You are here

Fibromyalji'li hastalarda serum 25-hidroksi D vitamini ve parathormon düzeyleri

Serum 25-hydroxy vitamin D and parathormon levels in patients with fibromyalgia

Journal Name:

Publication Year:

Keywords (Original Language):

Abstract (2. Language): 
Recent studies reported that low vitamin D levels are related to nonspesific musculoskeletal symptoms. The aim of this study was to investigate the vitamin D and parathormon levels in premenopousal women with fibromyalgia and to compare with control group who are similar according to age, race, skin color, climate and latitute with the study group. The study group consists of 34 premenopausal women with fibromyalgia and the control group consists of 34 healty premenopausal women. Serum parathormon levels were found significantly higher in fibromyalgia group than the control group. Despite vitamin D levels were lower in fibromyalgia group this difference was not found statistically significant. We could not explain high level of parathormon in patients with fibromyalgia, so further studies are needed to investigate the role of parathormon in fibromyalgia.
Abstract (Original Language): 
Son zamanlarda yapılan çalışmalar düşük D vitamini düzeyleri ile nonspesifik kas iskelet sistemi semptomları arasında ilişki olduğunu bildirmektedir. Bu çalışmanın amacı fibromyaljili hastalarda D vitamini ve parathormon düzeylerini araştırmak ve bu değerlerin yaş, ırk, deri rengi, iklim, enlem özellikleri açısından aynı olan kontrol grubu değerleri ile karşılaştırmaktır. Çalışmaya 34 fibromiyaljili premenopozal kadın ve 34 sağlıklı premenopozal kadın alındı. Serum parathormon düzeyleri fibromiyaljili hastalarda kontrol grubuna göre anlamlı şekilde yüksek bulundu. D vitamini düzeyleri fibromiyaljili grupta düşük bulunmakla birlikte, bu fark istatistiksel olarak anlamlı değildi. pibromiyaljili hastalarda yüksek parathormon düzeylerini izah edemiyoruz. Bu nedenle fibromiyaljide parathormonun rolünü araştıran daha ileri çalışmalara ihtiyaç vardır.
26-30

REFERENCES

References: 

