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Diyet yağlarının serum ve beyinde antioksidan aktivite üzerine olan etkileri

Effect of dietary oils on antioxidant activity in the serum and brain

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Abstract (2. Language): 
Aim: In this study, we have aimed to study the effects of most commonly consumed oils, namely olive oil. butter, margarine, soybean oil and sunflower oil on serum and brain antioxidant activity (AOA). Material and method: For this purpose totally 60 Sprague-Dawley rats were divided into five groups. The goups were fed with a diet containing 15% olive oil, butter, margarine, soybean oil and sunflower oil for a period of 2 months. At the end of that period they were decapitated and brains were removed, blood samples were drawn and AOA levels were measured. Results: The brain AOA level of the olive oil group was significantly higher than that of the margarine, sunflower oil and soybean oil groups (p<0.00l J and AOA of the butter group was significantly higher than AOA of the sunflower oil fp<0.01) and the soybean oil [p<0.001) groups. Serum AOA levels of the butter (p<0.00IJ and olive oil (p<0.05) groups were significantly higher than that of the sunflower oil group. Conclusion: As a result, it can be argued that olive oil and butter are the best oils for health in respect to total antioxidant activity.
Abstract (Original Language): 
Amaç: Çalışmamızda toplum tarafından en çok tüketilen yağlar olan zeytin yağı, tereyağı, margarin, soya yağı ve ayçiçekyağının serum ve beyin dokusunda antioksidan aktivite (AOAJ üzerine olan etkisini araştırmayı amaçladık. Gereç ve yöntem: Bu amaçla 60 adet rat alınarak 5 gruba ayrıldı. Gruplar, sırası ile %15 oranında zeytin yağı, tereyağı, margarin, soya yağı ve ayçiçek yağı ilave edilen yem ile 2 ay süre ile beslendi. Bu süre sonunda ratlar dekapite edilerek beyin ve kan örneklen alındı ve AOA düzeyleri ölçüldü. Bulgular: Zeytin yağı grubunun beyin AOA değerlen margarin, ayçiçek ve soya yağı gruplarının fP<0.00l) değerlerinden, tereyağı grubunun değerleri ise ayçiçek (P<0.0IJ ve soya yağı (P<0.00l) gruplarının değerlerinden anlamlı olacak şekilde yüksek bulundu. Zeytin yağı (P<0.05) ve tereyağı [P<0.00l) grubunun serum AOA değerleri ayçiçek yağı grubunun değerlerinden anlamlı derecede yüksekti. Sonuç: Bulgularımızdan yola çıkarak AOA açısından sağlılığımız için en yararlı yağın zeytin yağı ve tereyağı olduğunu söyleyebiliriz.
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REFERENCES

References: 

1. Liao F, Berliner JA, Mehrabian M, Navab M, Demer L, Fogelman AM. Minimally modified low density lipopro¬tein is biologically active in vivo in mice. J Clin Invest 1991;87:2253-7.
2. Kalman J, Kudchodkar BJ, Krlshnamoorthy R, Dory l_ Lacko AG. Agarwal N. High cholesterol diet down regu¬lates the activity of activator protein-1 but not nuclear fac¬tor-kappa B in rabbit brain. Life Sciences 2001;68:1495¬1503.
3. Paivi kleemola. Riitta Freese, Matti Jauiainen, Rajha Pahlman, Georg Alfthan, Marja Mutanen. Dietary determinants of serum paraoxonase activity in healthy humans. Atherosclerosis 2002;160:425-32.
4. Calder PC, Costa Rosa LFBP, Curi R. Effects of feeding lipids of different fatty acid compositions upon rat lymphhocytes proliferation. Life Sci 1995;56:455-63.
5. Akkuş İ. Serbest Radikaller ve Fizyopatolojik Etkileri. Konya: Mimoza Yayıncılık I 995:42-1 23.
6. Harman D. Role of antioxidant nutrients in aging: Overview. Age, 1995;18:51-62.
7. Halliwell B. Current Status Review: Free radicals, reactive oxygen species and human disease: a critical evaluation with special reference to atherosclerosis. Br J Exp Path 1989,70:737-57.
8. Reiter RJ. Oxidative damage in the central nervous system: protection by melatonin. Prog Neurobiol 1998;56:359-84.
9. Preira B, Costa Rosa LFBP, Safi DA Guimaraes ARP, Bechara EJ, Curi R. Antioxidant enzyme activities in the lymphoid organs and muscles of rats fed fatty acids-rich diets subjected to prolonged physical exercise-training. Physiol Behav 1994;6:1049-55.
10. Singh R, Pathak DN. Lipid peroxidation and glutathione peroxidase, glutathione reductase, superoxide dismu-tase, catalase, and glucose-6-phosphate dehydrogenase activities in FeCI3-induced epileptogenic foci in the rat brain. Epilepsia 1990;31:15-26.
11. Chevion S, Berry EM. kitrossky N. Kohen R. Evoluation of plazma low molecular weight antioxidant capacity by cyclic voitammetry. Free Radic Bio! Med 1997;22:411-21.

12. Halliwell B. Reactive oxygen species and central neivous system. J Neurochem. 1992;59:1609-23.
13. Ames BM. Dietary carcinogens and anticarcinogens: oxygen radicals and degenerative diseases. Science 1983;221:1256-63.
14. Leenen R, Roodenburg AJ, Vissers MM, Schuurbiers JA van Putte KP, Wiseman SA et al. Supplementation of plasma with olive oil phenols and extracts: influence on LDL oxidation. J Agric Food Chem 2002;50:1 290-7.
15. Halliwell B. Antioxidants in human health and disease. Annu Rev Nutr 1996;16:33-50.
1 6. Yuan YV, kitts DD and Godin DV. Variations in dietary fat and cholesterol intakes modify antioxidant status of SHR and WKY rats. The Journal of Nutrition 1 998; 1 28:1 620¬30.
1 7. Miller IM, Rice-Evans C. Factors influencing the antioxidant activity determined by the ABTS+ radical cation assay. Free Rad Res 1997;26:195-9.
18. Mehmetoğlu İ. Klinik Biyokimya Laboratuarı el kitabı. Konya: Yelken Basım Yayın 2004,139.
19. Tuck KL and Hayball PJ. Major phenolic compounds in olive oil: metabolism and health effects. J Nutr Biochem 2002;13:636-44.
20. Masella R, Giovannini C. Van R, Di Benedetto R, Coni E. Volpe R. Fraone N and Bucci A. Effects of dietary virgin olive oil phenols on low density lipoprotein oxidation in hyperlipidemic patients.Llpids 2001,36:1 195-202.
21. Visioli F, Bellomo G and Galli C. Free radical-scavenging properties of olive oil polyphenols. Biochem Biophys 1998;247:60-4.
22. De La Puerta R, Ruiz Gutierrez V, Hoult JR. Inhibition of leukocyte 5-lipoxygenase by phenolics from virgin olive oil. Biochem Pharmacol 1999; 57:445-9.
23. Reaven P, Parthasarthy B, Grasse B, Miller E, Steinberg D and Witztum JL. Effects of oleate-rich and linoleate-rich diets on the susceptibility of low density lipoprotein to oxidative modification in mildly hypercholesterolemic subject. J Clin Invest 1993;91:668-76.

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