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Ginseng Uygulamasının Sporcularda ve Sedanterlerde Nitrik Oksit ve Malondialdehit Üzerine Etkisi

Effect of Ginseng Supplementation on Nitric Oxide (NO) and Malondialdehyde (MDA) in Athletes and Sedentary Subjects

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Abstract (2. Language): 
It was aimed in study that effects of the application of ginseng on sedentary and plasma Nitric Oxide (NO) and Malondialdehyde (MDA) levels of the athletes who do exercise. Totally 28 volunteer reagent comprising from 14 healthy male athletes and 14 healthy male sedentary students have been used in study. Reagents have separated 4 groups equally; Group 1: Sedentary; S (n:7), Group 2: Sedentary reinforced by ginseng; GS (n:7) Group 3: Exercise; E (n:7), Group 4: exercise reinforced by ginseng; GE (n:7). 20 m shuttle run test have been done regularly to the reagents in E and GE groups along with six months 5 days in a week. It was provided for reagents who were included in GS and GE groups taking 500 mg/kg ginseng orally along with 45 days every morning at 10.00 and evenings at 19.00. Before entering exercise period and starting ginseng reinforcement, blood samples were taken from all reagents. After blood samples were taken, exercise test which was stated were applied to the E and GE groups. Just after ginseng reinforcement with 45 days and exercise period, second blood samples were taken from all groups. Plasma NO and MDA levels were determined with calorimetric method from the blood sampled taken. It was found in the study that exercise group’s plasma NO level is higher when it was compared with control group (P<0.05). As for there is not an important difference between plasma NO levels of the reagents in other groups. On the other hand, when plasma MDA levels were examined of the groups it was seen that plasma MDA level of exercise group is much more than the other three groups (P<0.05). Consequently, while from the groups that have been done exercise Group 3’s free radical and antioxidant parameter levels is different from control group in general, it makes us think not being determined any difference in same values of Group 4 applied ginseng that ginseng may be an effective material in correct changing parameter values because of exercise.
Abstract (Original Language): 
Bu araştırmada ginseng uygulamasının sedanterlerde ve egzersiz yapan sporcularda plazma Nitrik Oksit (NO) ve Malondialdehit (MDA) düzeyleri üzerine etkisi amaçlandı. Araştırmada 14 sağlıklı erkek sporcu ve 14 sağlıklı erkek sedanter öğrenci olmak üzere toplam 28 gönüllü denek olarak kullanıldı. Denekler eşit sayıda 4 gruba ayrıldı; Grup 1: Sedanter; S (n:7), Grup 2: Ginseng takviyeli sedanter; GS (n:7) Grup 3: Egzersiz; E (n:7), Grup 4: Ginseng takviyeli egzersiz; GE (n:7). E ve GE gruplarındaki deneklere 6 hafta boyunca haftada 5 gün 20 m mekik koşu testi düzenli olarak yaptırıldı. GS ve GE grubuna dahil olan deneklerin 45 gün boyunca her sabah saat 10.00’da ve akşam 19.00’da oral olarak 500 mg/kg dozunda ginseng almaları sağlandı. Bütün deneklerden egzersiz periyoduna ve ginseng takviyesine başlamadan önce kan örnekleri alındı. Kan örneklerinin alınmasından sonra E ve GE gruplarına belirtilen egzersiz testi uygulandı. 45 günlük ginseng takviyesi ve egzersiz periyodundan hemen sonra tüm gruplardan ikinci kan örnekleri alındı. Alınan kan örneklerinden plazma NO ve MDA düzeyleri kalorimetrik yöntemle belirlendi. Çalışmada kontrol grubu ile karşılaştırıldığında egzersiz grubun plazma NO düzeyinin daha yüksek olduğu bulundu (P<0.05). Diğer gruplardaki deneklerin plasma NO düzeyleri arasında ise önemli bir farklılık yoktur. Diğer yandan grupların plazma MDA düzeyleri incelendiğinde ise egzersiz grubunun plazma MDA düzeyinin diğer üç gruptan daha fazla miktarda olduğu görüldü (P<0.05). Sonuç olarak bu çalışmada egzersiz yaptırılan gruplardan Grup 3’ün serbest radikal ve antioksidan parametre düzeyleri genelde kontrol grubundan farklı iken, ginseng uygulanan Grup 4’ün aynı değerlerinde herhangi bir farklılık belirlenmemesi, egzersiz nedeniyle değişen parametre değerlerinin düzeltilmesinde ginsengin etkili bir madde olabileceğini düşündürmektedir.

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