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HIF-1: İki Ucu Keskin Bıçak

HIF-1: Two Sharp Sided Knife

Journal Name:

  • Smyrna Tıp Dergisi

Publication Year:

  • 2016

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
During hypoxic conditions, regulation of several genes by hypoxia inducible factor-1 (HIF-1) provides critical adaptations to cells in the situation. Heterodimeric transcription factor HIF-1 functions as a master regulator of oxygen homeostasis in almost all nucleated mammalian cells, regulating the expression of a myriad of genes involved in angiogenesis, iron metabolism, glucose metabolism, and cell proliferation/survival. Also HIF-1 is regulated by a variety of mechanisms including transcription, translation, post-translational modification, protein-protein interaction and degradation. This review will focus on the current knowledge of HIF-1 structure, its interacting proteins and, targeting genes as well as the concomitant functional relationships between them.
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Abstract (Original Language): 
Hipoksik koşullarda hücreler, hipoksi ile indüklenen faktör 1 (HIF-1) tarafından regüle edilen ve kritik adaptasyonları yöneten birçok gen ile var olan duruma uyum sağlar. Heterodimerik bir yapıya sahip HIF-1 nükleusa sahip memeli hücrelerinde anjiogenez, demir metabolizması, glukoz metabolizması, hücre prolifersayonu ve sağ kalımı gibi olaylarla ilişkili çok sayıdaki genin regülasyonundan sorumlu temel transkripsiyon faktörü olarak görev yapmaktadır. HIF-1 de transkripsiyon, translasyon, post-translasyonel modifikasyon, protein-protein etkileşimleri ve degredasyon gibi farklı mekanizmalar ile regüle edilmektedir. Bu derleme ile HIF-1'in yapısına, ilişkili olduğu proteinlere, hedef genlere ve aralarındaki fonksiyonel birlikteliklere değinilmek amaçlanmıştır.
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