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Mesane içine Bacillus Calmette-Guerin uygulanması sonrası gelişen reaktif artrit: Bir olgu sunumu

Bacillus Calmette-Guerin induced reactive arthritis: A case report

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Abstract (2. Language): 
Intravesical administration of Calmette-Guerin (BCG) bacillus is well known to be effective in the treatment of superficial bladder carcinoma. Arthritis and arthralgia are among the rare side effects of this treatment. Here, we present a 65-year-old male developing oligoarthritis one week after the fourth instillation of BCG. Wrist, knee and ankle joints were involved asymmetrically. He was HLA-B27 negative. He responded well to indomethacin and isoniazide treatment. After 3 months, all symptoms disappeared and laboratory results returned to normal. One year later the patient is still asymptomatic.
Abstract (Original Language): 
Bacillus Calmette-Guerin (BCG) uygulaması süperfisiyal mesane karsinomlarında kullanılan etkin bir tedavi metodudur. Bu tedavi sırasında nadiren reaktif olarak artrit ve artraljiler gelişebilmektedir. Burada, mesaneye dördüncü BCG uygulanışından bir hafta sonra oligoartrit kliniği gelişen 65 yaşındaki bir erkek hasta sunulmaktadır. El bileği, diz ve ayak bileği eklemlerinde asimetrik artrit ile başvuran hastada HLA-B27 testi negatif idi. Üç ay süreli indometazin ve izoniazid kombinasyonu tedavisi sonrası tüm semptomlar kayboldu, akut faz reaktanları normal değerlere indi. Bir yıl takibi sonrasında bile hasta eklemler açısından asemptomatik idi.
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REFERENCES

References: 

1. Jawad AS, Kahn L, Copland RF, Henderson DC, Abdul-Ahad AK. Reactive arthritis associated with Bacillus Calmette-Guerin immunotherapy for carcinoma of the bladder: a report of two cases. Br J Rheumatol 1993; 32(11): 1018-1020.
2. Lamm DL, Van Der Meijden ADPM, Morales A, et al. Incidence and complications of bacillus Calmette-Guerin intravesical therapy in superficial bladder cancer. J Urol 1992; 147:596-600.
3. Orihuela E, Herr HW, Pinsky CM, Whitmore WF Jr.
Toxicity of intravesical BCG and its management in patients with superficial bladder tumors. Cancer 1987;
60:326-333.
4. Schwartzenberg JM, Smith DD, Lindsley HB. Bacillus Calmette-Guerin associated arthropathy mimicking undifferentiated spondyloarthropathy. J Rheumatol 1999; 26(4):
933-935.
5. Mas AJ, Romera M, Valverde Garcia JM. Articular manifestations after the administration of intravesical BCG. Joint Bone Spine 2002; 69(1): 92-93.
6. Nesher G. Bacillus Calmette-Guerin induced reactive arthritis. J Rheumatol 1999; 26(7): 1638.
7. Buchs N, Chevrel G, Miossec P. Bacillus Calmette-Guerin induced aseptic arthritis: an experimental model of reactive arthritis [editorial]. J Rheumatol 1998; 25:1662-1665.
8. Southwood TR Hancock EJ, Petty RE, Malleson PN, Theisen PN. Tuberculous rheumatism (Poncet's disease) in a child. Arthritis Rheum 1988; 31:1311-1313.
9. Southwood TR, Gaston JSH. The molecular basis of Poncet's disease. Br J Rheumatol 1990; 29: 491.
10. Schaeverbeke T, Sibilia J, Mazaroff V, et al. Molecular detection of BCG DNA in synovial fluid and urine specimens in patients with arthritis after BCG therapy for blad¬der carcinoma [abstract]. Arthritis Rheum 1999; 42 Suppl:
S339.
11. Smith MD, Chandran G, Parker A, et al. Synovial membrane cytokine profiles in reactive arthritis secondary to intravesical Bacillus Calmette-Guerin therapy. J Rheumatol 1997; 24: 752-758.
12. Torisu M, Miyahara T, Shinohara N, Ohsatgo K, Sonazaki, H. A new side effect of BCG immunotherapy. BCG induced arthritis in man. Cancer Immunol Immunother
1978; 5:77-83.
13. Chevrel G, Zech C, Miossec P. Severe uveitis followed by reactive arthritis after bacillus Calmette-Guerin therapy. J Rheumatol 1999; 26(4): 1011.

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