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Aminoglikozid Kullanımına Bağlı Gelişen ABY

Aminoglycoside Induced Acute Renal Failure

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 2006
Author NameUniversity of AuthorFaculty of Author
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Abstract (Original Language): 
Aminoglikozidler (AG) hayatı tehdit eden gram-negatif infeksiyonlardaki güçlü etkinliklerinden dolayı oldukça yaygın bir şekilde kullanılmaktadır. Ancak nefrotoksisite ve otovestibüler toksisite sık görülen bir yan etki olmakta ve aminoglikozid kullanımını belirgin bir şekilde sınırlandırmaktadır. Tedavi gören vakaların yaklaşık %10-15'inde akut tü-büler nekroza bağlı akut böbrek yetersizliği geliş¬mektedir (1).
FULL TEXT (PDF): 
PDF icon arastrmx_172977_15_pp_48-50.pdf
  • 1
48-50
  • Turkish

REFERENCES

References: 

1. Humes HD. Aminoglycoside nephrotoxicity. Kidney Int 1988;33:900.
2. Moestrup SK, Cui S, Vorum H, et al. Evidence that epithelial glycoprotein 330/megalin mediates uptake of polybasic drugs. J Clin Invest 1995;96:1404.
3. Laurent G, Kishore BK, Tulkens PM. Aminoglycoside-indu-ced renal phospholipidosis and nephrotoxicity. Biochem Pharmacol 1990;40:2383-2392.
4. Laurent G, Maldague P, Carlier MB, Tulkens P. Increased re¬nal DNA synthesis in vivo after administration of low doses of gentamicin in rats. Antimicrob Agents Chemother 1983;24: 586-593.
5. Houghton DC, English J, Bennett WM. Chronic tubulointerstiti-al nephritis and renal insufficiency associated with long-term "subtherapeutic" gentamicin. J Lab Clin Med 1988;112:694.
6. Smith CR, Lipsky JJ, Oetty BG, et al. Double-blind compari¬son of the nephrotoxicity and auditory toxicity of gentamicin and tobramycin. N Engl J Med 1980;302:1106.
7. Barza M, Ioannidis JP, Cappelleri JC, Lau J. Single or multip¬le daily doses of aminoglycosides: A meta-analysis. BMJ
1996;312:338.

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