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KARDİYOVASKÜLER YAŞLANMA

CARDIOVASCULAR AGING

Journal Name:

  • Selçuk Tıp Dergisi

Publication Year:

  • 2008

Key Words:

Keywords (Original Language):

Author NameUniversity of Author
Abstract (2. Language): 
Aim: Aging is a major process that results in changes in cardiovascular structure and function in eld¬erly people. The aim of this review to summarize the effect of aging on some aspects of cardio-vascular structure and function. Result: Increased arterial stiffness alters afterload and left ventricu¬lar shape. Age related deteriorations in left ventricular structure and functions are impaired ejection reserve, increase in diastolic volume and an altered diastolic filling pattern. Reduction in the num¬ber of myocytes and deterioration of subcellular structure are also remarkable with advanced age. Significant alterations in cardiovascular function during exercise are also demonstrated in elderly people. Conclusion: Significant changes have been noted in the structure and function of the car-diovascular system in older people that are considered to be the result of aging. These changes can be regarded as either adaptive or early preclinical disease, but they occur in the absence of clinical¬ly manifest dysfunction.
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Abstract (Original Language): 
Amaç: Yaşlanma, sağlıklı yaşlılarda görülen kardiyovasküler yapı ve fonksiyon bozukluklarına neden olan önemli bir olaydır. Bu derlemede amacımız kardiyovasküler yapı ve fonksiyonlar üzerine yaşlan¬manın etkisini özetlemektir. Ana bulgular: Arteriyal sertlikte artma sol ventrikül şeklini ve afterloadını artırır. Sol ventrikül yapı ve fonksiyonlarındaki yaşla ilişkili olumsuz değişiklikler, ejeksiyon rezervinde bozulma, diyastolik çapta artış ve diyastolik doluş paternindeki değişiklikleri içerir. Miyosit sayısında azalma ve subsellüler yapılarda bozulma ilerleyen yaşla belirginleşir. Yaşlılarda egzersiz sırasında kardiyovasküler fonksiyonlarda anlamlı değişikler olduğu da gösterilmiştir. Sonuç: Yaşlanma sonucu olduğu düşünülen kardiyovasküler sistemin yapı ve fonksiyonunda önemli değişiklikler gözlenmek¬tedir. Bu değişiklikler ya adaptif yada erken preklinik hastalık sayılabilir, fakat klinik olarak açık dis-fonksiyon yokluğunda da oluşabilir.
FULL TEXT (PDF): 
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  • 4
237-243
  • Turkish

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