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Preterm Eylemin Erken Tanısında Serviginal Prolaktin Değeri

Journal Name:

  • Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 2000

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Abstract (2. Language): 
We aim to investigate the relationship between prolactin in servicovaginal washings and preterm birtliwitli a prospective randomized study of pregnant women at 26-36 weeks gestation in Ankara State Hospital, Ministry of Health Department of Obstetric and Gynecology. We compared prolacting in cervicovaginal washings of 30 patients in premature labor and 30 asemp-tomatic patients. A prolactin concentration greater than 2 ng/ml was considered a positive test result. The variables were birth weight, gestational age in labor, periods between test and labor (latent period).Prolactin was found to be significantly higher in symptomatic patient than asymptomatic control group. ( 70 % vs 13 %, p<0.00l). In symptomatic patients, cervicovaginal prolactin had a 86% positive predictive value and a 67% negative predictive value for delivery at < 37 weeks gestation. Patients testing positive for prolactin had significantly shorter latency from testing to delivery (13.66± 17 vs 32.11± 26 days, p<0.05) compared with patients testing negative. Patients testing positive for prolactin had significantly lower birth weights compared with patients testing negative (2200±568.11 vs 2794.44 ± 628.21 gr, p<0.05) Prolactin was also identified in four asymptomatic patients, 3 of them were delivered before term.Cervicovaginal prolactin is a biohemical marker for preterm delivery, a shorter latency period to delivery, and lower birth weight in symptomatic patients. This test may also prove to be a valuable marker for preterm birth in asymptomatic women.
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Abstract (Original Language): 
Servikovaginal sıvıda prolaktin varlığının preterm doğumla ilişkisinin araştırılmasıamacı ile 26-35. haftalardaki gebelerde SB Ankara Hastanesi Kadın Hastalıkları ve Doğum Kliniği.prospektif randomize bir çalışma planlandı.Preterm kontraksiyonları olan 30 hasta ve asemptomatik 30 gebede servikovaginal sıvıda prolaktin ölçüldü. 2 nglmVnin üzerindeki prolaktin değeri pozitif kabul edildi. Sonuç değişkenleri doğum ağırlığı, doğumdaki gestasyonel yaş, test ile doğum arasında geçen süreden (latent periyod) oluşmaktaydı. Prolaktin semptomatik hastalarda, asemptomatik kontrol grubuna oranla önemli ölçüde fazla miktarda pozitif bulundu. ( % 70'e %13, p<0.001).Semptomatik hastalarda servikovaginal prolaktinin < 37 hafta doğum için pozitif predik-t if değeri % 86, negatif prediktif değeri % 67 bulundu. Prolaktin pozitif bulunan hastaların latent periyodları negatif olanlara göre önemli ölçüde kısaydı. (I3.66± 17'ye 32.11±26 gün p<0.05) . Prolaktin pozitif grupta doğum ağırlıkları negatif olan grupla karşılaştırıldığında önemli ölçüde düşük bulundu. (2200 ±568.11 'e 2794.44± 628.21 gr.p<0.05) .Prolaktin pozitif olan asemptomatik 4 hastanın 3 tanesi preterm doğurdu. Servikovaginal prolaktin, semptomatik hastalarda preterm doğum, kısa latent periyod ve düşük doğum ağırlığı için uygun bir biyokimyasal belirteçtir. Bu test aynı zamanda asemptomatik gebelerde preterm doğumu saptamada da yararlı olabilir.
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  • 4
10-13
  • Turkish

REFERENCES

References: 

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