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Kafa Travma Modelinde Mannitol veya Hipertonik Salin Solüsyonlarının Etkilerinin Karşılaştırılması

Comparison of The Effects of Mannitol or Hypertonic Saline Solutions in Head Trauma Model

Journal Name:

  • Selçuk Tıp Dergisi

Publication Year:

  • 2011

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Abstract (2. Language): 
We aimed to compare the effects of 20 % mannitol, 3 % or 7 % hypertonic saline on hemodynamic parameters, intracranial pressure and electroencephalography in experimental head trauma. Bilateral craniotomy were carried out in the parietal region and standart head trauma was applied for all rabbits. The rabbits were randomly divided into four groups. In group I rabbits were only observed. In group II: 20 % mannitol, in group III: 3 % hypertonic saline and in group IV: 7 % hypertonic saline was administered intravenously to achieve similar osmolar load. Electroencephalography, mean arterial pressure, heart rate, intracranial pressure were recorded before trauma and 5 and 60 minutes after trauma. Increased intracranial pressure was significantly decreased by mannitol, 3 % and 7 % hypertonic saline solutions at the end of study (p<0.05). But intracranial pressure values of mannitol and 7 % hypertonic saline groups were lower than the other groups (p<0.05). The electroencephalography scores decreased after trauma in all groups (p<0.05). At end of the study, 3 % and 7 % hypertonic saline groups had similar electroencephalography scores with pretrauma scores (p>0.05). The mean arterial pressure and heart rates increased after trauma in all groups (p<0.05). Mean arterial pressure values were found lower only in mannitol group at end of the study (p<0.05). Our study showed that when used in intracranial hypertension treatment, 7 % hypertonic saline solution is as effective as mannitol, and preserves hemodynamic parameters, and normalizes traumatic electroencephalography abnormalities better than mannitol.
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Abstract (Original Language): 
Deneysel kafa travmasında, % 20 mannitol, % 3 veya % 7 hipertonik salin solüsyonlarının, hemodinamik parametrelere, intrakraniyal basınca ve elektroensefalografi üzerine olan etkilerini karşılaştırılması amaçlandı. Bütün tavşanlara pariyetal bölgeden bilateral kraniotomi yapılarak standart kafa travması uygulandı. Rastgele 4 gruba ayrılan deneklerden; I. gruba tedavi uygulanmazken, II. gruba % 20’lik mannitol, III. gruba % 3’lük hipertonik salin ve IV. gruba % 7’lik hipertonik salin eşdeğer osmolar yükte intravenöz uygulandı. Travmadan önce, travmadan 5 ve 60 dakika sonra; elektroensefalografi, ortalama arter basıncı, kalp atım hızı ve intrakraniyal basınç kayıtları alındı. Mannitol, % 3 ve % 7’lik hipertonik salin solüsyonları intrakraniyal basınçdaki yükselmeyi çalışmanın sonunda düşürdü (p<0.05). Fakat intrakraniyal basınç değerleri, mannitol ve % 7’lik hipertonik salin gruplarında, diğer gruplardan daha düşüktü (p<0.05). Elektroensefalografi skorları tüm gruplarda travmadan sonra düştü (p<0.05). Çalışma sonunda % 3 ve % 7’lik hipertonik salin grupları, travma öncesine benzer elektroensefalografi skorlarına sahipti (p>0.05). Ortalama arter basınç ve kalp atım hızı, bütün gruplarda travmadan sonra yükseldi (p<0.05). Çalışmanın sonunda, ortalama arter basıncı sadece mannitol grubunda düşük bulundu (p<0.05). Çalışmamız intrakraniyal hipertansiyonun tedavisinde % 7 hipertonik salin solüsyonunun; mannitol kadar etkili olduğunu, mannitole göre hemodinamik parametreleri daha iyi koruduğunu, travmaya bağlı gelişen elektroensefalografi anormalliklerini de daha iyi düzelttiğini gösterdi.
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