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Antenatal kortikosteroit uygulamalarındaki güncel gelişmeler

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Abstract (2. Language): 
General measures and tocolytic treatments are usually unsuccessful for preventing preterm births. Dexamethasone or betamethasone, when administered maternally prior to delivery, accelerate fetal lung maturation and decrease the incidence of respiratory distress syndrome. In the present review, latest developments on antenatal corticosteroid therapy have been discussed. Recent data indicate that antenatal corticosteroid treatment would be completed as a single or rescue course at least 14 days apart between 26 to 36 weeks' gestation and by using betamethasone, but not dexamethasone.
Abstract (Original Language): 
Preterm doğumları engellemede genel önlemler ve tokolitik tedaviler çoğunlukla başarısız olmaktadır. Doğum öncesi anneye verilen deksametazon ve betametazon, fetal akciğer gelişimini hızlandırarak erken doğan bebeklerde respiratuvar distres sendromu sıklığını azaltmaktadır. Mevcut derlemede, antenatal kortikosteroit tedavisine dair en son gelişmeler tartışılmıştır. Yeni bulgular, antenatal kortikosteroit tedavisinin deksametazon yerine betametazon kullanılarak 26-36. gebelik haftaları arasında, tek veya en az 14 gün aralık ile iki kür uygulama şeklinde yapılmasına işaret etmektedir.
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REFERENCES

References: 

