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PERİTON DİALİZ HASTALARINDA LEPTİN VE BESLENME PARAMETRELERİ ARASINDAKİ İLİŞKİ

THE ASSOCIATION BETWEEN LEPTIN AND NUTRITIONAL PARAMETERS IN PERITONEAL DIALYSIS PATIENTS

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 2003

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Protein-calorie malnutrition is an important determinant of morbidity and mortality in dialysis patients. Our objectives were to evaluate nutritional parameters including leptin levels and Kt/V in peritoneal dialysis (PD) patients. Twenty-eight PD patients (13F, 15M) were included in the study. Serum leptin, albumin, prealbumin, transferrin, insulin like growth factor-1 {IGF-I), growth hormone (GH), cholesterol, triglyceride, IgG, IgA, IgM, C3 and C4 levels along with body mass index (BMI) and body fat content (BFC) were determined. The mean leptin level was 26.2 ng/ml. The patients' BMI was 24.4 kg/m2 and BFC was 27.1%. The serum values were as follows: albumin: 35g/L, prealbumin: 40.6 mg/dl, transferrin: 2.5g/L, IGF-]: 169.3 mg/L, GH: 7.9 mg/L, cholesterol: 5.4 mmol/L, triglyceride: 2.4 mmol/L, IgG: 12.9 g/L, IgA: 1.8g/L, IgM: 1.1 g/L, C3:1.5g/L and C4: 0.3 g/L. The Kt/V was measured in 20 of the patients and its mean value was 2.1. No significant correlation was established between leptin levels and Kt/V nor any other parameters other than BMI, albumin, C3 and C4. Our results demonstrated that serum leptin level is elevated and it could only partially serve as a biochemical marker for nutritional status in PD patients.
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Abstract (Original Language): 
Diyaliz hastalarındaprotein-kalori malnütrisyonu morbidite ve mortalitenin önemli bir belirleyicisidir. Çalışmamızda periton diyalizi (PD) hastalarında leptin ile birlikte diğer nütrisyonelparametreler ve Kt/ Voranları incelenmiştir. Yirmi sekiz PD (13K, 15E) hastası çalışmaya alınmıştır. Serum leptin, albümin, prealbumin, transferrin, insulin benzeri büyüme faktörü-1 (IGF-]), büyüme hormonu (GH), kolesterol, trigliserid, IgG, IgA, IgM, C3 ve C4 düzeyleri ile birlikte vücut kitle indeksi (BMI) ve vücut yağ oranı (BFC) belirlenmiştir. Ortalama leptin düzeyi, 26.2 ng/ ml; BMI, 24.4 kg/m2 ve BFC, %o27.1 olarak bulunmuştur. Diğer sonuçlar ise şu şekildedir: albümin, 35 g/L; prealbumin, 40.6 mg/dl; transferrin, 2.5g/L; IGF-1, 169.3mg/L; GH, 7.9mg/L; kolesterol, 5.4 mmol/L; trigliserid, 2.4 mmol/L; IgG, 12.9 g/L; IgA, 1.8g/L; IgM, 1.1 g/L; C3, 1.5g/L ve C4, 0.3g/L. Yirmi hastada hesaplanabilen Kt/Vnin ortalama değeri 2.1 'dir. Leptin düzeyleri ile BMI, albumin, C3 ve C4 değerleri dışında hiç bir parameter ile anlamlı bir korelasyon saptanmamıştır. Sonuç olarak periton diyalizi hastalarında serum leptin düzeyleri yüksek olup; nütrisyonel durum hakkında ancak kismi bir parameter olarak Kabul edilebilir
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  • 1
24-28
  • Turkish

REFERENCES

References: 

