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Yenidoğan bebeklerde önemli bir hematolojik sorun: Polisitemi

An important hematologic complication in newborn infants: Polycythemia

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Abstract (2. Language): 
Neonatal polycythemia is an important hematologic problem in neonatal intensive care unit. The incidence of neonatal polycythemia is 1-5%. Some of the newborn infants have risk factors for polycythemia such as intrauterine hypoxemia, maternal diabetes, preeclampsia, chromosomal disorders, maternal smoking and inappropriate cord clemping. Several organ dysfunction may occur related to hyperviscosity in polycythemic infants. Partial exchange transfusion is the treatment regimen in neonatal polycythemia and normal saline is prefered.
Abstract (Original Language): 
Yenidoğan yoğun bakım ünitelerinde polisitemi önemli bir hematolojik sorundur, ve yenidoğanlarda %1-5 arasında görülmektedir. Bazı yenidoğan bebeklerde intrauterin hipoksi, annede diyabet, preeklampsi, kromozomal hastalıklar, annenin gebelikte sigara içmesi ve doğum sonrası göbek kordonunun klemplenmesinde sorunlar gibi polisitemi için risk oluşturan durumlar söz konusudur. Polisitemi olan bebeklerde hiperviskozite nedeniyle çoğu organ ve sistemlerde fonksiyon kaybı olabilir. Polisitemi tedavisinde serum fizyolojik kullanılarak parsiyel kan değişimi uygulanmaktadır.
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REFERENCES

References: 

