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Helicobacter Pylori Eradikasyonunda Kıs a Süreli Uygulanan Dörtlü Tedavinin Etkinliği

Efficacy Of A Two Day Quadruple Therapy For Eradication Of Helicobacter Pylori

Journal Name:

  • Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 2000

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
AIM: To find on effective short therapy regimen for eradication of Helicobacter pylori. MATERIALS AND METHODS: Patients who had upper gastrointestinal system complaints were evaluated by physical examination, laboratory, endoscopy and histopathological findings before and I month after treatment. Patients were given lansoprazole for 5 days and then tribismuthsubcitrate, ornida-z.ole and amoxicillin were added for two days. RESULTS: We obtained the eradication rate as 86.3 % in all patients. Eradication rates were determined as 100 % in patients with ulcer and 80 % in non-ulcer patients. Side effects were seen in only 3 patients (7.1 %). DISCUSSION: Many studies were he Id for eradication of Helicobacter pylori. Nowadays, short therapy regimens are preferable because of lesser side effects. If eradication rate is the same with the long term therapy, why do patients get drags for a long time? We found our eradication rate was similar so many of the studies. So, this therapy regimen can be used as it was an effective treatment.
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Abstract (Original Language): 
AMAÇ: İki günlük dörtlü tedavinin Helicobacter pylori eradikasyonandaki etkinliğinin araştırılması. MATERYAL VE METOD: Aralık 1998-Temmuz 1999 tarihleri arasında Ankara Numune Hastanesi Gastroenteroloji Polikliniği'ne başvurup endoskopi endikasyonu konan hastalar, anamnez, fizik muayene, laboratuar bulguları, endoskopi ve lüstopatoloji sonuçları tedavi öncesi ve tedavi sonrası I. ayda değerlendirildi. Her hastaya beş gün 2*30mg/gün lansoprazol (Lansor, Sanovel) tedavisinden sonra, iki gün lansoprazolle birlikte tribizmutsubsitrat (De-Nol, Eczacibaşi) 4*300mg/gün, amoksisilin (Largopen, Bilim) 2*J000mg/gün ve ornidazol (Biteral, Roche) 2*500mg/gün uygulandı. SONUÇLAR: 36 hastanın 31 'inde (% 86.1) eradikasyon sağlandı. Eradikasyon oranı, tedavi öncesi endoskopik tanısı ülser olan II hastada % 100, gastrit olan 24 hastada % 83.3 olarak saptandı. Yan etki nedeniyle sadece 3 hastada (% 7.1) tedavi devam ettirilemedi. TARTIŞMA: Bu çalışmada saptanan eradikasyon oranları, diğer uzun ve kısa süreli tedavi yöntemlerine benzerlik göstermektedir. Bu nedenle, peptik ülser tedavisi ve Helicobacter pylori eradikasyonunda kolay uygulanabilen ve tedavi başarısı yüksek bir yöntem olarak kabul edilebilir.
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  • 4
14-18
  • Turkish

REFERENCES

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