1.
Derben
t A, Turhan A, Öztürk N. Erken doğum riski ve
tahmini. Yeni Tıp Dergisi 2009; 26: 139-144
2.
Bülbü
l A, Okan F, Şahin S, Nuhoğlu A. Düşük doğum
ağırlıklı erken doğmuş bebeklerde erken dönem hastalık ve ölüm oranı sonuçları. Türk Pediatri Arşivi 2008; 43: 94-98
3.
Şahi
n NH, Oskay Ü. Prematüre bebekleri yenidoğan
yoğun bakım ünitesinde yatan ebeveynlerde ortaya çıkan stresörler. Çocuk Dergisi 2008; 8: 108-113
4. Kream J, Mulay S, Fukushima DK, Solomon S. Determination ofplasma dexamethasone in the mother and the newborn after administration ofthe hormone in a clinical trial. J Clin Endocrinol Metab. 1983; 56: 127-33
5. Crowley P. Prophylactic corticosteroids for preterm birth. Cochrane Database Syst Rev 2000; 2: CD000065
6. Mulder EJ, Derks JB, Visser GH. Antenatal corticosteroid
therapy and fetal behavior: a randomised study ofthe effects of betamethasone and dexamethasone. Br J ObstetGynaecol. 1997; 104: 1239-47
7. Ballard PL, Granberg P, Ballard RA. Glucocorticoid
levels in maternal and cord serum after prenatal betamethasone therapy to prevent respiratory distress syndrome. J Clin. Invest 1975; 56: 1548-54
8. Anceschi MM, Palmerini CA, Codini M, Luzi P, Cosmi
EV. Collagen and elastin in rabbit fetal lung: Ontogeny and effects ofsteroids. J Dev Physiol 1992; 18: 233¬6
9. Rayburn WF, Christensen HD, Gonzalez CL. A placebo-
controlled comparison between betamethasone and dexamethasone for fetal maturation: differences in neurobehavioral development ofmice offspring. Am J ObstetGynecol 1997; 176: 842-50
S.D.Ü. Tıp pak.
Derg
. 2011:18(4)/144-149
Antalyalı, antenatal steroitler
148
10. Rayburn WF, Christensen HD, Gonzalez CL. A placebo-controlled comparison between betamethasone and dexamethasone for fetal maturation: differences in neurobehavioral development ofmice offspring. Am J ObstetGynecol 1997; 176: 842-51
11. Brownfoot FC, Crowther CA, Middleton P. Different corticosteroids and regimens for accelerating fetal lung maturation for women at risk ofpreterm birth. Cochrane Database Syst Rev. 2008; 4: CD006764
12. National Institutes ofHealth Consensus Development Conference Statement. Effect of corticosteroids for fetal maturation on perinatal outcomes. JAMA 1995; 273: 413-8
13. Roberts D, Dalziel S. Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database of Systematic Reviews. 2006, Issue 3. Art. No: CD004454. DOI: 10.1002/14651858
14. Elimian A, Verma U, Beneck D, Cipriano R, Visintainer P, Tejani N. Histologic chorioamnionitis, antenatal steroids, and perinatal outcomes. Obstet Gynecol. 2000; 96: 333-6
15. Murphy K, Aghajafari F. Single versus repetitive courses ofcorticosteroids: what do we know? Clin Obstet Gynecol 2003; 46:161-73
16. D'Amore A, Ahluwalia J, Cheema I, Prentice A, Kaptoge S, Kelsall W. The effect of antenatal corticosteroids on fetal growth, survival, and neurodevelopmental outcome in triplet pregnancies. Am J Perinatol. 2004; 21:1-8
17. Jobe AH, WadaN, Berry LM, Ikegami M, Ervin MG. Single and repetitive glucocorticoid exposures reduce fetal growth in sheep. Am J Obstet Gynecol. 1998; 178: 880-5
18. Huang WL, Harper CG, Evans SF, Newnham JP, Dunlop SA. Repeated prenatal corticosteroid administration delays myelination of the corpus callosum in fetal sheep. Int J Dev Neurosci. 2001; 19:
415-25
19. National Institutes ofHealth Consensus Development Panel: Antenatal corticosteroids revisited: repeat courses-National Institutes of Health Consensus Development Conference Statement, August 17-18, 2000. Obstet Gynecol. 2001; 98: 144-50
20. Guinn DA, Atkinson MW, Sullivan L, et al. Single vs weekly courses ofantenatal corticosteroids for women at risk of preterm delivery: a randomized controlled trial. JAMA. 2001; 286: 1581-7
21. Garite TJ, Kurtzman J, Maurel K, Clark R; Obstetrix Collaborative Research Network. Impact ofa 'rescue course' ofantenatal corticosteroids: a multicenter randomized placebo-controlled trial. Am J Obstet Gynecol. 2009; 200: 248.e1-9
22. McEvoy C, Schilling D, Peters D, Tillotson C, Spitale P, Wallen L, Segel S,et al. Respiratory compliance in
preterm infants after a single rescue course of antenatal steroids: a randomized controlled trial. Am J Obstet Gynecol. 2010; 202 :544.e1-9.
23. Ballard PL, Ballard RA. Scientific basis and therapeutic regimens for use of antenatal glucocorticoids. Int J Gynaecol Obstet.1996; 52: 326
24. Stutchfield P, Whitaker R, Russell I; Antenatal Steroids for Term Elective Caesarean Section (ASTECS) Research Team. Antenatal betamethasone and incidence ofneonatal respiratory distress after elective caesarean section: pragmatic randomisedtrial. BMJ 2005; 331:
662-7
25. Dimitriou G, Fouzas S, Georgakis V, Vervenioti A, Papadopoulos VG, Decavalas
G, et al. Determinants ofmorbidity in late preterm infants. Early Hum Dev. 2010; 86: 587-91
26. Mulder EJ, Derks JB, Visser GH. Antenatal corticosteroid therapy and fetal behavior: a randomised study of the effects of betamethasone and dexamethasone. BJOG. 1997; 104: 1239-47
27. Kelly MK, Schneider EP, Petrikovsky BM, Lesser ML. Effect ofantenatal steroid administration on the fetal biophysical profile. J Clin Ultrasound. 2000; 28: 224¬6
28.O'Shea TM, Doyle LW. Perinatal glucocorticoid therapy and neurodevelopmental outcome: an epidemiologic perspective. Semin Neonatol. 2001; 6: 293-307
29. Dessens AB, Haas HS, Koppe JG. Twenty-year follow-up of antenatal corticosteroid treatment. Pediatrics. 2000; 105: E77
30. VidaeffAC, Mastrobattista JM. Controversies in the use of antenatal steroids for fetal maturation. Semin Perinatol. 2001; 25: 385-96
31. Elliman D, Browning MCK, Forsyth CC. Adrenal axis supression due to maternal corticosteroid theraphy. PediatrRes. 1981; 15: 1187
32. McKenna DS, Wittber GM, Nagaraja HN, Samuels P. The effects ofrepeat doses ofantenatal corticosteroids on maternal adrenal function. Am J Obstet Gynecol. 2000; 183: 669-73
33. Bradley BS, Kumar SP, Mehta PN, Ezhuthachan SG. Neonatal cushingoid syndrome resulting from serial courses ofantenatal betamethasone. Obstet Gynecol. 1994; 83: 869-72.
34. Terrone DA, Smith LG Jr, WolfEJ, Uzbay LA, Sun S, Miller RC. Neonatal effects and serum cortisol levels after multiple courses of maternal corticosteroids. ObstetGynecol. 1997; 90: 819-23
35. Terrone DA, Rinehart BK, Rhodes PG, Roberts WE, Miller RC, Martin JN Jr. Multiple courses of betamethasone to enhance fetal lung maturation do not suppress neonatal adrenal response. Am J Obstet Gynecol. 1999; 180: 1349-53
36. Ogueh O, Khastgir G, Studd JW, Jones J, Alaghband-Zadeh J, Johnson MR. Antenatal corticosteroid therapy
S.D.Ü. Tıp pak.
Derg
. 2011:18(4)/144-149
149
Antalyalı, antenatal steroitler
and risk of osteoporosis. BJOG. 1998; 105: 551-5
37. Rotmensch S, Vishne TH, Celentano C, Dan M, Ben-Rafael Z. Maternal infectious morbidity following multiple courses ofbetamethasone. J Infect. 1999; 39:
49-54
38. Yunis KA, Bitar FF, Hayek P, Mroueh SM, Mikati M. Transient hypertrophic cardiomyopathy in the newborn following multiple doses ofantenatal corticosteroids. AmJPerinatol. 1999; 16: 17-21
39. Wood CE, Cheung CY, Brace RA. Fetal heart rate, arterial pressure, and blood volume responses to cortisol infusion. Am J Physiol. 1987; 253: R904-9
40. Azancot-Benisty A, Benifla JL, Matias A, De Crepy A, Madelenat P. Constriction of the fetal ductus arteriosus during prenatal betamethasone therapy. Obstet Gynecol. 1995; 85: 874-6.

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