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Bazı Bitki Ekstrelerinin Propionibacterium acnes Üzerine Antibakteriyel Etkilerinin Araştırılması

Investigation of the Antibacterial Effects of Some Plant Extracts on Propionibacterium acnes

Journal Name:

  • Kahramanmaraş Sütçü İmam Üniversitesi Doğa Bilimleri Dergisi

Publication Year:

  • 2012

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Acne vulgaris (Acne) is a disease of the sebaceous glands, and especially affects the facial region. In this study, Matricaria chamomilla (chamomile), Alchemilla vulgaris (lady's mantle), Lavandula angustufolia (lavender), Melissa officinalis (melissa), Fumaria officinalis (fumeterre) and Punica granatum (pomegranate) bark extract’s antibacterial activity were determined against 6 different strains of Propionibacterium acnes. Plant extracts concentrations in the 2 mg/ml and 5 mg/ml used in our study were observed antibacterial activity against clinical P. acnes strains, which used in this study, and 0.5 mg/ml concentration of the plant extract showed no antibacterial activity. 5 mg/ml concentration is prevent reproduction (antibacterial activity) 100%, 2 mg/ml plant extracts concentration prevent reproduction 100%, excluding extract of Matricaria chamomilla and bark extract of Punica granatum. As a result of this study, a new effective herbal based preparations, which will developed, may have the potential both to become an alternative and to support classical acne treatment, is identified.
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Abstract (Original Language): 
Acne vulgaris (Akne) yağ bezlerinin bir hastalığıdır ve özellikle yüz bölgesini etkilemektedir. Bu çalışmada, Matricaria chamomilla (papatya), Alchemilla vulgaris (aslanpençesi), Lavandula angustufolia (lavanta), Melissa officinalis (melissa), Fumaria officinalis (şahtere) ve Punica granatum (nar) kabuğu ekstrelerinin, 6 farklı Propionibacterium acnes suşuna karşı antibakteriyel aktiviteleri belirlenmiştir. Kullanılan bitki ekstrelerinin 2 mg/ml ve 5 mg/ml konsantrasyonları çalışmamızda kullanılan klinik P. acnes suşlarına karşı antibakteriyel aktivite gösterdiği gözlenmiş, 0,5 mg/ml konsantrasyonundaki bitki ekstresi ise antibakteriyel aktivite göstermemiştir. 5 mg/ml konsantrasyonda üreme %100 önlenmiş (antibakteriyel aktivite), 2 mg/ml konsantrasyonda ise Matricaria chamomilla ekstresinin ve Punica granatum kabuğu ekstresi hariç diğer bitki ekstreleri üremeyi %100 önlemiştir. Araştırma sonucunda, yeni geliştirilecek etkili bitkisel kökenli preparatların klasik akne tedavisine hem destek hem de alternatif olma potansiyeline sahip olabileceği tespit edilmiştir.
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  • 1
7-12
  • Turkish

REFERENCES

References: 