1. Werner EJ. Neonatal polycythemia and hyperviscosity. ClinPerinatol 1995; 22: 693-710.
2. Peevy KJ. Polycythemia and hyperviscosity. In: Gomella TL, Cunningham MD, Eyal FG, Zenk KE eds. Neonatology. Appleton Lange. Stamford, 1999:
322-25.
3. FanaroffAA, Maisels MJ, Stevenson DK. The Year Book ofNeonatal and Perinatal Medicine. Mosby, St. Louis, 1998: 297-99.
4. Mentzer WC, Glader BE. Polycthemia. In: Taeusch HW, Ballard RA, eds. Avery's Diseases ofthe Newborn. W.B. SaundersCompany, Philadelphia, 1998: 1104¬06.
5. Drew JH, Guaran RL, Cichello M, Hobbs JB.Neonatal whole blood hyperviscosity: the important factor influencing later neurologic function is the viscosityandnotthepolycythemia. 1997; 17: 67-72.
6. Sugama S, Kusano K. Monozygous twin with polymicrogyria and normal co-twin. Pediatr Neurol 1994; 11: 62-3.
7. Arendar G, Samara E, Palmas C. Neonatal acquired paraplegia: retrospective review of30 patients. J Pediatr OrthopB 1999; 8: 80-3.
8. Johnson MM, Rodden DJ, Collins S. Newborn hematology. In: Merenstein GB, Gardner SL.,eds. Handbook ofNeonatal Intensive Care. Mosby, St. Louis, 1998: 379-81.
9. Rosenkrantz TS. Polycythemia and hyperviscosity in the newborn. 2003; 29: 515-27.
S.D.Ü. Tıp pak.
Derg
. 2006:13(3)/ 36-42
Çetin, Yenidoğanlarda polisitemi
41
10. Zenk KE. Polycythemia. In: GomellaTL, Cunningham MD, Eyal FG, Zenk KE eds. Neonatology. Appleton Lange. Stamford, 1999: 277-79.
11. Pappas A, Delaney-Black V. Differential diagnosis and managementofpolycythemia. 2004;51: 1063-86.
12. Carmi D, Wolach B, Dolfin T, Merlob P. Polycythemia ofthe preterm and full-term infant: relationship between hematocrit and gestational age, total blood solutes, reticulocyte count, andbloodpH. BiolNeonate 1992; 61: 173-8.
13. Drew JH, Guaran RL, Grauer S, Hobbs JB. Cord whole blood hyperviscosity: measurement, definition, incidence and clinical features. J Peadiatr Child Health 1991; 27: 363-5.
14. Rosenkrantz TS, Philipps AF, Skrzypczak PE, Raye JR. Cerebral metabolism in the newborn lamb with polycythemia. Pediatr Res 1988; 23: 329-33.
15. Rosenkrantz TS, Philipps AF, Knox I, Zalneraitis EL, Porte PJ, Skrzypczak PE et al. Regulation ofcerebral glucose metabolism in normal and polycythemic newborn lambs. J Cereb Blood Flow Metab 1992; 12:
856-65.
16. Norman M, Fagrell B, Herin P. Effects ofneonatal polycythemia and hemodilution on capillary perfusion. JPediatr 1992; 121: 103-8.
17. Cordero L, Treuer SH, Landon MB, Gabbe SG. Management ofinfants ofdiabetic mothers. Arch Pediatr Adolesc Med 1998; 152: 249-54.
18. Green DW, Khoury J, Mimouni F. Neonatal hematocrit and maternal glycemic control in insulin-dependent diabetes.JPediatr 1992; 120: 302-5.
19. Kurlat I, Sola A. Neonatal polycythemia in appropriately grown infants ofhypertensive mothers. Acta Paediatr 1992;81:662-4.
20. Narang A, Chaudhuri MK, Kumar P. Small for gestational age babies: Indian scene. Indian J Pediatr 1997; 64: 221-4.
21. Merchant RH, Phadke SD, Sakhalkar VS, Agashe VS, Puniyani RR. Hematocrit and whole blood viscosity in newborns: analysis of 100 cases. Indian Pediatr 1992;29: 555-61.
22. Widness JA, Pueschel SM, Pezzullo JC, Clemons GK. Elevated erythropoietin levels in cord blood ofnewborns with Down's syndrome. Biol Neonate 1994; 66: 50¬5.
23. Kivivuori SM, Rajantie J, Siimes MA. Peripheral blood cell counts in infants with Down's syndrome. Clin Genet 1996; 49: 15-9.
24. Honma Y, Minakami H, Eguchi Y, Uchida A, Izumi A, Sato I. Relation between hemoglobin discordance and adverse outcome in monochorionic twins. Acta Obstet Gynecol Scand 1999; 78:207-11.
25. Awonusonu FO, Pauly TH, Hutchison AA. Maternal smoking and partial exchange transfusion for neonatal polycythemia. 2002;19:349-54.
26. Murphy DJ Jr, Reller MD, Meyer RA, Kaplan S. Effects of neonatal polycythemia and partial exchange transfusion on cardiac function. Pediatrics 1985; 76:
909-13.
27. Black VD, Rumack CM, Lubchenco LO, Koops BL. Gastrointestinal injury in polycythemic term infants. Pediatrics 1985; 76: 225-31.
28. Wilson R, del Portillo M, Schmidt E, Feldman RA, Kanto WP Jr. Risk factors for necrotizing enterocolitis in infants weighing more than 2000 grams at birth. Pediatrics 1983; 71: 19-22.
