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HEMODİYALİZİN PROTEİN KARBONİL İÇERİĞİ VE SÜLFİDRİL GRUBLARI DÜZEYİ ÜZERİNE ETKİSİ

EFFECTS OF HEMODIALYSIS ON PROTEIN CARBONYL CONTENT AND SULPHYDRYL GROUP LEVELS

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 2001

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
We have assessed the effect of a single episode of hemodialysis on protein carbonyl content and protein sulfydryl (SH) groups in 28 patients and 14 control subjects. In chronic renal failure (CRF) patients the carbonyl content increased when compaired to the controls (p<0.001). But there were no statistically significant changes found between pre-hemodialysis and post-hemodialysis. The protein SH groups decreased significantly in CRF patients (p<0.001). After hemodialysis the protein SH groups increased significantly (p<0.001). Base on these findings, it can be concluded that hemodialysis does not lead to any loss in protein carbonyl content but increases the protein SH groups.
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Abstract (Original Language): 
Bir hemodiyaliz, seansının protein karbonil içeriği ve protein sülfıdril (SH) grupları üzerine etkisini 28 hasta grubu, 14 kontrol grubu kullanarak araştırdık. Karbonil içeriği kronik böbrek yetmezliği (KBY) olan hastalarda kontrol grubuna göre artmış bulundu (p<0.001). Fakat hemodiyaliz, öncesi ile hemodiyaliz, sonrası arasında istatistiksel olarak anlamlı bir fark görülmedi. Protein SH grupları KBYde belirgin olarak azalmış bulundu (p<0.001). Hemodiyaliz sonrasında ise öncesi ile kıyaslandığında anlamlı olarak yükseldiği görüldü (p<0.001). Bu bulgulara dayanarak hemodiyalizin protein karbonil içeriklerini uzaklıştıramadığı fakat protein SH gruplarının artışına yol açtığı sonucuna varabiliriz.
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  • 2
83-85
  • Turkish

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