You are here

Home » Content

Down Sendromu Olan iki Yenidoğanda Konjenital Lösemi

Congenital Leukemia in Two Newborns with Down Syndrome

Journal Name:

  • Selçuk Tıp Dergisi

Publication Year:

  • 2011

Key Words:

Keywords (Original Language):

Author NameUniversity of Author
Abstract (2. Language): 
Congenital Leukemia is rare disease seen at birth or in the first 4 weeks of life . The incidence of Congenital Leukemia is 1 over 4.7 million live births. Most of the cases are myeloblastic leukemia. Usually symptoms like leukocytosis, petechia, echymosis, cutaneous nodules, hepatosplenomegaly and central nervous system involvement are seen. Two newborns with Down syndrome which were septic at application and diagnosed as congenital leukemia are presented in this article. The early recognition of such cases and finding opportunity to treat before the appearance of secondary complications such as sepsis play an essential role for saving life.
Bookmark/Search this post with
Abstract (Original Language): 
Konjenital lösemi, doğumda veya yaşamın ilk 4 haftasında ortaya çıkan nadir bir hastalıktır. Konjenital löseminin görülme sıklığı 4,7 milyon canlı doğumda 1’dir. Konjenital lösemilerin büyük çoğunluğu akut myeloblastik lösemidir. Genellikle lökositoz, peteşi, ekimoz, kutanöz nodüller, hepatosplenomegali ve santral sinir sistemi tutulumu şeklinde bulgular vermektedir. Bu yazımızda down sendromu olan, sepsis kliniği ile gelen ve yenidoğan döneminde konjenital lösemi tanısı konulan iki olgu sunulmuştur. Bu hastaların erken dönemde tanınması ve sepsis gibi ikincil klinik tablolarının ortaya çıkmadan tedavi şansının yakalanması hayat kurtarıcı rol oynamaktadır.
FULL TEXT (PDF): 
PDF icon arastirmax-down-sendromu-olan-iki-yenidoganda-konjenital-losemi.pdf
  • 1
40-42
  • Turkish

REFERENCES

References: 

1. Bayram İ, İncecik F, Özcan K, Leblebisatan G. Konjenital
lösemi, bir vaka takdimi. Çocuk Sağlığı ve Hastalıkları Dergisi
2004;4:280-2.
2. Dongen JCA, Dalinghaus M, Kron AA, Vries ACH, HeuvelEibrink MM. Successful treatment of congenital acute myeloid
leukemia (AML-M6) in a premature infant. J Pediatr Hematol
Oncol 2009;31:853-4.
3. Narayan S, Sharma S, Chandra J, Kulshreshtha R. Clinico
hematological profile of congenital leukemia. İndian journal of
pediatrics 2004;71: 927-8.
4. Fernandez MC, Weiss B, Atwater S, Shannon K, Matthay KK.
Congenital leukemia successful treatment of a newborn with
t(5;11)(q31;q23). J Pediatr Hematol Oncol 1999;21(2):152-7.
5. Nathan and Oski’s Hematology of infacy and childhood. 7th
edition 2009;5:157-69.
6. Ito M, Nishimaki S, Nakano Y, Tanaka F, Goto H, Yokota S. A
case of fetal leukemia with intracranial hemorrhage and earlyonset jaundice. Arch Gynecol Obstet 2009; 279:599-601.
7. Resnik KS, Brod BB. Leukemia cutis in congenital leukemia:
analysis and review of the world literature with report of an
additional case. Arch Dermatol 1993;129:1301-6.
8. Prakash KP, Rau ATK, Bhat ST, Rau AR. Congenital leukemia
a diagnostic dilemma. Indian J Med Paediatric Oncology
2008;29(4):41-3.
9. Fender AB, Gust A, Wang N, Scott GA, Mercurio MG. Congenital
leukemia cutis. Pediatric Dermatology 2008;25(1):34-7.
10. McCoy JP, Travis SF, Blumstein L, Birdsall PB, Schroeder
K, Overton WR, McMorrow LE, Campbell T, Wineburg M,
Greenbaum BH, Hirsch KH, Donaldson MH. Congenital
leukemia: Report of two cases. Cytometry 1995;22:89-92.
11. Kaneko Y, Shikano T, Maseki N, et al. Clinical characteristics
of infant acute leukemia with or without 11q23 translocations.
Leukemia 1988;2:672-6.
12. Pui C H. Childhood leukemia. N Engl J Med 1995;332:1618-25
13. Weschler J, Grene M, McDevitt MA, et al. Acquired mutations
in GATA1 in the megakaryoblastic leukemia of Down syndrome.
Nat. Genet 2002;32:148-52.
14. Grundy RG, Martinez A, Kompski H, et al. Spontaneous
remission of congenital leukemia: a case for conservative
treatment. J Pediatr Hematol Oncol 2000;22:252-5.
15. Dinulos JG, Hawkins DS, Clark BS et al. Spontaneous remission
of congenital leukemia. J Pediatr 1997;131:176-7.
16. Heerema N A, Arthur D C, Sather H: Cytogenetic features of
infants less than 12 months of age at diagnosis of acute lymphoblastic leukemia. Impact of the 11q 23 break-point outcome. A
report of children cancer group. Blood 1994;83:2274–81.

Thank you for copying data from http://www.arastirmax.com