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Sakroiliak Eklem Tutulumu ile Seyreden Alkalen Fosfatazın Normal Olduğu bir Paget Hastası

A Paget Patient with Sacroiliac Joint Involvement and Normal Alkaline Phosphatase Level

Journal Name:

  • Selçuk Tıp Dergisi

Publication Year:

  • 2011

Key Words:

Keywords (Original Language):

Author NameUniversity of Author
Abstract (2. Language): 
Paget's disease Is the most frequent disorder of bone after osteoporosis characterized by excess bone growth due to Increased osteoclast activitly. It Is usually seen In older males. Patients are often asymptomatic but sometimes bone pain, fractures, neurological and hearing problems can be seen. Although the pathogenesis of disease is not clear, genetical factors are thought to play role on pathogenesis. Paget's disease is diagnosed by elevated serum alkaline phosphatase activity and abnormal radiological findings. Bisphosphonates are useful in controlling disease activity. Here, we present a patient admitted to our clinic with severe pelvic and back pain, mimicking sacroiliitis, diagnosed via bone sintigraphy as Paget's disease in contrast to normal alkaline phosphatase levels.
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Abstract (Original Language): 
Paget Hastalığı, artmış osteoklastlk aktlvlte sonrası aşırı kemik yapımıyla karakterize olan ve osteoporozdan sonra ikinci sıklıkta görülen bir kemik hastalığıdır. Genellikle ileri yaştaki erkeklerde görülmektedir. Klinik olarak kemik ağrıları, patolojik kırıklar, nörolojik ve işitsel problemler görülse de hastaların çoğu asemptomatik seyretmektedir. Hastalığın patogenezi tam olarak aydınlatılamamakla beraber genetik faktörlerin rol oynadığı düşünülmektedir. Tanı alkalen fosfataz yüksekliği ve radyolojik bulgular ışığında koyulur. Tedavide bifosfonatlardan büyük oranda fayda görülmektedir. Burada yoğun bel ve kalça ağrısı ile kliniğimize başvuran, alkalen fosfataz değerleri normal sınırlarda seyreden ve sakroiliak eklem tutulumu olan, kemik sintigrafisi bulguları ile Paget hastalığı tanısı koyduğumuz bir olgu takdim edilmiştir.
FULL TEXT (PDF): 
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  • 3
170-172
  • Turkish

REFERENCES

References: 

1. Ankom MA, Shapiro JR. Paget's Disease of Bone (Osteitis Deformans). J Am Gerlatr Soc 1998;46:1025-33.
2. Joseph LS. Paget's disease of bone: a review of epidemiology, pathophysiology and management. Ther Adv Musculoskel Dls 2009;1:107-25.
3. Ralston, S.H. Pathogenesis of Paget's disease of bone. Bone 2008;43:819-25.
4. Slrls ES, Canfleld RE. Paget's disease of bone. Trends Endocrinol Metab. 1991;6:207-12.
5. Slrls ES, Lyles KW, Singer FR, Meunler PJ. A clinical approach to diagnosis and management of Paget's disease of bone. J Bone Miner Res 2001;16:1379-87.
6. Grlz L, Caldas G, Banderia C, Assunçao V, Banderia F. Paget's disease of bone. Arq Bras Endocrinol Metab 2006;50:814-22.
7. P.D. Delmas, P.J. Meunler. The management of Paget's disease of bone. N Engl J Med 1997;336:558-66.
8. Langston AL, Ralston SH. Management of Paget's disease of bone. Rheumatology 2004;43:955-9.
9. Hamdy RC, Moore S, LeRoy J. Clinical presentation of Paget's disease of the bone in older patients. South Med J 1993;86:1097-100.
10. Bezza A. Sacro-lllac involvement in the course of Paget disease. Report of 6 cases. Pres Med 1999;28:1157-9.
11. Marcelll C. Pagetlc vertebral ankylosis and diffuse idiopathic skeletal hyperostosis. Spine 1995;20:454-9.
12. Imboden J, Hellmann DB, Stone JH. Section II rheumatoid arthritis & spondyloarthropathies. In: Current Rheumatology Diagnosis & Treatment. Vol Chapter 18: Spondyloarthropathies. 1st ed. United States of America: The McGraw-Hill Companies, Inc.; 2004.
13. Wermers RA, Tiegs RD, Atkinson EJ, Achenbach SJ. Morbidity and mortality associated with Paget's disease of bone: a population-based study. J Bone Miner Res 2008;23:819-23.
14. Hansen MF, Nelllssery MJ, Bhatla P. Common mechanisms of osteosarcoma and Paget's disease. J Bone Miner Res 1999;14:39-44.
15. PL Selby, MWJ Davie, SH Ralston, MD Stone. Guidelines on the Management of Paget's Disease of Bone. Bone 2002;3:366-73.
16. I Fogelman, D Carr. A comparison of bone scanning and radiology in the assessment of patients with symptomatic Paget's disease. Eur J Nuclear Med 1980;5:417-21.

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