Abascal K., Yarnell E. 2002. Herbs and Drug
Resistance. Potential of Botanical in Drug-Resistant
Microbes. Alternative and Complementary
Therapies 8(4): 237-241.
Adawiyah J., Priya G., Roshidah B. 2010. Oral
Antibiotics in Acne Vulgaris: Therapeutic Response
Over 5 Years. Malaysian Family Physician 5(3):
130-133.
Antoniou C., Dessinioti C., Stratigos A.J., Katsambas
A.D. 2009. Clinical and Therapeutic Approach to
Childhood Acne: An Update. Pediatric Dermatology
26(4) : 373–380.
Bojar R., Holland K. 2004. Acne and propionibacterium
acnes. Clinics in Dermatology 22(5) : 375–379.
Cheung Y. F., Fung C., Walsh C. 1975. Stereochemistry
of Propionyl Coenzyme A and Pyruvate
Carboxylations Catalyzed by Transcarboxylase.
Biochemistry 14(13) :2981-2986.
Degitz K., Ochsendorf F. 2008. Acne
Current Pathophysiologic Considerations. Der
Hautarzt 59(6) : 503-512, DOI: 10.1007/s00105-
008-1497-z
Dorman H. J. D., Deans S. G. 2000. Antimicrobial
Agents from Plants: Antibacterial Activity of Plant
Volatile Oils. Journal of Applied Microbiology 88:
308–316.
Ergin Ç., Ergin Ş., Kaleli İ., Şengül M., Erdoğan B. Ş.
2007. Akne Vulgaris Hastalarında Antibiyotik
Dirençli “Propionibacterium Acnes” Varlığının
Araştırılması. Türkderm 41: 19–21.
Ergin Ç., Kaleli İ., Şahin R., Ergin Ş., Kaçar N. 2006.
Akne Vulgaris Hastalarından İzole Edilen
“Propionibacterium Acnes” Suşlarının
Biyotiplendirilmesi. Mikrobiyoloji Bülteni 40: 15–
21.
Fabricant, D.S., Farnsworth, N.R., 2001. The Value of
Plants Used in Traditional Medicine for Drug
Discovery. Environmental Health, 109(Supp 1) : 69-
75.
Farrar MD, Ingham E. 2004. Acne : Inflammation. Clin.
Dermatol. 22(5): 380-384.
Gürün M. S. 2004. Bitkisel Tıp. Ankem Derg. 18(2):
133–136.
Iinuma K., Noguchi N., Nakaminami H., Sasatsu M.,
Nishijima S., Tsuboi I. 2011. Susceptibility of
Propionibacterium Acnes İsolated From Patients
With Acne Vulgaris to Zinc Ascorbate and
Antibiotics. Clinical, Cosmetic and Investigational
Dermatology 4: 161-165.
Jousimies-Somer H. R., Summanen, P., Citron, D. M.,
Baron, E., Wexler, H. M. Finegold, S. M. 2002.
Wadsworth– KTL Anaerobic Bacteriology Manual.
6th Ed. Star Publishing Co., Belmont, CA.
Kalemba D., Kunicka A. 2003. Antibacterial and
Antifungal Properties of Essential Oils. Current
Medicinal Chemistry 10: 813–829.
Kılıç A. 2008. Uçucu Yağ Elde Etme Yöntemleri.
Bartın Orman Fak. Dergisi 10(13) : 37–45.
Koneman E.W., Allen S.D., Janda W.M.,
Schereckenberger B.C., Winn W.C. 2006.
Koneman's Color Atlas and Textbook of Diagnostic
Microbiology (Color Atlas & Textbook of
Diagnostic Microbiology). Lippincott Williams &
Wilkins Pub J.H. Philadelphia, Lippincot, 1535 pp,
Lood R., Collin M. 2011. Characterization and Genome
Sequencing of Two Propionibacterium acnes
Phages Displaying Pseudolysogeny. BMC Genomics
12: 198.
Monroe S., Polk R. 2000. Antimicrobial Use and
Bacterial Resistance. Curr Opin Microbiol. 3: 496–
501.
Nakatsuji T., Tang D. C., Zhang L., Gallo R. L., Huang
C.M. 2011. Propionibacterium acnes CAMP Factor
and Host Acid Sphingomyelinase Contribute to
Bacterial Virulence: Potential Targets for
Inflammatory Acne Treatment. PLoS One 12; 6 (4) :
e14797. Ramos-e-Silva M., Carneiro S. C. 2009. Acne Vulgaris:
Review and Guidelines. Dermatol Nurs. 21(2): 63–
68.
Simpson N., Cunliffe W. 2004. Rook’s Textbook of
Dermatology. Oxford, Blackwell Publishing, 2123–
2197.
Toroğlu S., Çenet M. 2006. Tedavi Amaçlı Kullanılan
Bazı Bitkilerin Kullanım Alanları ve Antimikrobiyal
Aktivitelerinin Belirlenmesi İçin Kullanılan
Metodlar. KSÜ Fen ve Mühendislik Dergisi, 9(2):
12–20.
Zaenglein A., Graber E., Thiboutot D., Strauss J. 2008.
Fitapatrick’s Dermatology in General Medicine.
New York, McGraw Hill Co. 690–703.
Zandi S., Vares B., Abdollahi H. 2011. Determination
of Microbial Agents of Acne Vulgaris and
Propionibacterium acnes Antibiotic Resistance in
Patients Referred to Dermatology Clinics in
Kerman, Iran. Jundishapur Journal of Microbiology
4(1) :17-22.
Zu Y., Yu H., Liang L., Fu Y., Efferth T., Liu X., Wu
N. 2010. Activities of Ten Essential Oils Towards
Propionibacterium acnes and PC-3, A-549 and
MCF-7 Cancer Cells. Molecules 15, 3200–3210.

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