1. ikizler TA. Biochemical markers: clinical aspects. J Ren Nutr 1997;7:61-64.
2. Stenvinkel P. Leptin-a new hormone of definite interest for nephrologist. Nephrol Dial Transplant 1998;13: 1099-1101.
3. Young GA, Woodrow G, Kendall S, et al. Increased plasma leptin/fat ratio in patients with chronic renal failure: a cause of malnutrition? Nephrol Dial
Transplant 1997; 12:2318-2323.
4. Widjaja A, Kielstein JT, Horn R, et al, G. Free serum leptin but not bound leptin concentrations are elevated in patients with end-stage renal disease. Nephrol Dial
Transplant 2000;15:846-850.
5. Johansen KL, Mulligan K, Tai V, Schambelan M. Leptin, body composition and indices of malnutrition in
patients on dialysis. J Am Soc Nephrol 1998;9:1080-1084.
6. Tsujimoto Y, Shoji T, Tabata T, et al. Leptin in peritoneal dialysate from continuous ambulatory peritoneal dialysis patients. Am J Kidney Dis 1999;34: 832-838.
7. Zhang Y, Proenca R, Mallei M, Barone M, Lori L,
Friedman JM. Positional cloning of the mouse ob gene and its human homologue. Nature 1994;372:425-432.
8. Considine RV. Weight regulation, leptin and growth hormone. Horm Res 1997;48:116-121.
9. Landt M, Parvin CA, Dagogo-Jack S, Bryant B, Coyne DW. Leptin elimination in hyperleptinaemic peritoneal dialysis patients. Nephrol Dial Transplant 1999; 14:
732-737.
10. Arkouche W, Juillard L, Delawari E et al. Peritoneal clearence of leptin in continuous ambulatory peritoneal
dialysis. Am J Kidney Dis 1999;34:839-844.
11. Ahima RS, Flier JS. Leptin. Annu Rev Physiol 2000;
62:413-437.
12. Esler M, Vaz M. Collier G, et al. Leptin in human plasma is derived in part from the brain and cleared by
the kidneys. Lancet 1998;351:879-880.
13. Cumin F, Baum HP, Levens N. Leptin is cleared from the circulation primarily by the kidney. Int J Obes 1996;20:1120-1126.
14. ikizler TA, Wingard RL, Harvell J, Shyr Y, Hakim RM. Association of morbidity with markers of nutrition and inflammation in chronic hemodialysis patients: a prospective study. Kidney Int 1999;55:1945-1951.
15. Lowrie EG. Acute-phase inflammatory process contributes to malnutrition, anemia, and possibly other abnormalities in dialysis patients. Am J Kidney Dis 1998;6:S105-112.
16. Durnin JV, Womersley J. Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72. Br J Nutr 1974;32:77-97.
27
17. Nordfors L, Lonnqvist F, Heimbiirger O, Danielson A, Schalling M, Stenvinkel P. Low leptin gene expression and hyperleptinemia in chronic renal failure. Kidney Int 1998;54:1267-1275.
18. Fouque D. Insulin-like growth factor I resistance in chronic renal failure. Miner Electrolyte Metab 1996; 22:133-137.
19. Fouque D, Juillard L, Lasne Y, et al. Acute leptin regulation in end stage renal failure: the role of growth
hormone and IGF-1. Kidney Int 1998;54:932-937.
20. Dagogo-Jack S. Uremic hyperleptinemia: adaptive or
maladaptive. Kidney Int 1998;54:997-998.
21. Merabet E, Dagogo-Jack S, Coyne DW, et al. Increased plasma leptin concentration in end stage renal disease. J
Clin Endocrinol Metab 1997;82:847-850.
22. Heimbürger O, Lonnqvist F, Danielsson A, Nordenstörm J, Stenvinkel P. Serum immunoreactive leptin concentration and its relation to body fat content in chronic renal failure. J Am Soc Nephrol 1997;8: 1423-1430.
23. Fontan MP, Rodriguez-Carmona A, Cordido F, Garcia-Buela J. Hyperleptinemia in uremic patients undergoing conservative management, peritoneal dialysis and hemodialysis: a comparative analysis. Am J Kidney Dis 1999;34:824-831.
24. Considine RV, Caro JF. Leptin and the regulation of
body weight. Int J Biochem Cell Biol 1997;29:1255-
1272.
25. Dagogo-Jack S, Ovalle F, Landt M, Gearing B, Coyne DW. Hyperleptinemia in patients with end stage renal disease undergoing continuous ambulatory peritoneal
dialysis. Perit Dial Int 1998;18:34-40.
26. Pereira BJ, Poutsiaka DD, King AJ, et al. In vitro production of interleukin-1 receptor antagonist in chronic renal failure, CAPD and HD. Kidney Int 1992; 42:1419-1424.
27. Heimbürger O, Wang T, Lonnqvist F, Stenvinkel P. Peritoneal clearence of leptin in CAPD patients: impact of local insulin administration. Nephrol Dial Transplant 1999;14:723-727.
28. Stenvinkel P, Lindholm B, Lonnqvist F, Katzaarski K, Heimbürger O. Increases in serum leptin levels during peritoneal dialysis are associated with inflammation and a decrease in lean body mass. J Am Soc Nephrol 2000;11:1303-1309.

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