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Psöriyazisli Hastalarda Helikobakter Pylori Enfeksiyonu Sıklığı ve Hastalık Aktivitesi Arasındaki İlişki

Prevalence of Helicobacter pylori Infection in Patients with Psoriasis, Association between Disease Activity and Infection

Journal Name:

  • Selçuk Tıp Dergisi

Publication Year:

  • 2011

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Abstract (2. Language): 
It has been reported different results about the prevalence of Helicobacter pylori infection in patients with psoriasis. In several studies, although the prevalence of Helicobacter pylori was reported to be increased, in some studies it could not be shown same results. In this study, we aimed to evaluate the prevalence of Helicobacter pylori infection and the association between disease activity and infection in patients with psoriasis. A total of 11 (8 male, 3 female) patients with psoriasis and 23 healthy controls (18 male, 5 female) were included in the study. Helicobacter pylori infection was diagnosed with biopsy which was obtained from the antrum and the body of stomach or with urea breath test. Before and after Helicobacter pylori eradication, disease activity was revealed with psoriasis area severity index. Sequential eradication regimen was preferred treatment for helicobacter pylori. Urea breath test was used to evaluate the eradication after the treatment Nine (% 82) of 11 patients with psoriasis had positivity for Helicobacter pylori while 11 subjects (% 47,8) of 23 had positivity for Helicobacter pylori in the control group. After the eradication treatment, Helicobacter pylori were negative in six patients. Four patients returned for follow-up visits and psoriasis area severity index had significantly resolved in only one of them. In conclusion, however the number of patients is so not much, in this study the prevalence of Helicobacter pylori was observed to be more frequent in patients with psoriasis but no association between disease activity and infection was found. Further studies are needed to show the association between disease activity and Helicobacter pylori infection.
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Abstract (Original Language): 
Psöriyazisli hastalarda Helikobakter pylori enfeksiyonu sıklığı ile ilgili farklı sonuçlar bildirilmiştir. Birçok çalışmada sık tespit edilmiş olmasına rağmen, bazılarında ise aynı sonuçlar elde edilmemiştir. Bu çalışmada biz, psöriyazisli hastalarda Helikobakter pylori sıklığını ve hastalık aktivitesi ile enfeksiyon arasındaki ilişkiyi göstermeyi amaçladık. Çalışmaya dispeptik yakınmaları olan, 8 erkek ve 3 kadın olmak üzere toplam 11 psöriyazisli hasta alındı. 18 erkek ve 5 kadın olmak üzere 23 sağlıklı kişi kontrol grubu olarak çalışmaya dahil edildi. Helikobakter pylori enfeksiyonu mide orta kısmı ve antrumdan alınan endoskopik biyopsiler veya üre nefes testi ile tespit edildi. Hasta grubunda, Helikobakter pylori tedavisi öncesi ve sonrası hastalık aktivitesi (psoriasis area severity index: PASI) ile değerlendirildi. Helikobakter pylori eradikayonu için ardışık tedavi rejimi tercih edildi. Eradikasyonu değerlendirmek için üre nefes testi yapıldı. Helikobakter pylori, psöriyazisli 11 hastanın 9'unda pozitif olarak tespit edilirken (% 82), kontrol grubundaki 23 kişiden 11'inde (% 47,8) Helikobakter pylori pozitif olarak tespit edildi. Hasta grubunda, tedavi sonrası 9 hastanın 6'sında Helikobakter pylori negatifleşti. Helikobakter pylori eradikasyonu sonrası, kontrole gelen 4 hastanın sadece birinde anlamlı bir PASI iyileşmesi gözlenirken diğer 3 hastada anlamlı bir düzelme izlenmedi. Sonuç olarak bu çalışmada hasta sayısı az olmakla birlikte, Helikobakter pylori enfeksiyonunun psöriyazisli hastalarda sık olduğu gözlenmiş olup, hastalık aktivitesi arasındaki ilişki gösterilememiştir. H.P ile psöriyazis şiddeti arasındaki ilişkiyi göstermek için ileri çalışmalara ihtiyaç vardır.
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  • 3
131-133
  • Turkish

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