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MİGRENDE GÖZ KIRPMA REFLEKSİ DEĞİŞİKLİKLERİ

Blink reflex alterations in migraine

Journal Name:

  • Selçuk Tıp Dergisi

Publication Year:

  • 2007

Key Words:

Keywords (Original Language):

Author NameUniversity of Author
Abstract (2. Language): 
Aim: According to the neurovascular theory, stimulation of the trigeminovascular system is the cause of neurogenic inflammation and pain in migraine. The blink reflex that is elicited by supraor¬bital stimulation of trigeminal ophthalmic division is a useful method to study the functioning of trigeminal system. The purpose of this study was to examine the blink reflex in migraine patients. Material and method: In this study, blink reflex latencies were evaluated in 25 migraine patients (average age 34,76±8,23 yrs) and compared to those of 25 healthy controls (average age 35,5±8 yrs). Statistical analysis was performed using unpaired Student t test. Results: Results obtained from migraine patients were as follows; ipsilateral latency component R1:11,22±1,64 msec, ipsilateral latency component R2:31,33±4,12 msec, contralateral latency component R2:33,12±5,18. Results obtained from healthy controls were as follows; ipsilateral latency component R1: 10,21±1,42 msec, ipsilateral latency component R2 31,09±2,4 msec, contralateral latency component R2: 32,31±3,34 msec. Ipsilateral Rl latencies were found to be significantly prolonged than those of the healthy controls. Conclusion: The results might suggest a dysfunction in trigeminal networks in brainstem of migraineurs and support the trigeminovascular theory of migraine.
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Abstract (Original Language): 
Amaç: Migrende nörovasküler teoriye göre ağrı ve nörojenik inflamasyona trigeminovasküler sistem stimulasyonu neden olmaktadır. Göz kırpma refleksi de trigeminal sinir oftalmik dalının supraorbital stimulasyonu ile migrende trigeminal sinir fonksiyonunu değerlendirmede oldukça iyi bir yöntemdir. Bu çalışmada migrenli hastalarda göz kırpma refleksi değişikliklerinin değerlendirilmesi amaçlandı. Gereç ve Yöntem: Bu çalışmaya yaş ortalaması 34,76±8,23 olan 25 migrenli hasta alındı. Migrenli hastalarda göz kırpma refleksi latans değişiklikleri yaş ortalaması 35,5±8 olan 25 nörolojik veya psiki-atrik rahatsızlığı olmayan kontrol grubu ile karşılaştırıldı. Sonuçlar unpaired Student t test ile değerlendirildi. Bulgular: Migrenli hastalarda ipsilateral R1 latansı 11,22±1,64 ms, ipsilateral R2 latansı 31,33±4,12 ms , kontralateral R2 latansı 32,3±3,34 ms bulundu. Kontrol grubunda ipsilater-al R1 latansı 10,21±1,42 ms, ipsilateral R2 latansı 31,09±2,4 ms, kontralateral R2 latansı 32,31±3,34 ms bulundu. Migrenli hastalarda ipsilateral R1 latansı kontrol grubu ile karşılaştırıldığında anlamlı derecede uzun bulundu (p=0,025). Sonuç: Migren patogenezinde beyinsapı ve trigeminovasküler bağlantılarının önemli rol oynadığı bu sonuçlarla desteklenmektedir.
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  • 3
121-125
  • Turkish

REFERENCES

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