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Çok düşük (50 Hzj frekanslı manyetik alanın farelerin serum kortizol ve testosteron düzeyleri ile testis histolojisi üzerindeki etkilerinin belirlenmesi

Effects of extremely low frequency [50 Hz) magnetic field on serum Cortisol and testosterone levels and testes histology of the mice

Journal Name:

  • Selçuk Tıp Dergisi

Publication Year:

  • 2006

Key Words:

Keywords (Original Language):

Author NameUniversity of Author
Abstract (2. Language): 
Aim: Since public exposure to extremely low frequency [50 Hz] magnetic fields [ELF-MF) is gradually increasing in industrialized countries, research efforts have focused on the possible effects of the ELF-MF fields on the human health. In this study, it was aimed to find out the effects of ELF-MF at various intensities on serum Cortisol and testosterone levels and to determine histological changes in the testes of the ELF-MF-exposed mice. Material and method: Sixty four mice (Swiss albino mice) obtained from Selçuk University Experimental Medicine Research and Application Center were used in the sudy. The experimental groups were exposed to 50 Hz MF at different intensities [10, 30 and 50 mG) for 40 days. Results: The serum Cortisol levels of the male mice decreased by field effect but in female mice no significant differences were found between control and expo¬sure groups. However, the differences between the control and exposure groups were not significant when the serum Cortisol levels of male and female mice were regarded as a wholes. Serum testosterone level of the 50 mG group was significantly higher than those of the other groups. No significant histological changes were determined in the testes in both control and any exposure groups. Conclusion: There is no direct correlation between the ELF-MF intensity and serum Cortisol and testosterone levels, and ELF-MF does not cause histologi¬cal changes in testes.
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Abstract (Original Language): 
Anaç: Endüstriyel ülkelerde, 50 Hz'lik çok düşük frekanslı manyetik aianiara (ÇDF-MAJ giderek daha fazla maruz kalındığından, bu alanların insan sağlığı üzerindeki olumsuz etkilerinin belirlenmesine yönelik araştırmalar yoğunluk kazanmıştır. Bu çalışmada, farelerde farklı şiddetlerdeki ÇDF-MA'nın serum kortizol ve testosteron düzeylerine etkisinin ve testislerde oluşan histolojik değişikliklerin belirlenmesi amaçlanmıştır. Gereç ve Yöntem: Çalışmada Selçuk Üniversitesi Deneysel Tıp Araştırma ve Uygulama Merkezinden temin edilen 64 fındık faresi {Swiss albino fare) kullanıldı. Uygulama gruplarındaki hayvanlar 40 gün süreyle 50 Hz'lik farklı şiddetlerdeki (10, 30 ve 50 mGJ manyetik alana maruz bırakıldı. Bulgular: Erkek farelerin serum kortizol düzeyleri alan etkisiyle önemli derece düşerken, dişilerin serum kortizol düzeyleri etkilenmedi. Erkek ve dişi farelerin serum kortizol düzeyleri birlikte değerlendirildiğinde, gruplar arasında fark yoktu. Serum testosteron düzeyleri, 50 mG manyetik alana maruz bırakılan erkek hayvanlarda diğer gruplardakinden önemli derecede yüksekti. Hem kontrol grubun¬da hem de çalışma gruplarında testislerde önemli bir histolojik değişikliğe rastlanmadı. Sonuç: Farelerin farklı şiddetlerdeki ÇDF-MA'na maruz bırakılmasıyla serum kortizol ve testosteron düzeyleri arasında doğrusal bir ilişkinin bulunmadığı ve testislerde histolojik değişiklik oluşmadığı sonucuna varıldı.
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