29. Wiswell TE, Cornish JD. Fresh frozen plasma partial exchange transfusion and necrotizing enterocolitis. Pediatrics 1986; 77: 786-7.
30. Hein HA, Lathrop SS. Partial exchange transfusion in term, polycythemic neonates: absence ofassociation with severe gastrointestinal injury. Pediatrics 1987; 80: 75-8.
31. Boehm G, Delitzsch AK, Senger H, DelSanto A, Moro G, Minoli I. Postnatal development ofliver and exocrine pancreas in polycythemic newborn infants. J Pediatr GastroenterolNutr 1992; 15: 310-4.
32. Walker JR, Casale AJ. Prolonged penile erection in the newborn. Urology 1997; 50: 796-9.
33. Saggese G, Bertelloni S, Baroncelli GI, Cipolloni C. Elevated calcitonin-gene related peptide in polcythemic newborn infants. Acta Paediatr 1992; 81: 966-8.
34. LeBlanc MH, Edwards JD. Acute polycythemia increases the disappearance rate ofclottable fibrinogen in the newborn dog. Pediatr Res 1986; 20: 151-54.
35. Katz J, Rodriguez E, Mandani G, Branson HE. Normal coagulation findings, trombocytopenia, and peripheral hemoconcentration in neonatal polycythemia. J Pediatr 1982; 101: 99-102.
36. Peters M, ten-Cate JW, Koo LH, Breederveld C. Persistent antithrombin III deficiency: risk factor for thromboembolic complications in neonates small for gestational age. J Pediatr 1984; 105: 310-14.
37. Rivers RP. Coagulation changes associated with high hematocrit in the newborn infant. Acta Paediatr Scand 1975; 64: 449-56.
38. Acunas B, Celtik C, Vatansever U, Karasalihoglu S. Trombocythopenia: an important indicator for the application ofpartial exchange transfusion in polycythemic newborn infants? Pediatr Int 2000;42:
343-7.
39. Stuart MJ, Sunderji SG, Allen JB. Decreased prostacyclin production in the infant ofthe diabetic mother. J Lab Clin Med 1981; 98: 412-16.
40. Scott F, Evans N. Distal gangrene in a polycythemic recipient fetus in twin-twin transfusion. Obstet Gynecol 1995; 86: 677-9.
41. Letts M, Blastorah B, al-Azzam S. Neonatal gangrene ofthe extremities.JPediatrOrthop 1997; 17: 397-401.
42. Villalta IA, Pramanik AK, Diaz-Blanco J, Herbst JJ.
S.D.Ü. Tıp pak.
Derg
. 2006:13(3)/ 36-42
42
Çetin, Yenidoğanlarda polisitemi
Diagnostic errors in neonatal polycythemia based on method ofhematocrit determination. J Pediatr 1989; 115: 460-2.
43. Herzog B, Felton B. Hemoglobin screening for normal newborns. J Perinatol 1994; 14: 285-9.
44. Bada HS, Korones SB, Pourcyrous M, Wong SP, Wilson WM, Kolni HW, et al. Asymptomatic syndrome of polycythemic hyperviscosity: effect ofpartial plasma exchange transfusion. J Pediatr 1992; 120: 579-85.
45. Delaney-BlackV, Camp BW, Lubchenco LO, Swanson C, Roberts L, Gaherty P, et al. Neonatal hyperviscosity association with lower achievement and IQ scores at school age. Pediatrics 1989; 83: 662-7.
46. Roithmaier A, Arlettaz R, Bauer K, Bucher HU, Krieger M, Duc G, et al. Randomized controlled trial ofRinger solution versus serum for partial exchange transfusion in neonatal polycythemia. Eur J Pediatr 1995; 154: 53¬6.
47.de Waal KA, Baerts W, Offringa M. Systematic review ofthe optimal fluid for dilutional exchange transfusion in neonatal polycythaemia. 2006; 91: F7-10.
48. Dempsey EM, Barrington K. Crystalloid or colloid for partial exchange transfusion in neonatal polycythemia: a systematic review and meta-analysis. 2005; 94: 1650-5.
49. Liem KD, Hopman JC, Oeseburg B, de Haan AF, Kollee LA. The effect ofblood transfusion and haemodilution on cerebral oxygenation and haemodynamics in newborn infants investigated by near infrared spectrophotometry. Eur J Pediatr 1997; 156: 305-10.
50. Black VD, Lubchenco LO, Luckey DW, Koops BL, McGuinness GA, Powell DP et al. Developmental and neurologic sequelae ofneonatal hyperviscosity syndrome. 1982;69:426-31.
51. Dempsey EM, Barrington K. Short and long term outcomes following partial exchange transfusion in the polycythaemic newborn: a systematic review. 2006; 91:F2-6.
52. Capasso L, Raimondi F, Capasso A, Crivaro V, Capasso R, Paludetto R. Early cord clamping protects at-risk neonates from polycythemia. 2003;83:197-200.

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