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Süksinilkoline bağlı fasikülasyon ve kas ağrılarının önlenmesinde iki farklı nondepolarizan ajanın karşılaştırılması

The comparison of two different non-depolarizing relaxants to prevent succinylcholine fasciculations and myalgia.

Journal Name:

  • Selçuk Tıp Dergisi

Publication Year:

  • 2002

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Author NameUniversity of Author
Abstract (2. Language): 
The aim of this study was to compare the effects of rokuronyum and sisatrakuryum pretreatments for preventing succinylcholine-induced fasciculations and postoperatife myalgia. İn this double blind randomised study, 45 ASA I or II between 18-45 years-old scheduled for minör surgery allocated into three groups according to the non-depolarizing pretreatment used. Group 1 (n=15) received normal şaline; group 2 (n=15) received 0.06 mg/kg rocuronium and group 3 (n=15) received 0.015 mg/kg cisatracurium each in the same volume (2 ml) for precurarization. Anaesthesia induced with 1 mg/kg fentanyl and 2.5 mg/kg propofol. Two minutes after precurarization, 1.5 mg/kg succinylcholine was injected and 60 second later the trachea was intubated. Side effects of precurarization, the incidence and magnitude of fasciculations and intubating conditions were evaluated. Myalgias were recorded on postoperatife 48 hours. The incidence and magnitude of fasciculations in group 2 was lower than group 1 and 3. There was no difference in intubating conditions and postoperatife myalgias among the groups. İn conclusion 0.06 mg/kg rocuronium is betler than 0.015 mg/kg cisatracurium to prevent muscular fasciculations following succinylcholine injection vvhen they were given two minutes before succinylcholine. But preteatment with these agents did not reduced the incidence of postoperatife myalgia.
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Abstract (Original Language): 
Bu çalışmanın amacı süksinilkoline bağlı fasikülasyon ve kas ağrılarının önlenmesinde rokuronyum ve sisatrakuryumun etkilerinin karşılaştırılmasıdır. Bu randomize çift kör çalışmada, ASA I veya II grubundan 18-45 yaşları arasında minör cerrahi geçirecek 45 olgu kullanılacak non-depolarizan ajana göre üç gruba ayrıldı. Prekürarizasyon için grup 1 (n=15) 2 ml % 0,9 NaCI, grup 2 (n=15) 2 ml içinde 0,06 mg/kg rokuronyum ve grup 3 (n=15) 2 ml içinde 0,015 mg/kg sisatrakuryum aldı. Anestezi indüksiyonu 1 mg/kg fentanil ve 2,5 mg/kg propofol ile sağlandı. Prekürarizasyon sonrası 2. dakikada 1,5 mg/kg süksinilkolin verildi ve 60 saniye sonra endotrakeal entübasyon yapıldı. Prekürarizasyonun yan etkileri, fasikülasyonların derecesi ve entübasyon koşulları değerlendirdi. Postoperatif 48. saatte kas ağrıları kaydedildi. Fasikülasyon şiddeti ve oranı grup 2'de grup 1 ve 3 e göre daha düşüktü. Entübasyon koşulları ve postoperatif kas ağrıları açısından her üç grup arasında farklılık yoktu. Sonuçta süksinilkolin uygulamasından 2 dakika önce verilen 0,06 mg/kg rokuronyum, süksinilkoline bağlı fasikülasyonların önlenmesinde, 0,015 mg/kg sisatrakuryuma göre daha etkili bulundu. Ancak bu ajanlarla prekürarizasyonun postoperatif kas ağrısı oranlarının azaltmadığı görüldü..
FULL TEXT (PDF): 
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  • 1
33-37
  • Turkish

REFERENCES

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