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Nazal Polipozis Etiyolojisinde Alerjinin Rolü

The Role of Allergy in Etiology of Nasal Polyposis

Journal Name:

  • Selçuk Tıp Dergisi

Publication Year:

  • 2011

Key Words:

Keywords (Original Language):

Author NameUniversity of Author
Abstract (2. Language): 
The aim of this study was to evaluate the role of allergy in patients with nasal polyposis. The study included 100 patients with nasal polyposis and 50 healthy individuals. The study was approved by the Ethics Committee of the Selcuk University Meram Medical Faculty and written informed consent was obtained in all cases. Patients were divided into 3 groups. The first group consisted of patients with asthma and aspirin intolerance; second group consisted of patients with only asthma, third group consisted of patients have no disease. Polyp size by Physical examination, computed tomography (CT) and endoscopic scores, skin-prick test results, blood total eosinophil count, serum levels of total immunoglobulin E and symptom scores were analyzed in 100 patients with nasal polyposis. The results were compared between patients with nasal polyposis and healthy individuals. Prick test results were positive on 42% (n;42) of the patients and 22% (n;11) of the control group. While serum total IgE values of 45% (n;45) of NP patients were higher than the accepted value, serum eosinophil values of 27% (n;27) of the patients were higher than the accepted values. As serum total IgE values of 30% (n;15) of control group were higher than the accepted value, serum eosinophil values of 12% (n;6) of them were higher than accepted value. The values of the serum total eosinophil count and positive prick test results were higher in patients with nasal polyposis than in healty individuals.This result shows that allergy is a important factor on etiopathogenesis of nasal polyposis.
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Abstract (Original Language): 
Çalışma 100 hasta ve 50 sağlıklı kontrol grubunda yapıldı. Nazal polipozisli (NP) hastalar 3 gruba ayrıldı. 1.grup NP, astım ve asetil salisilik asit intoleransının birlikte görüldüğü hastalar (Samter sendromu), 2.grup NP ve astımı olan hastalar ve 3.grup yalnız NP’li hastalardan oluşuyordu. Yüz hastada fizik muayene ile polip boyutları, bilgisayarlı tomografi (BT) ve endoskopi skorları, deri prick test sonuçları, serum total IgE ve periferik eosinofil değerlerine bakıldı. Sonuçlar nazal polipozisli hastalar ve sağlıklı bireyler arasında karşılaştırıldı. Bulgular: Hasta ve kontrol grubunun prick testi sonuçları incelendiğinde; hasta grubunun %42‘sinde (n;42) pozitif, kontrol grubunda 11 (%22) bireyde prick testi pozitif olarak bulundu. NP’li hastalarda 45 kişide total IgE normal değerden yüksek bulunurken, 27 kişide eozinofil değerleri normalden yüksek idi. Kontrol grubunun %30’unda (n;15) serum total IgE değerleri normal değerden yüksek bulunurken %12’sinde (n;6) serum eozinofil değerleri normal değerden yüksek idi. Sonuç: Serum eozinofil değerlerinin ve prick testi pozitifliğinin nazal polipozisli hastalarda, kontrol grubuna oranla daha yüksek bulunması, nazal polipozisin etiyopatogenezinde alerjinin önemli bir faktör olabileceğini göstermiştir.
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  • 2
59-61
  • Turkish

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