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HaşhimotoTiroiditli Olguların Klinik ve Laboratuvar Bulgularının Değerlendirilmesi

Evaluation of clinical and laboratory findings in patients with Hashimoto thyroiditis

Journal Name:

  • Online Türk Sağlık Bilimleri Dergisi

Publication Year:

  • 2016

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Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Hashimoto thyroiditis (HT) is a common autoimmune thyroid disorder with a high prevalence in our region. In our article, we presented the clinical and laboratory results of patients with Hasthimoto thyroidits. There were 211 patients diagnosed with HT among internal medicine outpatients from April 2015-January 2016. Clinical, laboratory and thyroid ultrasonography characteristics of these patients were evaluated. Patients were divided into three groups according to their thyoid function: euthyroid(n=169), hypothyroid(n=32) and hyperthyroid(n=10) . Laboratory and several clinical characteristics were compared among groups. Statistical significance was accepted as P< 0.05. HT diagnosis was made in 211 patients. Mean age was 39.31 ± 11.44. Women comprised 92% of the patients. Most patients(72%) had diffuse guatre whereas 16% had nodular and 12% had multinodular pattern. 93.4% of the patients had vitamin D deficiency whereas B12 deficiency was detected in 51(24.1%) patients. Anti-TPO and anti TG antiboies were significantly higher in hypothyroid patients compared to euthyroid and hyperthyroid ones(P<0.001 and P =0.030, respectively). One patient in the hyperthyroid group was co-diagnosed with Graves disease. Most of the patients with HT were euthyroid women. Vitamin D and B12 deficiency were common and this may be due to autoimmune etiology. Hypothyroid patients had higher thyroid antibody levels which might have clinical consequences in this patient group. HT and Graves disease might co-exist and we suggest that differential dignosis must be made carefully between Graves disease and HT in thyotoxic stage.
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Abstract (Original Language): 
Haşimototiroiditi (HT) bölgemizde yüksek prevalansa sahip yaygın bir otoimmüntiroid hastalığıdır. Bu çalışmada HT tanısı konan hastaların klinik ve laboratuvar sonuçlarını sunduk. Çalışmada İç hastalıkları polikliniklerinde Nisan 2015-Ocak 2016 HT’i tanısı konmuş 211 hasta vardı. Bu hastaların klinik, laboratuvar ve tiroid ultrasonografi verileri değerlendirildi. Hastalar tiroid fonksiyonlarına göre ötiroid(n=169), hipotiroid(n=32) ve hipertiroid(n=10) olarak üç gruba ayrıldı. P< 0.05 olan veriler istatiksel olarak anlamlı kabul edildi. Haşimototiroiditli hastalarımızın (n=211) yaş ortalaması 39.31 ± 11.44 idi. Hastaların %92’sini kadınlardan oluşmaktadır. %72’sinin diffüzguvatırı varken, %16’sının nodüler, %12’sinin multinodülerguvatırı vardı. %93.4’ünde D vitamini(25- OHD3) eksikliği varken, 51(%24.1) olguda B12 vitamin eksikliği vardı. Ortalama değerler incelendiğinde hipotiroidik hastalarda hem anti TPO hem anti TG hiper ve ötiroidlere göre anlamlı derecede yüksekti(sırasıyla P<0.001 ve P=0.030). Hipertiroid gruptaki bir hasta Graves Hastalığı ile beraberdi.HT’li hastaların çoğu ötiroid kadındı. Vitamin D ve B12 eksikliği yaygındı ve bu otoimmün etiyolojiye bağlı olabilir. Hipotiroidik hastalar daha yüksek tiroid antikor seviyesine sahipti. HT ve Graves Hastalığı birlikte olabilir ve tirotoksikoz döneminde HT ve Graves Hastalığı ile ayırıcı tanısı dikkatli bir şekilde yapılması önerilir.
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