk factors in the development of cyclosporine-
induced gingival overgrowth.
Transplantation, 2000; 69: 522-26.
9.Anderson HH, Rapley JW, Williams
DR. Gingival overgrowth with valproic acid:
a case report. ASDC J Dent Child, 1997;
64(4): 294-97.
Diş Eti Büyümesi Meydana Getiren İlaçlar ve Tedavileri
72
10. Ellis JS, Seymour RA, Steele JG,
Robertson P, Butler TJ, Thomason JM.
Prevalence of gingival overgrowth induced
by calcium channel blockers: a community
based study. J Periodontol, 1999; 70: 63-67.
11. Boltchi FE, Rees TD, Iacopino AM.
Cyclosporine a-induced gingival overgrowth:
a comprehensive review. Quintessence Int,
1999; 30: 775-83.
12. Armitage GC. Development of a classification
system for periodontal diseases and
conditions. Ann Periodontol, 1999; 4: 1-6.
13. Fattore L, Stablein M, Bredfelt G,
et al. Gingival hyperplasia: a side effect of
nifedipine and diltiazem. Spec Care Dent,
1991; 11: 107-09.
14. Myers BD, Newton L. Cyclosporineinduced
chronic nephropathy: an obliterative
microvascular renal injury. J Am Soc
Nephrol, 1991; 2(1): 45-52.
15. Dongari-Bagtzoglou A, Research
Science and Therapy Committee, American
Academy of Periodontology. Drug-associated
gingival enlargement. Informational
paper. J Periodontol, 2004; 75(10): 1424-31.
16. Butler RT, Kalkwarf KL, Kadhal WB.
Drug-induced gingival hyperplasia: phenytoin,
cyclosporine and nifedipine. JADA, 1987;
114: 55-60.
17. Ciancio S, Bartz N, Lauciello F. Cyclosporine-
induced gingival hyperplasia and
chlorhexidine: a case report. Int J Periodontics
Restorative Dent, 1991; 11: 241-45.
18. Hernandez G, Arriba L, Lucas M,
Andres A. Reduction of severe gingival
overgrowth in a kidney transplant patient
by replacing cyclosporin a with tacrolimus.
J Periodontol, 2000; 71: 1630-36.
19. İlgenli T, Atilla G, Baylas H. Effectiveness
of periodontal therapy in patients
with drug-induced gingival overgrowth.
Long term results. J Periodontol, 1999; 70:
967-72.
20. James JA, Jamal S, Hull PS, Macfarlane
TV, Campbell BA, Johnson RWG,
Short CG: Tacrolimus is not associated with
gingival overgrowth in renal transplant patients.
J Clin Periodontol, 2001; 28: 848-52.
21. Kantarcı A, Cebeci İ, Tuncer Ö, Çarın
M, Fıratlı E. Clinical effects of periodontal
therapy on the severity of cyclosporin: ainduced
gingival hyperplasia. J Periodontol,
1999; 70: 587-93.
22. Wong W, Hodge MG, Lewis A, Sharpstone
P, Kingswood JC. Resolution of cyclosporin-
induced gingival hypertrophy with
metronidazole. The Lancet, 1994; 343: 86.
23. Seymour RA, Smith DG, Rogers SR.
The comparative effects of azathioprine and
cyclosporin on some gingival health parameters
of renal transplant patients. J Clin Periodontol,
1987; 14: 610-13.
24. Pick RM, Colvard MD. Current status
of lasers in soft tissue dental surgery. Review.
J Periodontol, 1993; 64: 589-602.
25. Seymour RA, Smith DG. The effect
of a plaque control programme on the incidence
and severity of cyclosporin-induced
gingival changes. J Clin Periodontol, 1991;
18: 107-10.

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