1. Holick MF. Too little vitamin D in premenopausal women: why should we care?. Am J Clin Nutr 2002;76:3-4
2. Reginato AJ, Falasca GF, Pappu R, McKnight B, Agha A. Musculoskeletal manifestation ofosteomalacia: report of26 cases and literature review. Semin Artritis Rheum 1999;28:287-304
3. Chapuy MC, Preziosi P, Maamer M, Arnaud S, Galan P, Hercberg S, Meunier PJ. Prevalence ofVitamin D Insufficiency in an Adult Normal Population. Osteoporos Int 1997;7:439-43
4. Mishal AA. Effects ofdifferent dress styles on vitamin D levels in healthy young Jordanian women. Osteoporos Int2001;12:931-5
S.D.Ü. Tıp pak.
Derg
. 2006:13(2)/ 26-30
30
Yener, pibromiyaljide D vitamini ve PTH
5. Scharla SH. Prevalence of subclinical vitamin D deficiency in different European countries. Osteoporos Int 1998;8:7-12
6. Carnevale V, Modoni S, Pileri M, Di Giorgio A, Chiodini I, Minisola S, Vieth R, Scillitani A. Longitudinal evaluation ofvitamin D status in healthy subjects from southern Italy: Seasonal and gender differences. Osteoporos Int 2001;12:1026-30
7. Holick MF. Vitamin D:the underappreciated D-lightful hormone that is important for skeletal and cellular health. Curr Opin Endocrinol Diabetes 2002;9:87-98.
8. Zanello SB, Collins ED, Marinissen MJ, Norman AW, Boland RL. Vitamin D receptor expression in chicken muscle tissue and cultured myoblast. Horm Metab Res. 1997 May;29(5):231-6
9. PlotnikoffGA, Quigley JM. Prevalence ofsevere hypovitaminosis D in patients with persistent, nonspecific musculoskeletal pain. Mayo Clin Proc. 2003;78:1463-70.
10. Mascarenhas R, Mobarhan S. Hypovitaminosis D-induced Pain. Nutrition Reviews, 2004;62:354-9
11. Al-AllafAW, Mole PA, Paterson CR, Pullar T. Bone health in patients with fibromyalgia. Rheumatology 2003;42:1202-6
12. Huisman A.M, Whıte K.P, Algra A, Harth M, Vıeth R, Jacobs J.W.J, Bıjlsma, and Bell A.D. Vitamin D levels in women with systemic lupus erythematosus and fibromyalgia. J Rheumatol 2001;28:2535-9
13. Thomas MK, Demay MB Vitamin D deficiency and disorders ofvitamin D metabolism. J Endocrinol Metab Clin North Am2000;29:611-27
14. Gannage -Yared MH, Chemali R, Yaaccoub N, Halaby G Hypovitaminosis Dina sunny country: relation to lifestily and bone markers. J Bone Miner Res
2000;15:1856-62
15. Glerup H, Mikkelsen K, Poulsen L, Hass E, Overbeck S, Thomsen J, Charles P, Eriksen EF, Commonly recommended daily intake ofvitamin D is not sufficient if sunlight exposure is limited. J Intern Med
2000;247:260-8
16. Wolfe F. Smythe HA, Yunus MB, Bennett RM, Bombardier C, Goldenberg DL, et al. The American Collage ofRheumatology 1990 criteria for the classification offibromyalgia. Report ofthe Multicenter CriteriaCommittee. Arthritis Rheum. 1990;33(2):160-
72.
17. Hollick MF. Vitamin D: a millenium perspective. J Cell Biochem.2003;88:296-307.
18. Akkuş S, Tamer M.N, Yorgancigil H. A case of osteomalacia mimicking ankylosing spondylitis Rheumatol Int 2001;20:239-42
19. Akkuş S, Okudan B, Yener M, Cindaş A, Savaş S, Yıldız M. Bone mineral density and biochemical markers ofbone turnover in patients with fibromyalgia. Osteoporosis Int 2005;16:S78-9 (abstract).
20. Chou FF, Lee CH, Chen JB, Hrang SC, Lee CT. Sleep disturbances before and after parathyroidectomy for secondaryhyperparathyroidism. Surgery2005; 137(4):
426-30.
21. Korszun A. Melatonin levels in women with FMS and CFS. J Rheumatol 1999; 2 6(12): 2675-80
22. Gannage -Yared MH, Chemali R, Yaacoob N, Halaby G. Hypovitaminosis Dina sunny country: relation to lifestyle and bone markers. J Bone Miner Res 2000 Sep; 15(9): 1856-62
23. Raphael KG, Marbach JJ Comorbid fibromyalgia accounts for reduced fecundity in women with myofascial face pain. Clin J Pain 2000;16: 29-36.
24. Schoctat T, Beckmann Sociodemographic characteristics, risk factors and reproductive history in subjects with fibromyalgia-results ofapopulation-based case-control study. Z Rheumatol 2003;62: 46¬59.
25. Gür A, Cevik R, Nas K, Colpan L, Sarac S. Cortisol and hypothalamic-pituitary-gonadal axis hormones in follicular-phase women with fibromyalgia and chronic fatigue syndrome and effect ofdepressive symptoms on these hormones. Arthritis Research Therapy 2004;6:
232-8.
26. Korszun A, Young AE, Engleberg NC. Follicular phase hypothalamic-pituitary-gonadal axis function in women with fibromyalgia and chronic fatigue syndrome. J Rheumatol2000;27: 1526-30.
27. Macfarlane TV, Blinkhorn A, Worthington HV, Davies RM, Macfarlane GJ. Sex hormonal factors and chronic widespread pain: a population study among women. Rheumatology2002;41: 454-7.

Thank you for copying data from http://www.arastirmax.com